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KOD

Kodiak Sciences

$18.24

1.34 (7.93%)

18:34
10/13/19
10/13
18:34
10/13/19
18:34

Kodiak Sciences announces safety, efficacy from Phase 1b study of KSI-301

Kodiak Sciences announced promising safety, efficacy and durability data from its ongoing Phase 1b study of its investigational therapy KSI-301 in patients with treatment-naive wet age-related macular degeneration, diabetic macular edema and retinal vein occlusion. "We continue to observe encouraging safety and efficacy data in the Phase 1b study of KSI-301, and the emerging durability data are remarkable," said Jason Ehrlich, Chief Medical Officer of Kodiak Sciences. "In wet AMD, a next-generation intravitreal biologic would bring nearly all patients to a three month or longer dose interval. Our early data suggest this is achievable using KSI-301, with 87% of wet AMD patients extending beyond three months after the last loading dose without receiving retreatment. In DME, a pan-retinal disease that typically has a high initial treatment burden, we observed that 82% of patients were extended beyond three months without receiving retreatment following only three initial loading doses. Further, we are seeing promising early signs of improvement in diabetic retinopathy, with 40% of patients improving in diabetic retinopathy severity level within the first twelve weeks of treatment and no patients worsening. In RVO, a disease which typically requires monthly anti-VEGF therapy to achieve the best results, we observed that over half the patients were extended beyond three months after only three loading doses without receiving retreatment and over a quarter of patients received their first retreatment at two months. Interestingly, we also see potential signs of disease modification in RVO as evidenced by a sequentially increased time to retreatment in patients who have received more than one retreatment to date." Victor Perlroth, Chief Executive Officer of Kodiak Sciences, added that, "These new results reinforce our belief in the potential for KSI-301 to reduce treatment burden and improve vision outcomes for patients. To that end, we are designing pivotal studies to demonstrate meaningful differentiation of KSI-301 in each of the retinal vascular diseases. We have begun dosing patients in our DAZZLE pivotal study of KSI-301 in wet AMD, where KSI-301 will be given on an every three-, four- or five-month dosing interval. We look forward to discussing our accelerating plans for the clinical development of KSI-301 at our R&D Day on Monday, October 14."

KOD Kodiak Sciences
$18.24

1.34 (7.93%)

10/29/18
LEHM
10/29/18
INITIATION
Target $20
LEHM
Overweight
Kodiak Sciences initiated with an Overweight at Barclays
Barclays analyst Gena Wang started Kodiak Sciences with an Overweight rating and $20 price target.
10/29/18
10/29/18
INITIATION

On The Fly: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. Apple (AAPL) initiated with a Buy at Jefferies. 2. Ralph Lauren (RL) initiated with a Buy at Deutsche Bank. 3. Guardant Health (GH) initiated with an Outperform at Cowen and William Blair, an Overweight at JPMorgan, and a Neutral at BofA/Merrill. 4. Kodiak Sciences (KOD) initiated with a Buy at BofA/Merrill, as well as an Overweight at Barclays and Morgan Stanley. 5. Proteostasis (PTI) initiated with an Overweight at Piper Jaffray. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.
02/20/19
CHDN
02/20/19
INITIATION
Target $22.5
CHDN
Buy
Kodiak Sciences initiated with a Buy at Chardan
Chardan initiated Kodiak Sciences with a Buy and $22.50 price target.
02/20/19
02/20/19
INITIATION

Fly Intel: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. Kodiak Sciences (KOD) initiated with a Buy at Chardan. 2. Veeva (VEEV) initiated with an Equal Weight at Barclays. 3. Agios Pharmaceuticals (AGIO) assumed with a Perform at Oppenheimer. 4. OrthoPediatrics (KIDS) initiated with an Outperform at JMP Securities. 5. Homology Medicines (FIXX) initiated with a Buy at H.C. Wainwright. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.

TODAY'S FREE FLY STORIES

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WSM

Williams-Sonoma

$70.48

-0.88 (-1.23%)

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W

Wayfair

$84.57

1.28 (1.54%)

21:31
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VFC

VF Corp.

$84.69

-1.7 (-1.97%)

21:28
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VF Corp. initiated at Barclays »

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URBN

Urban Outfitters

$30.85

0.295 (0.97%)

21:25
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Urban Outfitters initiated at Barclays »

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  • 19

    Nov

UAA

Under Armour

$17.29

-0.295 (-1.68%)

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Under Armour initiated at Barclays »

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ULTA

Ulta Beauty

$244.06

2.19 (0.91%)

21:19
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Initiation
Ulta Beauty initiated at Barclays »

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  • 05

    Dec

TJX

TJX

$58.40

-0.14 (-0.24%)

21:15
11/12/19
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21:15
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21:15
Initiation
TJX initiated at Barclays »

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  • 19

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TPR

Tapestry

$26.38

-0.295 (-1.11%)

21:12
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11/12
21:12
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21:12
Initiation
Tapestry initiated at Barclays »

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  • 20

    Nov

AFL

Aflac

$53.97

-0.04 (-0.07%)

21:02
11/12/19
11/12
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21:02
Hot Stocks
Aflac names Frederick Crawford new COO »

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ROST

Ross Stores

$110.97

-1.16 (-1.03%)

21:00
11/12/19
11/12
21:00
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21:00
Initiation
Ross Stores initiated at Barclays »

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  • 21

    Nov

RL

Ralph Lauren

$111.44

-2.58 (-2.26%)

20:57
11/12/19
11/12
20:57
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Initiation
Ralph Lauren initiated at Barclays »

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RH

RH

$174.48

-0.18 (-0.10%)

20:56
11/12/19
11/12
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20:56
Initiation
RH initiated at Barclays »

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PVH

PVH Corp.

$96.91

0.14 (0.14%)

20:53
11/12/19
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Initiation
PVH Corp. initiated at Barclays »

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  • 26

    Nov

JWN

Nordstrom

$36.90

-0.52 (-1.39%)

20:51
11/12/19
11/12
20:51
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20:51
Initiation
Nordstrom initiated at Barclays »

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03/06/13
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  • 20

    Nov

NKE

Nike

$89.51

-0.52 (-0.58%)

20:46
11/12/19
11/12
20:46
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20:46
Initiation
Nike initiated at Barclays »

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EYE

National Vision

$27.03

0.24 (0.90%)

20:43
11/12/19
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National Vision initiated at Barclays »

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LB

L Brands

$17.53

0.02 (0.11%)

20:40
11/12/19
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Initiation
L Brands initiated at Barclays »

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  • 21

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BABA

Alibaba

$186.97

0.26 (0.14%)

20:25
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Periodicals
Alibaba gets approval to sell shares in Hong Kong, SCMP reports »

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  • 19

    Nov

ENR

Energizer

$42.01

-1.1 (-2.55%)

, SPB

Spectrum Brands

$51.19

-0.76 (-1.46%)

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Earnings
Notable companies reporting before tomorrow's open »

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ENR

Energizer

$42.01

-1.1 (-2.55%)

SPB

Spectrum Brands

$51.19

-0.76 (-1.46%)

SSYS

Stratasys

$20.74

0.04 (0.19%)

FVRR

Fiverr

$21.56

-0.47 (-2.13%)

MTOR

Meritor

$23.44

-0.25 (-1.06%)

03/08/13
Wedge Partners
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  • 13

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DDOG

Datadog

$34.40

0.89 (2.66%)

20:02
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Hot Stocks
Datadog establishes Japanese subsidiary »

Datadog announced that it…

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  • 12

    Nov

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    Nov

NKE

Nike

$89.51

-0.52 (-0.58%)

, AMZN

Amazon.com

$1,778.33

6.63 (0.37%)

19:40
11/12/19
11/12
19:40
11/12/19
19:40
Periodicals
Nike says to end retail pilot project w/ Amazon.com but continue AWS partnership 

Report from Bloomberg.

NKE

Nike

$89.51

-0.52 (-0.58%)

AMZN

Amazon.com

$1,778.33

6.63 (0.37%)

03/08/13
Wedge Partners
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03/06/13
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  • 13

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    Nov

HPE

HP Enterprise

$17.34

-0.11 (-0.63%)

, FJTSY

Fujitsu

$0.00

(0.00%)

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Hot Stocks
HP Enterprise's Cray to partner with Fujitsu on 'supercomputer' technology »

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HPE

HP Enterprise

$17.34

-0.11 (-0.63%)

FJTSY

Fujitsu

$0.00

(0.00%)

03/08/13
Wedge Partners
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  • 25

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