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LH

LabCorp

$165.41

-1.59 (-0.95%)

08:49
09/30/19
09/30
08:49
09/30/19
08:49

LabCorp publishes study of cfDNA screenings in multifetal pregnancies

LabCorp recently published results of the largest study to date of cell-free DNA, or cfDNA, screenings in multifetal pregnancies. The study, published in PLOS ONE, determined that non-invasive cfDNA screening using the MaterniT21 PLUS test offered by LabCorp's Integrated Genetics provided results that compare favorably to those for singleton pregnancies. A woman's age-related risk for aneuploidy in most multifetal pregnancies is elevated compared to that of a woman of the same maternal age carrying a singleton pregnancy, and reliable cfDNA screening can provide valuable information to help guide care decisions. The study, conducted by leading LabCorp geneticists, assesses the reliability and accuracy of cfDNA screening in multifetal pregnancies by examining four areas: current experiences with biochemical screening in twins, the observed performance of cfDNA screening in multiples, the cfDNA screening positivity rate and total non-reportable rate in all multifetal gestations. Of the 750,000 samples received by LabCorp for MaterniT21 PLUS screening during the study period of October 2011 to December 2017, 4% were from multifetal pregnancies. Previous clinical validation studies in singleton pregnancies have established the high sensitivity and specificity of cfDNA screening, as well as increased detection rates, lower false-positive rates and higher positive-predictive values over that of conventional prenatal screening methods. This study found that cfDNA screening in patients with multifetal gestations meets or exceeds performance from original clinical validation studies on singleton pregnancies. The collective positivity rate of resulted samples in the study was 2.19%. Positive rates for trisomy 21, 18 and 13 were 1.5%, 0.48% and 0.21% respectively. The average fetal fraction was 12.33% in twins and 13.20% in triplets. The quantity-not-sufficient, or QNS, non-reportable rate was higher in multifetal vs singleton pregnancies, which is related to more stringent fetal fraction requirements for multiple gestations as compared to singletons. The study is the largest published sample of the use of non-invasive prenatal cfDNA screening on twins, triplets and higher-order multiples. The data on 709 triplets is particularly significant because there are currently no other non-invasive prenatal laboratory screening options available in these pregnancies. In addition, current clinical practice guidelines do not recommend the use of cfDNA in aneuploidy screening in women with multiple gestations. This study increases the body of evidence supporting cfDNA as an alternative to traditional prenatal screening methodologies in multifetal pregnancies.

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LH LabCorp
$165.41

-1.59 (-0.95%)

07/16/19
07/16/19
UPGRADE

Fly Intel: Top five analyst upgrades
Catch up on today's top five analyst upgrades with this list compiled by The Fly: 1. LabCorp (LH) upgraded to Neutral from Underperform at BofA/Merrill with analyst Derik De Bruin saying he has become increasingly more constructive on industry trends since January. 2. Timken (TKR) upgraded to Buy from Neutral at Goldman Sachs with analyst Joseph Ritchie saying he shuffled his ratings in the Americas Multi-Industry ahead of the Q2 earnings season. 3. Freeport McMoRan (FCX) upgraded to Equal Weight from Underweight at Barclays while Wheaton Precious Metals (WPM) was upgraded to Overweight from Equal Weight. 4. OneMain Holdings (OMF) upgraded to Overweight from Neutral at JPMorgan with analyst Richard Shane saying with the shares trading at almost a 30% discount to the peer median, the stock can deliver a mid- to high-teens return through 2020. 5. Nokia (NOK) upgraded to Buy from Hold at Danske Bank. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.
07/25/19
PIPR
07/25/19
NO CHANGE
Target $183
PIPR
Overweight
Piper more confident after LabCorp results, boosts target to $183
Piper Jaffray analyst William Quirk raised his price target for LabCorp to $183 from $177 following the company's fiscal Q1 results and maintains an Overweight rating on the shares. The analyst says Covance continues to outperform and that "incremental visibility" around diagnostics leaves him confident in the company's ability to deliver in 2019.
09/03/19
KEYB
09/03/19
NO CHANGE
KEYB
Quest Diagnostics, LabCorp could be impacted by Hurricane Dorian, says KeyBanc
KeyBanc analyst Donald Hooker notes that both Quest Diagnostics (DGX) and LabCorp (LH) operate facilities in Florida and the Southeast that could be negatively impacted by Hurricane Dorian. In prior years, bad hurricane seasons have negatively impacted year over year patient volumes by anywhere from 30-160 bps for both companies, with a more pronounced bottom-line impact given the economies of scale in lab testing, he adds. However, the analyst suspects that the financial impact may be mitigated this year given the significant changes at both Quest and LabCorp. As an initial take, Hooker would ballpark a bad hurricane season for Quest could represent about $20M of revenue headwind and 6c of EPS headwind, while for LabCorp, the headwind could be about $17M and 6c, respectively.
09/16/19
09/16/19
NO CHANGE

LabCorp management to meet with SunTrust
Meeting to be held in Boston on September 16 hosted by SunTrust.

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MDT

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BR

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MCD

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SYF

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KEY

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RCL

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MRK

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AMZN

Amazon.com

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-17.22 (-0.98%)

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MSFT

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AAPL

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CI

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CNC

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CVS

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HUM

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UNH

UnitedHealth

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13.68 (5.35%)

WCG

WellCare

$312.01

10.155 (3.36%)

HNT

Health Net

$0.00

(0.00%)

MOH

Molina Healthcare

$129.60

7.3 (5.97%)

ANTM

Anthem

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HCA

HCA Healthcare

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3.51 (2.61%)

CYH

Community Health

$3.12

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LPNT

LifePoint

$0.00

(0.00%)

UHS

Universal Health

$144.30

3.13 (2.22%)

THC

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$30.55

1.08 (3.66%)

GM

General Motors

$36.87

0.07 (0.19%)

FCAU

Fiat Chrysler

$16.02

0.04 (0.25%)

TM

Toyota

$144.29

1.16 (0.81%)

F

Ford

$8.96

0.16 (1.82%)

HMC

Honda

$28.99

0.155 (0.54%)

VWAGY

Volkswagen

$0.00

(0.00%)

BMWYY

BMW

$0.00

(0.00%)

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MDCO

The Medicines Co.

$51.92

1.03 (2.02%)

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  • 16

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CVET

Covetrus

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CMCSK

Comcast

$0.00

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  • 09

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CWK

Cushman & Wakefield

$19.10

0.1 (0.53%)

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  • 12

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LMT

Lockheed Martin

$393.52

3.305 (0.85%)

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ESCA

Escalade

$10.90

-0.09 (-0.82%)

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CZR

Caesars

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, ERI

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CZR

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  • 15

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EGRX

Eagle Pharmaceuticals

$57.24

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FN

Fabrinet

$60.82

0.84 (1.40%)

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Fabrinet President Gill sells 12.9K shares of common stock »

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  • 12

    Dec

TEUM

Pareteum

$0.38

-0.0209 (-5.21%)

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HEXO

Hexo

$1.78

-0.1 (-5.32%)

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AMGN

Amgen

$220.84

2.29 (1.05%)

, CELG

Celgene

$110.02

-0.01 (-0.01%)

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AMGN

Amgen

$220.84

2.29 (1.05%)

CELG

Celgene

$110.02

-0.01 (-0.01%)

BMY

Bristol-Myers

$58.61

0.11 (0.19%)

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RAVE

Rave Restaurant

$1.44

-0.79 (-35.43%)

16:47
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BBRC Asset Management reports 6.6% passive stake in Rave Restaurant »

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CHAP

Chaparral Energy

$0.89

-0.0521 (-5.52%)

16:46
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Chaparral Energy receives continued listing standard notice from NYSE »

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16:45
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General news
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CI

Cigna

$196.08

6.41 (3.38%)

, CNC

Centene

$57.57

2.91 (5.32%)

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On The Fly
Fly Intel: Wall Street's top stories for Friday »

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CI

Cigna

$196.08

6.41 (3.38%)

CNC

Centene

$57.57

2.91 (5.32%)

CVS

CVS Health

$74.27

1.34 (1.84%)

HUM

Humana

$335.43

17.48 (5.50%)

UNH

UnitedHealth

$269.44

13.68 (5.35%)

WCG

WellCare

$312.01

10.155 (3.36%)

HNT

Health Net

$0.00

(0.00%)

MOH

Molina Healthcare

$129.60

7.3 (5.97%)

ANTM

Anthem

$298.18

16.14 (5.72%)

HCA

HCA Healthcare

$137.98

3.51 (2.61%)

CYH

Community Health

$3.12

0.25 (8.71%)

LPNT

LifePoint

$0.00

(0.00%)

UHS

Universal Health

$144.30

3.13 (2.22%)

NVDA

Nvidia

$204.12

-5.76 (-2.74%)

AMZN

Amazon.com

$1,739.33

-15.38 (-0.88%)

MSFT

Microsoft

$149.95

1.89 (1.28%)

UAA

Under Armour

$17.78

0.65 (3.79%)

UA

Under Armour

$15.97

0.41 (2.64%)

AMRN

Amarin

$23.99

2.5 (11.63%)

JNJ

Johnson & Johnson

$134.97

3.99 (3.05%)

GOOG

Alphabet

$1,334.01

21.82 (1.66%)

GOOGL

Alphabet Class A

$1,333.33

23.54 (1.80%)

ORCL

Oracle

$56.43

0.33 (0.59%)

RH

RH

$188.73

13.535 (7.73%)

QGEN

Qiagen

$40.56

3.255 (8.73%)

FTCH

Farfetch

$9.66

2.17 (28.97%)

THC

Tenet

$30.55

1.08 (3.66%)

TORC

resTORbio

$1.10

-6.83 (-86.13%)

ACB

Aurora Cannabis

$2.72

-0.57 (-17.33%)

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NYT

New York Times

$31.60

0.44 (1.41%)

16:41
11/15/19
11/15
16:41
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16:41
Hot Stocks
New York Times CEO sells 66,000 class A common shares »

In a regulatory filing,…

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  • 09

    Dec

WEX

Wex

$200.52

4.61 (2.35%)

16:41
11/15/19
11/15
16:41
11/15/19
16:41
Hot Stocks
Wex director Morris sells 3K shares of common stock »

In a regulatory filing,…

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