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PHAS

PhaseBio

$3.94

-0.24 (-5.74%)

08:04
10/15/19
10/15
08:04
10/15/19
08:04

PhaseBio announces first patient dosed in Phase 2b clinical trial of PB2452

PhaseBio Pharmaceuticals announced that the first patient has been dosed in a Phase 2b clinical trial of PB2452, a novel, recombinant, human monoclonal antibody antigen-binding fragment designed to reverse the antiplatelet activity of ticagrelor in major bleeding and urgent surgery situations. The Phase 2b multi-center, randomized, double-blind, placebo-controlled trial is designed to evaluate the safety and efficacy of PB2452 in reversing the antiplatelet effects of ticagrelor as part of a dual antiplatelet regimen including low-dose aspirin. Additionally, the Phase 2b trial marks the beginning of United States Food and Drug Administration- aligned registrational trials to support the submission of a Biologics License Application for potential accelerated approval of PB2452. Approximately 200 older and elderly subjects are expected to be enrolled, resembling the patient population most likely to be treated with ticagrelor and potentially benefit from PB2452, if approved. Subjects will be randomized in a ratio of 3:1 and will receive either PB2452 or placebo, with approximately 150 subjects receiving PB2452. The primary endpoint of the trial is reversal of the antiplatelet effects of ticagrelor with intravenous infusion of PB2452 or placebo, as measured by the VerifyNow PRUTest biomarker. PhaseBio recently completed a Phase 2a trial in which PB2452 achieved immediate and sustained reversal of the antiplatelet effects of ticagrelor in older and elderly subjects on dual antiplatelet therapy of ticagrelor and low-dose aspirin. PB2452 was generally well tolerated, with only minor adverse events reported. These results are consistent with the results observed in healthy younger subjects treated with ticagrelor in the previously published Phase 1 trial. Additionally, the Phase 2a trial investigated a PB2452 regimen for the reversal of supratherapeutic doses of ticagrelor in healthy younger subjects, which demonstrated immediate and sustained reversal of the antiplatelet effects of ticagrelor and was well tolerated, consistent with the earlier cohorts in the Phase 2a trial and the Phase 1 trial.

PHAS PhaseBio
$3.94

-0.24 (-5.74%)

11/13/18
NEED
11/13/18
INITIATION
Target $18
NEED
Buy
PhaseBio initiated with a Buy at Needham
Needham analyst Chad Messer initiated PhaseBio (PHAS) with a Buy rating and a price target of $18, saying it poses an "attractive investment with a near term commercial opportunity from PB2452" - the closes to market threat to AstraZeneca's (AZN) Brilinta to treat orphan cardiopulmonary diseases. The analyst notes that the company is also evaluating PB1046, which is a "weekly injectable form of vasoactive intestinal peptide with a vastly increased half life over the natural form", for potential treatment of rare pulmonary arterial hypertension.
11/13/18
11/13/18
INITIATION

On The Fly: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. Aerie Pharmaceuticals (AERI) initiated with an Outperform at Oppenheimer. 2. SolarWinds (SWI) initiated with a Buy at Nomura Instinet, SunTrust, Citi, and Goldman Sachs, an Outperform at RBC Capital, Baird, Credit Suisse, JMP Securities, and Evercore ISI, an Overweight at JPMorgan, an Equal Weight at Morgan Stanley and Barclays, as well as a Sector Weight at KeyBanc. 3. PhaseBio (PHAS) initiated with a Buy at Needham. 4. LogicBio Therapeutics (LOGC) initiated with an Overweight at Barclays, a Buy at Chardan, and an Outperform at William Blair. 5. Cree (CREE) initiated with an Outperform at BMO Capital. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.
09/09/19
STFL
09/09/19
NO CHANGE
Target $17
STFL
Buy
PhaseBio selloff on prasugrel vs. ticagrelor study 'well overdone,' says Stifel
Stifel analyst Adam Walsh attributes a roughly 20% selloff last Friday in shares of PhaseBio to a head-to-head study of prasugrel vs. ticagrelor in the ISAR-REACT 5 trial that was recently published in the New England Journal of Medicine. The results were "surprising" to cardiologists, but after speaking with several Key Opinion Leading doctors, Walsh said they cautioned against reading too much into the new data and expect the study to have only a marginal impact on ticagrelor utilization. While he "conservatively" trimmed his PB2452 revenue forecast and lowered his PhaseBio price target to $17 from $20, Walsh reiterated a Buy rating on the stock.
10/03/19
HCWC
10/03/19
INITIATION
Target $18
HCWC
Buy
PhaseBio initiated with a Buy at H.C. Wainwright
H.C. Wainwright analyst Andrew Fein started PhaseBio Pharmaceuticals with a Buy rating and $18 price target. The analyst believes a "clear unmet medical need" exists as ticagrelor or antiplatelet reversal agents are currently unavailable, and that the company's PB2452 could afford healthcare providers significant means to effectively address potentially fatal bleeding risk.

TODAY'S FREE FLY STORIES

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General news
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-1.55 (-2.29%)

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DRH

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OOMA

Ooma

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Intuit

$270.01

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AES

AES Corp.

$18.50

-0.115 (-0.62%)

19:08
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Earnings
AES backs FY19 adjusted EPS view $1.30-$1.38, consensus $1.33 »

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  • 04

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WM

Waste Management

$111.23

-1.305 (-1.16%)

, RSG

Republic Services

$86.78

-0.91 (-1.04%)

19:07
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Initiation
Waste Management, Republic Services, Waste Connections, Clean Harbors, Stericycle, Casella Waste, Covanta initiated  »

Jefferies initiates…

WM

Waste Management

$111.23

-1.305 (-1.16%)

RSG

Republic Services

$86.78

-0.91 (-1.04%)

WCN

Waste Connections

$89.54

-0.28 (-0.31%)

CLH

Clean Harbors

$84.70

-0.75 (-0.88%)

SRCL

Stericycle

$62.49

0.76 (1.23%)

CWST

Casella Waste

$43.70

-0.39 (-0.88%)

CVA

Covanta

$14.43

-0.14 (-0.96%)

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AES

AES Corp.

$18.50

-0.115 (-0.62%)

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AES Corp. says PUCO has modified DP&L rates »

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  • 04

    Dec

ICE

IntercontinentalExchange

$93.89

-0.58 (-0.61%)

, BTC

Bitcoin

$0.00

(0.00%)

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ICE announces launch of Bakkt Bitcoin Cash Settled Monthly Futures contract »

Intercontinental Exchange…

ICE

IntercontinentalExchange

$93.89

-0.58 (-0.61%)

BTC

Bitcoin

$0.00

(0.00%)

BITCOIN

Bitcoin

$0.00

(0.00%)

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MAN

ManpowerGroup

$92.05

-0.355 (-0.38%)

18:51
11/21/19
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Initiation
ManpowerGroup initiated at Jefferies »

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RHI

Robert Half

$58.01

-0.38 (-0.65%)

18:48
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Initiation
Robert Half initiated at Jefferies »

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HTZ

Hertz

$15.37

0.265 (1.76%)

18:46
11/21/19
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18:46
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18:46
Initiation
Hertz initiated at Jefferies »

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CAR

Avis Budget

$28.71

0.16 (0.56%)

18:44
11/21/19
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Initiation
Avis Budget initiated at Jefferies »

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AMD

AMD

$39.52

-1.45 (-3.54%)

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AMD CEO: The key for us is product generation »

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  • 09

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CTAS

Cintas

$253.61

-5.78 (-2.23%)

, BFAM

Bright Horizons

$148.62

-3.92 (-2.57%)

18:42
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Initiation
Cintas, Bright Horizons, Aramark, H&R Block, BrightView, Rollins, ServiceMaster initiated at Jefferies »

Jefferies initiates…

CTAS

Cintas

$253.61

-5.78 (-2.23%)

BFAM

Bright Horizons

$148.62

-3.92 (-2.57%)

ARMK

Aramark

$42.42

-1.37 (-3.13%)

HRB

H&R Block

$24.34

-0.15 (-0.61%)

BV

BrightView

$16.79

-2.525 (-13.08%)

ROL

Rollins

$35.77

-0.8 (-2.19%)

SERV

ServiceMaster

$36.16

-0.42 (-1.15%)

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  • 21

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PINE

Alpine Income Properties

$0.00

(0.00%)

18:34
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Syndicate
Alpine Income Properties 7.5M share IPO priced at $19.00 »

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  • 22

    Nov

OTTW

Ottawa Bancorp

$13.39

-0.39 (-2.83%)

18:28
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Hot Stocks
Ottawa Bancorp approves stock buyback of 317,307 shares »

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MSFT

Microsoft

$149.46

-0.14 (-0.09%)

18:27
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Periodicals
Microsoft says granted U.S. license to do business with Huawei, Bloomberg says »

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  • 02

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  • 09

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SITC

Site Centers

$14.28

-0.275 (-1.89%)

18:24
11/21/19
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Site Centers rating change at Stifel »

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UAL

United Airlines

$90.96

-0.72 (-0.79%)

, BA

Boeing

$366.47

-4.275 (-1.15%)

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United Airlines CEO: We don't think we are near a recession »

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UAL

United Airlines

$90.96

-0.72 (-0.79%)

BA

Boeing

$366.47

-4.275 (-1.15%)

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  • 03

    Dec

FAST

Fastenal

$35.15

-0.1 (-0.28%)

, GWW

Grainger

$312.66

0.305 (0.10%)

18:20
11/21/19
11/21
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18:20
Initiation
Fastenal, Grainger, HD Supply, MSC Industrial, Wesco initiated at Jefferies »

Jefferies initiates…

FAST

Fastenal

$35.15

-0.1 (-0.28%)

GWW

Grainger

$312.66

0.305 (0.10%)

HDS

HD Supply

$39.10

-0.21 (-0.53%)

MSM

MSC Industrial

$73.66

-0.125 (-0.17%)

WCC

Wesco

$53.09

-0.02 (-0.04%)

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  • 10

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SPGI

S&P Global

$264.34

-3.6 (-1.34%)

, INFO

IHS Markit

$71.62

-0.38 (-0.53%)

18:06
11/21/19
11/21
18:06
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18:06
Initiation
S&P Global, IHS Markit, Verisk Analytics, Gartner, FactSet, Equifax, TransUnion, CoStar Group initiated at Jefferies »

Jefferies initiates…

SPGI

S&P Global

$264.34

-3.6 (-1.34%)

INFO

IHS Markit

$71.62

-0.38 (-0.53%)

VRSK

Verisk Analytics

$144.45

0.12 (0.08%)

IT

Gartner

$158.00

0.06 (0.04%)

FDS

FactSet

$258.20

-3.65 (-1.39%)

EFX

Equifax

$137.97

-1.15 (-0.83%)

TRU

TransUnion

$84.90

-1.34 (-1.55%)

CSGP

CoStar Group

$587.66

-7.45 (-1.25%)

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  • 02

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  • 19

    Dec

  • 07

    Jan

GPS

Gap

$16.22

-0.05 (-0.31%)

17:59
11/21/19
11/21
17:59
11/21/19
17:59
Periodicals
Gap to pull Old Navy brand from China in early 2020, Reuters reports »

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  • 21

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  • 05

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LB

L Brands

$17.18

1.78 (11.56%)

17:50
11/21/19
11/21
17:50
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17:50
Hot Stocks
L Brands cancels Victoria's Secret Fashion Show for 'more current platforms' »

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WCC

Wesco

$53.09

-0.02 (-0.04%)

17:47
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11/21
17:47
11/21/19
17:47
Initiation
Wesco initiated at Jefferies »

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MAN

ManpowerGroup

$92.05

-0.355 (-0.38%)

17:47
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11/21
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17:47
Initiation
ManpowerGroup initiated at Jefferies »

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