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KPTI

Karyopharm

$12.57

0.86 (7.34%)

07:31
11/04/19
11/04
07:31
11/04/19
07:31

Karyopharm expects to submit NDA for selinexor by end of 2019

Following the positive results from the Phase 2b SADAL study that were first presented at the America Society of Hematology 2018 Annual Meeting and then updated in June at the 2019 International Conference on Malignant Lymphoma, Karyopharm expects to submit a New Drug Application to the FDA by the end of 2019 requesting accelerated approval for selinexor as a treatment for patients with relapsed or refractory DLBCL after at least two prior multi-agent therapies and who are ineligible for stem cell transplantation including CAR-T therapy. The Company also expects to submit an MAA to the EMA in 2020 requesting conditional approval for selinexor in the same indication. In addition to orphan drug designation, selinexor was granted fast track designation for this indication by the FDA in 2018.

  • 04

    Nov

  • 07

    Dec

KPTI Karyopharm
$12.57

0.86 (7.34%)

07/23/19
JPMS
07/23/19
UPGRADE
Target $16
JPMS
Overweight
Karyopharm upgraded to Overweight from Neutral at JPMorgan
JPMorgan analyst Eric Joseph upgraded Karyopharm Therapeutics to Overweight from Neutral and doubled his price target for the shares to $16 from $8. The analyst says his doctor survey supports a "strong" Xpovio launch and long-term outlook.
07/23/19
JPMS
07/23/19
UPGRADE
Target $16
JPMS
Overweight
JPMorgan upgrades Karyopharm after doctor survey, doubles price target
JPMorgan analyst Eric Joseph upgraded Karyopharm Therapeutics to Overweight from Neutral and doubled his price target for the shares to $16 from $8. The analyst conducted a U.S. physician survey assessing Xpovio anticipated use in the approved indication of penta-refractory myeloma, as well as expectations around use in earlier-line settings. The survey of 15 doctors data show favorable reception to Xpovio's clinical profile, with 75% respondents intending to write Xpovio for PR-MM within the next 12 months, Joseph tells investors in a research note. Importantly, nearly all respondents described the side-effect profile as manageable, which is "very encouraging," adds the analyst. He sees a favorable reward/risk profile for Karyopharm shares at current levels.
07/23/19
07/23/19
UPGRADE

Fly Intel: Top five analyst upgrades
Catch up on today's top five analyst upgrades with this list compiled by The Fly: 1. Snap (SNAP) upgraded to Buy from Hold at Stifel with analyst John Egbert saying the company's sales reorganization efforts were already reflected in its prior guidance and the daily active user checks for the quarter appear to be positive. 2. Murphy Oil (MUR) upgraded to Buy from Neutral at Goldman Sachs with analyst Brian Singer saying he believes the company's free cash flow generation is being underappreciated by the market. 3. Karyopharm (KPTI) upgraded to Overweight from Neutral at JPMorgan with analyst Eric Joseph saying he conducted a U.S. physician survey assessing Xpovio anticipated use in the approved indication of penta-refractory myeloma, as well as expectations around use in earlier-line settings. The survey of 15 doctors data show favorable reception to Xpovio's clinical profile, with 75% respondents intending to write Xpovio for PR-MM within the next 12 months. 4. Smith & Nephew (SNN) upgraded to Buy from Hold at Berenberg with analyst Tom Jones saying he believes management and process changes have addressed the company's execution issues. He views Smith & Nephew's portfolio as "highly competitive." 5. Columbia Sportswear (COLM) upgraded to Buy from Neutral at BofA/Merrill with analyst Alexander Perry citing his outlook for the company to generate "significant near-term revenue and EPS upside" amid a strong wholesale environment for Columbia's apparel as well as its "significant" under-penetration in footwear. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.
09/24/19
BARD
09/24/19
NO CHANGE
Target $25
BARD
Outperform
Karyopharm Xpovio launch appears strong, says Baird
Baird analyst Michael Ulz said his physician survey regarding the Karyopharm launch of Xpovio is indicating strong early trends. The analyst said there appears to be an early robust, broad adoption with meaningful share gains ahead, and the safety profile is manageable. Ulz said he sees upside to estimates and he reiterated his Outperform rating and $25 price target on Karyopharm shares.

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RCKT

Rocket Pharmaceuticals

$22.37

2.61 (13.21%)

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ARGX

Argenx

$147.31

-2.56 (-1.71%)

, JNJ

Johnson & Johnson

$140.36

0.79 (0.57%)

18:03
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18:03
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18:03
Recommendations
Argenx, Johnson & Johnson analyst commentary  »

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ARGX

Argenx

$147.31

-2.56 (-1.71%)

JNJ

Johnson & Johnson

$140.36

0.79 (0.57%)

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BLUE

Bluebird Bio

$79.51

-1.24 (-1.54%)

, JNJ

Johnson & Johnson

$140.36

0.79 (0.57%)

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17:58
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BLUE

Bluebird Bio

$79.51

-1.24 (-1.54%)

JNJ

Johnson & Johnson

$140.36

0.79 (0.57%)

AMGN

Amgen

$233.74

0.3 (0.13%)

BMY

Bristol-Myers

$59.94

0.435 (0.73%)

REGN

Regeneron

$372.26

4.02 (1.09%)

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BGNE

BeiGene

$186.89

-2.3 (-1.22%)

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LLY

Eli Lilly

$119.59

-0.175 (-0.15%)

16:34
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BMY

Bristol-Myers

$59.94

0.435 (0.73%)

16:32
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16:32
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Bristol-Myers announces data from multiple liso-cel studies at ASH meeting »

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QURE

uniQure

$66.06

1.5 (2.32%)

16:26
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16:26
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uniQure reports 1-year follow-up data from etranacogene dezaparvovec study »

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  • 09

    Dec

FTSV

Forty Seven

$14.40

0.23 (1.62%)

15:56
12/08/19
12/08
15:56
12/08/19
15:56
Conference/Events
Forty Seven to hold an investor event »

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  • 09

    Dec

AQST

Aquestive Therapeutics

$8.02

-0.34 (-4.07%)

15:50
12/08/19
12/08
15:50
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15:50
Conference/Events
Aquestive Therapeutics holds analyst & investor event w/conference call hookup »

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  • 09

    Dec

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    Dec

APRE

Aprea Therapeutics

$26.20

1.995 (8.24%)

15:23
12/08/19
12/08
15:23
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15:23
Conference/Events
Aprea Therapeutics to hold a clinical update meeting »

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  • 08

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BPMC

Blueprint Medicines

$78.50

3.92 (5.26%)

15:18
12/08/19
12/08
15:18
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15:18
Conference/Events
Blueprint Medicines to hold an anlayst and investor event »

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  • 08

    Dec

IFF

International Flavors

$142.03

0.21 (0.15%)

, DD

DuPont

$63.60

1.6 (2.58%)

13:47
12/08/19
12/08
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13:47
Periodicals
International Flavors in talks to buy DuPont nutrition unit, Bloomberg reports »

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IFF

International Flavors

$142.03

0.21 (0.15%)

DD

DuPont

$63.60

1.6 (2.58%)

KRYAY

Kerry Group

$0.00

(0.00%)

03/08/13
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CHWRF

China Tower

$0.00

(0.00%)

13:40
12/08/19
12/08
13:40
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13:40
Upgrade
China Tower rating change at Deutsche Bank »

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PRNB

Principia Biopharma

$37.30

0.86 (2.36%)

13:37
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13:37
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Principia Biopharma analyst commentary at Stifel »

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DY

Dycom

$50.93

0.495 (0.98%)

12:48
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12:48
Syndicate
Dycom withdraws senior notes offering due to market conditions »

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IMV

IMV Inc.

$2.92

0.07 (2.46%)

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KURA

Kura Oncology

$15.67

0.48 (3.16%)

12:27
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  • 08

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PTLA

Portola Pharmaceuticals

$29.22

0.86 (3.03%)

12:24
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Portola presents interim results from Phase 2a study of cerdulatinib »

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  • 08

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11:25
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Conference/Events
Piper Jaffray biotech analysts to hold a KOL luncheon »

Biotech Analysts hold a…

FATE

Fate Therapeutics

$13.64

0.07 (0.52%)

10:49
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STOK

Stoke Therapeutics

$28.91

3.99 (16.01%)

10:04
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AUTL

Autolus Therapeutics

$14.60

-0.18 (-1.22%)

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  • 09

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AGIO

Agios Pharmaceuticals

$40.93

0.81 (2.02%)

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ZIOP

Ziopharm

$5.16

0.06 (1.18%)

09:20
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  • 08

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TGTX

TG Therapeutics

$7.11

-0.57 (-7.42%)

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  • 09

    Dec

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