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ARPO

Aerpio Pharmaceuticals

$0.61

-0.0155 (-2.48%)

14:33
10/10/19
10/10
14:33
10/10/19
14:33

Aerpio announces trial data for primary open angle glaucoma treatment

Aerpio Pharmaceuticals announced interim results from its Phase 1b clinical trial of a topical ocular formulation of AKB-9778 in development as a potential treatment for primary open angle glaucoma,POAG. "We are encouraged by the early safety findings and potential efficacy signal of this ongoing Phase 1b trial," said Kevin Peters, M.D., Chief Scientific Officer of Aerpio Pharmaceuticals. "The conventional outflow tract is responsible for the majority of fluid drainage from the front of the eye, which is critical for maintaining normal IOP and is often the site of pathology implicated in the increased IOP in patients suffering from POAG. Recent mouse and human genetic data establish a key role for the Tie2 pathway in the development and maintenance of Schlemm's canal, a key component of the conventional outflow tract. AKB-9778, a potent small molecule Tie2 activator, has shown IOP lowering effects after subcutaneous administration in two sequential Phase 2 studies in patients with diabetic retinopathy and normal IOP. We now look forward further to evaluating AKB-9778's safety and activity on IOP in patients with ocular hypertension and POAG."

ARPO Aerpio Pharmaceuticals
$0.61

-0.0155 (-2.48%)

03/18/19
NATL
03/18/19
DOWNGRADE
NATL
Neutral
Aerpio Pharmaceuticals downgraded to Neutral from Buy at National Securities
03/18/19
GUGG
03/18/19
DOWNGRADE
GUGG
Neutral
Aerpio Pharmaceuticals downgraded to Neutral from Buy at Guggenheim
03/19/19
HCWC
03/19/19
DOWNGRADE
HCWC
Neutral
Aerpio Pharmaceuticals downgraded to Neutral from Buy at H.C. Wainwright
H.C. Wainwright analyst Raghuram Selvaraju downgraded Aerpio Pharmaceuticals to Neutral from Buy without a price target after the company's Time-2b trial failed to meet its primary endpoint in diabetic retinopathy. The analyst steps to the sidelines pending management's clarification on the direction of the program.
03/19/19
CANT
03/19/19
NO CHANGE
Target $3
CANT
Overweight
Aerpio selloff overly discounts ongoing glaucoma program, says Cantor Fitzgerald
Cantor Fitzgerald analyst Eliana Merle lowered her price target for Aerpio Pharmaceuticals to $3 from $8 after the company announced the Time-2B Phase 2b study missed its primary endpoint in diabetic retinopathy. The shares are currently trading close to cash, which overly discounts the potential for partner milestones and the ongoing glaucoma program, Merle tells investors in a research note. She sees a favorable risk/reward into potential updates on Aerpio's other programs and keeps an Overweight rating on the name.

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