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PRNB

Principia Biopharma

$29.18

0.16 (0.55%)

07:30
10/15/19
10/15
07:30
10/15/19
07:30

Principia Biopharma announces preliminary data of Phase 1/2 trial of PRN1008

Principia Biopharma announced preliminary data from an ongoing Phase 1/2 trial of its investigational treatment, PRN1008, in a highly treatment-resistant and refractory patient population with immune thrombocytopenia. Further updated data from the trial will be presented at an oral scientific session at the 61st American Society of Hematology Annual Meeting in December. To date, the Phase 1/2 trial of PRN1008 has enrolled 26 adult patients who have had two platelet counts less than 30,000/microL within 15 days prior to treatment. Oral PRN1008 starting doses were 200mg once daily, 400mg once daily, 300mg twice daily, and 400mg twice daily, with intra-patient dose escalation allowed every four weeks, with the trial having a current median treatment duration of 12.7 weeks. Of the 26 patients enrolled to date, 39 percent achieved the trial's primary endpoint of greater than or equal to 2 consecutive platelet counts of greater than or equal to 50,000/microL, separated by at least five days, and increased by greater than or equal to 20,000/microL from baseline without requiring rescue medication. In addition, 46 percent of enrolled patients achieved any 2 platelet counts greater than or equal to 50,000/microL. These results were observed despite the limited duration of therapy and patients at multiple escalating dose levels. In the preliminary data on 15 patients across all doses who had completed at least 12 weeks of therapy, the response rate was greater than 50 percent for both endpoints. To date PRN1008 has been well-tolerated at all doses studied, whether given as a monotherapy or with allowed concomitant ITP therapy, with no reported treatment related bleeding or thrombotic events.

PRNB Principia Biopharma
$29.18

0.16 (0.55%)

07/01/19
HCWC
07/01/19
INITIATION
Target $55
HCWC
Buy
Principia Biopharma initiated with a Buy at H.C. Wainwright
H.C. Wainwright analyst Joseph Pantginis started Principia Biopharma with a Buy rating and $55 price target. The company's PRN1008 could deliver a new therapy in pemphigus vulgaris and also offers a "meaningful" commercial opportunity in immune thrombocytopenia, Pantginis tells investors in a research note.
10/02/19
STFL
10/02/19
NO CHANGE
Target $45
STFL
Buy
Stifel remains buyer of Principia Biopharma into Q4 data readouts
Stifel analyst Derek Archila remains bullish and a buyer of Principia Biopharma (PRNB) shares ahead of the company's two Phase 2 readouts for PRN1008 in immune thrombocytopenia and pemphigus vulgaris. The shares could reach the mid-$50 range if results are positive, Archila tells investors in a research note. He believes the bogey for each study is not that high and keeps a Buy rating on Principia with a $45 price target. The two clinical catalysts, coupled with Phase 2 data expected in the first half of 2020 from the company's partnered program with Sanofi (SNY) in multiple sclerosis, offers "multiple shots for valuation creation" over the next nine months.
10/10/19
STFL
10/10/19
NO CHANGE
Target $51
STFL
Buy
Principia Biopharma price target raised to $51 from $45 at Stifel
Stifel analyst Derek Archila raised his price target on Principia Biopharma shares to $51 from $45 after the company reported PRN1008 has demonstrated a complete response rate ahead of his expectations thus far in the company's its Phase 2 extension study in pemphigus vulgaris. More importantly, PRN1008 replicated its benign safety and tolerability profile at 24 weeks, even at higher dosing, Archila tells investors. The analyst, who said he would be "buying the stock here," maintains a Buy rating and keeps it on Stifel's Select List.
10/10/19
HCWC
10/10/19
NO CHANGE
HCWC
Principia announces 'positive' data from Phase 2 trial, says H.C. Wainwright
H.C. Wainwright analyst Joseph Pantginis reiterated a Buy rating and $55 price target on Principia Biopharma after the company announced positive interim data from the open label Part B of its PRN1008 Phase 2 trial in pemphigus vulgaris, or PV, which included the selection of an optimized dosing. In a note to investors titled 'Consistency Is the Message of the Day for PV Efficacy,' the analyst said the Phase 2 results helped to boost his confidence in the ongoing Pegasus Phase 3 trial of PRN1008 in PV.

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