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GERN

Geron

$1.44 /

+0.03 (+2.14%)

17:32
10/10/19
10/10
17:32
10/10/19
17:32

Geron announces first patient has been dosed in IMerge Phase 3 clinical trial

Geron Corporation announced that the first patient has been dosed in the IMerge Phase 3 clinical trial to evaluate imetelstat, a first-in-class telomerase inhibitor, in lower risk myelodysplastic syndromes, or MDS. IMerge is a two-part Phase 2/3 clinical trial of imetelstat in transfusion dependent patients with lower risk MDS who are relapsed after or refractory to erythropoiesis-stimulating agents, or ESAs. The Phase 3 is planned to enroll approximately 170 patients in a randomized, double-blind, placebo-controlled clinical trial to test the hypothesis that imetelstat improves the rate of red blood cell transfusion independence, or TI. The primary endpoint is 8-week TI rate, which is defined as the proportion of patients achieving transfusion independence during any consecutive eight weeks since entry into the trial. Key secondary endpoints include the rate of transfusion independence lasting at least 24 weeks, or 24-week TI rate, durability of transfusion independence and the amount and relative change in transfusions. Based upon current planning assumptions, Geron expects top-line results for the IMerge Phase 3 clinical trial to be available by mid-year 2022.

GERN Geron
$1.44 /

+0.03 (+2.14%)

09/03/19 H.C. Wainwright
Geron initiated with a Buy at H.C. Wainwright
08/15/19 Cantor Fitzgerald
Geron initiated with an Overweight at Cantor Fitzgerald
06/28/19 B. Riley FBR
Geron price target raised to $4.50 from $3.25 at B. Riley FBR
04/09/19
Fly Intel: Top five analyst upgrades

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Dunkin' Brands

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Orsted A/S

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Starbucks price target lowered to $70 from $74 at Piper Sandler » 06:17
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SBUX

Starbucks

$67.81 /

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Recommendations
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MCD

McDonald's

$177.02 /

+16.62 (+10.36%)

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GWW

Grainger

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Centrica downgraded to Neutral from Buy at UBS » 06:15
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Centrica

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General news
Russia is ready to discuss "very substantial" crude output cuts » 06:15
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Repsol upgraded to Outperform from Market Perform at Bernstein » 06:14
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Repsol

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