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PRVB

Provention Bio

$6.09

-0.48 (-7.31%)

07:09
10/22/19
10/22
07:09
10/22/19
07:09

Provention Bio announces results from Phase 2a PRINCE clinical trial

Provention Bio announced top-line results from its randomized, placebo-controlled Phase 2a PRINCE clinical trial evaluating twice-daily PRV-6527, an oral Colony Stimulating Factor-1 Receptor, or CSF-1R, small molecule inhibitor. The PRINCE study enrolled 93 moderate-to-severe Crohn's disease patients who were either naive to biologic therapy, ~70%, or who had previously failed at least one biologic drug, ~30%. The primary efficacy endpoint of the study was the change in the Crohn's Disease Activity Index, or CDAI, score at week 12. While PRV-6527 demonstrated a substantial improvement in this symptom driven score at week 12, it did not differentiate from placebo. This high placebo response is deemed to be related to the background medication used, ~85%, in the study's predominantly biologic-naive population. RV-6527 was associated with improvements in several key secondary objective endpoints in the steroid-free population, including mucosal endoscopy and tissue histology. PRV-6527 was found to be generally safe and well tolerated, with no drug-related serious adverse events.

PRVB Provention Bio
$6.09

-0.48 (-7.31%)

01/18/19
HCWC
01/18/19
INITIATION
Target $7.5
HCWC
Buy
Provention Bio initiated with a Buy at H.C. Wainwright
H.C. Wainwright analyst Raghuram Selvaraju started Provention Bio with a Buy rating and $7.50 price target. Provention is a "virtual, rapidly emerging biotechnology company focused on treatment of inflammatory and autoimmune diseases," Selvaraju tells investors in a research note. He sees "substantial" market opportunities for the company that underserved by existing drugs.
02/22/19
LEER
02/22/19
INITIATION
Target $6
LEER
Outperform
Provention Bio initiated with an Outperform at SVB Leerink
SVP Leerink analyst Pasha Sarraf initiated Provention Bio with an Outperform rating and $6 price target. The company's small team of experienced drug developers is aggregating assets through leveraged strategic partnerships, Sarraf tells investors in a research note.
06/10/19
CHDN
06/10/19
INITIATION
Target $20
CHDN
Buy
Provention Bio initiated with a Buy at Chardan
Chardan initiated Provention Bio with a Buy and $20 price target.
08/05/19
LEER
08/05/19
NO CHANGE
Target $35
LEER
Outperform
Provention Bio price target raised to $35 from $17 at SVB Leerink
SVB Leerink analyst Pasha Sarraf raised his price target for Provention Bio to $35 from $17 after the FDA granted breakthrough designation for teplizumab. The analyst believes the company will now pursue an expedited approval for teplizumab using the At-Risk trial and other historical datasets for registrational purposes, with a type I prevention indication. Sarraf reiterates an Outperform rating on the shares.

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