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IMMP

Immutep

$1.67

-0.01 (-0.60%)

08:07
10/15/19
10/15
08:07
10/15/19
08:07

Immutep reports efficacy data for TACTI-mel Phase 1 clinical study

Immutep Limited announced mature positive efficacy data from its TACTI-mel Phase I clinical study combining its lead product candidate, eftilagimod alpha with KEYTRUDA in metastatic melanoma. TACTI-mel evaluated the combination of efti with anti-PD-1 therapy KEYTRUDA in 24 patients with unresectable or metastatic melanoma. Patients participating in the trial had a very late stage of disease: 75% classified as M1c, 67% had lung metastasis, 50% had liver metastasis, 50% had elevated LDH and many had either a suboptimal response or disease progression with pembrolizumab treatment as a monotherapy. All patients received subcutaneous injections of efti every two weeks, with a treatment duration of up to either six or 12 months. TACTI-mel is a multi-centre, open label clinical trial involving four cohorts of six patients per cohort: Part A includes the first three cohorts testing different dosages of efti in combination with pembrolizumab, with efti treatment given for six months only and commencing at cycle five of pembrolizumab treatment. Part B includes the remaining cohort testing a 30mg dosage of efti given for 12 months in combination with pembrolizumab, starting at cycle 1, day 1 of pembrolizumab treatment. The primary endpoint of the trial is safety and tolerability, with the outcome to determine the recommended dose for a Phase II trial. The trial also evaluated efficacy through Overall Response Rate, tumour shrinkage and Disease Control Rate. Efti has a favourable safety profile in combination with pembrolizumab with no dose-limiting toxicities. The recommended dosage level for a Phase II trial is 30mg of efti, which is the dosage level currently used in the ongoing TACTI-002 Phase II trial. Deep and durable responses have been observed.

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SRPT

Sarepta

$97.45

-3.55 (-3.51%)

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ACB

Aurora Cannabis

$3.29

-0.25 (-7.06%)

17:04
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Earnings
Aurora Cannabis reports Q1 cannabis net revenue down 25% from Q4 at $70.8M »

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OXY

Occidental Petroleum

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, RH

RH

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1.98 (1.14%)

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Berkshire Hathaway takes position in RH, lowers stake in Apple »

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OXY

Occidental Petroleum

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RH

RH

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1.98 (1.14%)

WFC

Wells Fargo

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0.23 (0.43%)

PSX

Phillips 66

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Sirius XM

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AAPL

Apple

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BAC

Bank of America

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KO

Coca-Cola

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AXP

American Express

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CPG

Crescent Point Energy

$3.96

0.035 (0.89%)

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Crescent Point Energy to sell Sasketchewan gas infrastructure assets for $500M »

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Valvoline

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Valvoline raises quarterly dividend 7% to 11.3c per share »

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SYY

Sysco

$81.51

0.27 (0.33%)

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Sysco raises quarterly diviend to 45c from 39c per share »

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NGVC

Natural Grocers

$9.28

0.64 (7.41%)

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Natural Grocers issues recall on organic soybeans due to mold »

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KMPH

KemPharm

$0.51

0.0229 (4.66%)

16:56
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Earnings
KemPharm reports Q3 diluted EPS 6c, consensus (19c) »

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MTD

Mettler-Toledo

$713.22

-8.48 (-1.18%)

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WAT

Waters

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-0.06 (-0.03%)

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NBSE

NeuBase Therapeutics

$5.19

0.04 (0.78%)

, HGV

Hilton Grand Vacations

$35.29

0.05 (0.14%)

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Greenlight raises stake in Brighthouse, cuts stake in Dillard's »

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NBSE

NeuBase Therapeutics

$5.19

0.04 (0.78%)

HGV

Hilton Grand Vacations

$35.29

0.05 (0.14%)

KAR

KAR Auction

$22.80

0.88 (4.01%)

VAL

Valaris

$4.09

-0.25 (-5.76%)

CARS

Cars.com

$12.56

0.48 (3.97%)

BHF

Brighthouse Financial

$40.06

0.055 (0.14%)

CC

Chemours

$18.54

0.2 (1.09%)

GM

General Motors

$36.80

-0.4 (-1.08%)

ADNT

Adient

$20.37

-0.705 (-3.35%)

DDS

Dillard's

$77.04

9.235 (13.62%)

GRBK

Green Brick

$11.69

0.03 (0.26%)

AER

AerCap

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-0.39 (-0.65%)

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BGNE

BeiGene

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-1.25 (-0.63%)

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Breaking Hot Stocks news story on BeiGene 

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PAYS

Paysign

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-0.56 (-4.73%)

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AWK

American Water

$117.90

0.945 (0.81%)

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AVTR

Avantor

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0.36 (2.30%)

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EUSHF

Eurocash

$0.00

(0.00%)

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Eurocash rating change  »

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TMO

Thermo Fisher

$300.82

0.92 (0.31%)

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RH

RH

$175.19

1.98 (1.14%)

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Breaking Hot Stocks news story on RH »

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PTON

Peloton

$25.96

0.015 (0.06%)

, ALC

Alcon

$58.90

-0.17 (-0.29%)

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PTON

Peloton

$25.96

0.015 (0.06%)

ALC

Alcon

$58.90

-0.17 (-0.29%)

ALLY

Ally Financial

$30.83

0.15 (0.49%)

ORCC

Owl Rock

$18.20

0.2 (1.11%)

DIS

Disney

$147.19

-1.5 (-1.01%)

VMC

Vulcan Materials

$141.66

3.04 (2.19%)

CAG

Conagra Brands

$28.45

0.13 (0.46%)

CELG

Celgene

$110.03

-0.42 (-0.38%)

EPC

Edgewell Personal Care

$31.40

-0.815 (-2.53%)

VST

Vistra Energy

$26.34

0.34 (1.31%)

NLY

Annaly Capital

$9.11

0.035 (0.39%)

C

Citi

$73.85

-0.06 (-0.08%)

CZR

Caesars

$12.86

0.09 (0.70%)

VICI

VICI Properties

$24.58

0.24 (0.99%)

MS

Morgan Stanley

$48.61

0.22 (0.45%)

ADM

Archer Daniels

$42.78

-0.04 (-0.09%)

LBRDK

Liberty Broadband

$119.07

0.36 (0.30%)

GOOGL

Alphabet Class A

$1,309.61

13.61 (1.05%)

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RH

RH

$175.19

1.98 (1.14%)

, OXY

Occidental Petroleum

$37.76

-0.36 (-0.94%)

16:40
11/14/19
11/14
16:40
11/14/19
16:40
Hot Stocks
Breaking Hot Stocks news story on RH, Occidental Petroleum »

Buffett's Berkshire…

RH

RH

$175.19

1.98 (1.14%)

OXY

Occidental Petroleum

$37.76

-0.36 (-0.94%)

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16:39
11/14/19
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16:39
11/14/19
16:39
General news
Fed Balance Sheet Level data reported »

Week of 11/13 Fed Balance…

QGEN

Qiagen

$37.31

1.785 (5.03%)

16:38
11/14/19
11/14
16:38
11/14/19
16:38
Initiation
Qiagen initiated  »

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  • 07

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ILMN

Illumina

$298.43

0.32 (0.11%)

16:36
11/14/19
11/14
16:36
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16:36
Initiation
Illumina initiated  »

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