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VRCA

Verrica Pharmaceuticals

$15.00 /

+0.56 (+3.88%)

07:03
10/18/19
10/18
07:03
10/18/19
07:03

Verrica Pharmaceuticals announces presentation of data from VP-102 trials

Verrica Pharmaceuticals announced the presentation of positive data from three abstracts evaluating the efficacy and safety of VP-102, the Company's lead product candidate for the treatment of molluscum contagiosum and common warts. These data are being presented in poster form at the 2019 39th Annual Fall Clinical Dermatology Conference in Las Vegas, NV. Data from a pooled analysis of the Phase 3 CAMP-1 and CAMP-2 clinical studies showed that treatment with VP-102 brought about a statistically significantly higher rate of complete lesion clearance at Day 84 compared to vehicle. Complete clearance of all molluscum lesions at the end of study visit occurred in 50% of subjects treated with VP-102, as compared to 15.6% for vehicle. In addition, mean lesion counts decreased by 76% for subjects in the VP-102 group, compared to a 0.3% decrease in the vehicle arm by the EOS visit. VP-102 was well-tolerated, and adverse events were primarily mild to moderate in intensity, with the most common adverse events related to the pharmacodynamic action of cantharidin, including application site vesicles, pruritus, pain, erythema, and scab. Rates of discontinuation of study medication due to an adverse event were low. A second pooled analysis of the CAMP studies evaluated the time course and percentage of subjects with greater than 75% and greater than 90% reduction in lesions at the EOS visit in the intent-to-treat population. Data demonstrated that as early as Day 21, greater than 75% and greater than 90% lesion clearance rates were statistically significantly higher with VP-102 treatment as compared to vehicle. At EOS, 77.7% of VP-102 subjects achieved greater than 75% reduction in lesions compared to 34.9% for vehicle, and 65.8% of VP-102 subjects achieved greater than 90% reduction of lesions compared to 27.1% for vehicle. The Phase 2 COVE-1 open label study evaluated the efficacy and safety of VP-102 in subjects with up to six common warts in two cohorts. Cohort 2 subjects receiving VP-102 showed a change of -50.9% of common warts and 51.4% of subjects showed complete clearance of warts at the primary endpoint of Day 84. Clinical response was maintained through the follow-up period, with a 45.5% mean reduction of warts compared to baseline, and 40% of subjects showing complete clearance at Day 147. Due to the higher complete clearance rates observed in Cohort 2, Verrica intends to use the treatment regimen of Cohort 2 in future Phase 3 studies. In the COVE-1 study, VP-102 showed a favorable tolerability and acceptable safety profile. The most common adverse events were mild to moderate in severity, and included application site blistering, pain, pruritus, erythema, and scab, and were considered related to the pharmacodynamic action of cantharidin.

VRCA Verrica Pharmaceuticals
$15.00 /

+0.56 (+3.88%)

06/27/19 H.C. Wainwright
Verrica Pharmaceuticals price target raised to $23 from $20 at H.C. Wainwright
06/27/19 Jefferies
Verrica reported positive Phase 2 results in underserved market, says Jefferies
05/15/19 H.C. Wainwright
Verrica opportunity in molluscum 'far undervalued," says H.C. Wainwright
02/21/19
Fly Intel: Top five analyst initiations

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