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CLVS

Clovis

$3.99

-0.02 (-0.50%)

16:15
09/29/19
09/29
16:15
09/29/19
16:15

Clovis announces updated data from Phase 2 TRITON2 trial

Clovis Oncology announced updated data from the Phase 2 TRITON2 trial at the European Society for Medical Oncology Congress 2019, reinforcing the potential of Rubraca for the treatment of patients with metastatic castration-resistant prostate cancer with a BRCA1/2 mutation. The data show a 43.9% confirmed objective response rate by investigator assessment in 57 RECIST/PCWG3 response-evaluable patients with a BRCA1/2 mutation. When assessed by independent radiological review, the response rate was similar. In addition, a 52.0% confirmed prostate-specific antigen response rate was observed in 98 response-evaluable patients with a BRCA1/2 mutation. Confirmed radiographic responses were durable, with 60% lasting 24 weeks or longer. The TRITON2 data will be used to support the filing of Clovis Oncology's planned supplemental NDA to the Food and Drug Administration for Rubraca in BRCA1/2-mutant advanced prostate cancer. Confirmed investigator-assessed RECIST and PSA responses were also observed in patients with alterations in other DDR genes, including ATM, CDK12, CHEK2, PALB2, BRIP1, FANCA, and RAD51B. The median duration of follow-up for patients in TRITON2 was 13.1 months with the safety profile consistent with prior reports. Clovis Oncology is further evaluating the potential of Rubraca to treat advanced prostate cancer in the TRITON3 clinical trial - a multicenter, randomized, open-label Phase 3 study of Rubraca versus physician's choice of therapy - for patients with mCRPC. TRITON3 is currently enrolling patients with BRCA1/2-mutant and ATM-mutant tumors with a primary objective of assessing radiographic progression-free survival in these patients.

CLVS Clovis
$3.99

-0.02 (-0.50%)

08/02/19
GUGG
08/02/19
DOWNGRADE
GUGG
Neutral
Clovis downgraded to Neutral on Rubraca sales growth struglles at Guggenheim
As previously reported, Guggenheim analyst Michael Schmidt downgraded Clovis to Neutral from Buy as the company continues to struggle to meaningfully grow Rubraca sales in its approved indication, which is a situation he doesn't believe will improve in the near-term as competitor drugs gain more traction. While Clovis is working toward expanding Rubraca use to other types of cancer, most of these trials won't complete until 2020 and 2021, said Schmidt, who removed his prior $35 price target on the stock.
08/13/19
BOFA
08/13/19
DOWNGRADE
Target $7
BOFA
Neutral
Clovis downgraded to Neutral from Buy at BofA/Merrill
BofA/Merrill Tazeen Ahmad downgraded Clovis (CLVS) to Neutral and lowered his price target to $7 from $13 after last week's release of positive topline results for its PARP inhibitor Lynparza to treat prostate cancer by the company's competitor AstraZeneca (AZN). The analyst notes that the Lynparza update alters his expectations in the prostate cancer market to assume a two-player landscape from day one, reducing his expectations for Clovis's Rubraca peak sales to $250M from $406M with peak U.S. BRCA penetration of 15%.
09/24/19
LEER
09/24/19
DOWNGRADE
LEER
Market Perform
Clovis downgraded to Market Perform from Outperform at SVB Leerink
09/24/19
09/24/19
DOWNGRADE
Target $10

Market Perform
Clovis downgraded to Market Perform following in-licensing deal at SVB Leerink
As previously reported, SVB Leerink analyst Andrew Berens downgraded Clovis to Market Perform from Outperform on the heels of the company's announcement of an in-licensing deal, which he finds ill-timed given investor concerns about its use of cash and solvency amidst an increasing mountain of convertible debt. While the deal to in-license a radiotherapy for about $12M up front does not seem exorbitant and could eventually add fundamental value, it burdens Clovis with development expenses and milestones at a time when equity investors are increasingly concerned that the company is not aligned with their best interests, he adds. Berens also lowered his price target on the shares to $10 from $22.

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AMZN

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AKS

AK Steel

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0.055 (2.30%)

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Zurich Insurance

$0.00

(0.00%)

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STT

State Street

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SUN

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TLF

Tandy Leather

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AAPL

Apple

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JPM

JPMorgan

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, FB

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MA

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V

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BKNG

Booking Holdings

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GLD

SPDR Gold Shares

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-0.13 (-0.09%)

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TECK

Teck Resources

$16.48

0.11 (0.67%)

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OSK

Oshkosh

$77.22

0.46 (0.60%)

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OVLY

Oak Valley Bancorp

$16.40

-0.16 (-0.97%)

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FTNW

FTE Networks

$0.79

-0.0185 (-2.29%)

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TNXP

Tonix Pharmaceuticals

$0.45

0.0048 (1.07%)

17:12
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RLMD

Relmada Therapeutics

$20.18

1.07 (5.60%)

17:10
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16:55
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General news
Breaking General news story  »

Dallas Federal Reserve…

NWSA

News Corp.

$13.48

-0.19 (-1.39%)

, NWS

News Corp

$13.79

-0.11 (-0.79%)

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NWSA

News Corp.

$13.48

-0.19 (-1.39%)

NWS

News Corp

$13.79

-0.11 (-0.79%)

FB

Facebook

$185.96

-4.435 (-2.33%)

NYT

New York Times

$29.76

0.21 (0.71%)

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WAIR

Wesco Aircraft

$11.01

0.01 (0.09%)

16:46
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Conference/Events
Wesco Aircraft to host special shareholder meeting »

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FOMX

Foamix

$3.15

-0.09 (-2.78%)

16:41
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Hot Stocks
Breaking Hot Stocks news story on Foamix »

Foamix up 7.5% at $3.35…

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