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ATXI

Avenue Therapeutics

$5.98 /

+0.61 (+11.36%)

08:39
10/28/19
10/28
08:39
10/28/19
08:39

Avenue Therapeutics announces publication of IV tramadol Phase 1 clinical data

Avenue Therapeutics announced that its Phase 1 data on intravenous tramadol has been published in the peer-reviewed journal Clinical Pharmacology in Drug Development. Based on the results of the study, Avenue chose the IV tramadol 50 mg dosing regimen for Phase 3 development. The objective of this Phase 1, open-label, single investigational center, three-treatment, three-period, multidose crossover study was to compare the pharmacokinetics of two novel IV tramadol dosing regimens to oral tramadol 100 mg given every six hours, the highest approved oral dosage in the United States. Compared to the oral regimen, IV tramadol 50 mg administered at hours 0, 2, and 4 and every 4 hours thereafter reached initial tramadol peak serum concentration (Cmax) more rapidly, while resulting in similar overall steady-state Cmax and area under the plasma concentration-time curve, and that the primary metabolite, M1, had lower area under the plasma concentration-time curve and Cmax than for the oral regimen. The IV tramadol 50 mg dosing regimen was well tolerated, with adverse event profiles consistent with the known pharmacological effects of tramadol.

TODAY'S FREE FLY STORIES

General News
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Earnings
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  • 02
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Periodicals
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On The Fly
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Conference/Events
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Hot Stocks
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Brookfield Asset…

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Hot Stocks
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Leidos announced it has…

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Hot Stocks
EQT Corporation changes annual meeting to virtual only format » 16:31
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EQT Corporation announced…

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Hanover Insurance names Dennis Kerrigan new General Counsel » 16:30
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The Hanover Insurance…

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Conference/Events
Morgan Stanley economists/strategists to hold analyst/industry conference call » 16:30
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04/01
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Chief Economist Ahya,…

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Options
Preliminary option volume of 23.5M today » 16:30
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Preliminary option volume…

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Hot Stocks
Standex terminates proposed Torotel acquisition » 16:28
04/01/20
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Standex

$45.63 /

-2.64 (-5.47%)

Standex International…

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