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IDRA

Idera Pharmaceuticals

$2.64

0.01 (0.38%)

07:38
09/30/19
09/30
07:38
09/30/19
07:38

Idera Pharmaceuticals announces initiation of ILLUMINATE-206 trial

Idera Pharmaceuticals announced the initiation of a phase 2 trial, ILLUMINATE-206 which will evaluate tilsotolimod, a toll-like receptor 9 agonist, in combination with nivolumab, a programmed death receptor-1 blocking antibody, and ipilimumab, a human cytotoxic T-lymphocyte antigen 4 blocking antibody for the treatment of solid tumors. The primary objective of this phase 2, open-label, global, study is to demonstrate efficacy. Secondary and exploratory objectives include safety, tolerability, immunogenicity and translational data evaluations. The initial cohort of the trial will be patients with immunotherapy-naive Microsatellite Stable Colorectal Cancer. The second planned cohort of ILLUMINATE-206 will focus on treating patients with anti-PD-1 refractory Squamous Cell Carcinoma of the Head and Neck, which will initiate in the fourth quarter of this year. The basis for this trial is supported by data generated from the ILLUMINATE-101 trial, which studied intratumoral tilsotolimod monotherapy in 45 evaluable patients with a variety of solid tumor types in which 33% achieved stable disease. Translational research in ILLUMINATE-101, demonstrated that tilsotolimod increased dendritic cell activation and upregulated MHC class II and IFN-alpha signaling which suggests improved antigen presentation. These findings are consistent with those observed in the ILLUMINATE-204 trial in anti-PD-1 refractory metastatic melanoma patients. Therefore, the mechanism of action for tilsotolimod may be tumor-type agnostic and potentially beneficial in combination with checkpoint modulation in a variety of tumor types.

IDRA Idera Pharmaceuticals
$2.64

0.01 (0.38%)

12/17/18
WEDB
12/17/18
NO CHANGE
Target $16
WEDB
Outperform
Wedbush 'positive' on Idera's Phase 2 study data
Wedbush analyst Robert Driscoll reiterated an Outperform rating and $16 price target on Idera Pharmaceuticals after the company updated results from the ongoing Phase 2 study of tilsotolimod plus ipilumumab in patients with PD-1 refractory melanoma. In a research note to investors, Driscoll says he remains "positive" on the study data, which he believe supports the ongoing Phase 3, and adds that ORR has tracked slightly lower than the previous data cut, but he believes 29.4% remains clinically meaningful with the potential to improve as tumor reductions continue to evolve over time.
03/07/19
WEDB
03/07/19
NO CHANGE
Target $7
WEDB
Outperform
Idera Pharmaceuticals price target lowered to $7 from $16 at Wedbush
Wedbush analyst Robert Driscoll lowered his price target for Idera Pharmaceuticals to $7 from $16 after he tweaked his market assumptions for tilosotolimod in refractory melanoma to be more conservative as the landscape evolves. The analyst continues to see tilsotolimod as a differentiated I-O asset that is being developed in a rational I-O clinical strategy, and reiterates an Outperform rating on the shares.
03/08/19
HCWC
03/08/19
NO CHANGE
Target $14
HCWC
Buy
Idera Pharmaceuticals price target lowered to $14 from $18 at H.C. Wainwright
H.C. Wainwright analyst Swayampakula Ramakanth lowered his price target for Idera Pharmaceuticals to $14 following this week's Q4 results and corporate update. The new target reflects additional dilution from the stock purchase agreement. The analyst keeps a Buy rating on the shares.

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