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VCNX

Vaccinex

$4.86

(0.00%)

10:44
11/10/19
11/10
10:44
11/10/19
10:44

Vaccinex presents updated interim data from Phase 1b/2 study

Vaccinex announced that updated interim data of the Phase 1b/2 study of pepinemab in combination with anti-PD-L1 checkpoint inhibitor, Bavencio, in non-small cell lung cancer is being reported during a poster presentation on Saturday, November 9 at the 34th Annual Meeting of The Society for Immunotherapy of Cancer. Importantly, comparative analysis of available pre-treatment and on-treatment biopsies in a subset of subjects indicate that there is increased CD8+ T cell influx into tumors following combination therapy in patients experiencing a partial response or stable disease, suggesting a favorable treatment-related change in the tumor micro-environment. Tumor was absent or greatly reduced in on-treatment biopsies from these subjects. No concerning safety signals with the combination of pepinemab and avelumab have been identified by investigators to date. One dose limiting toxicity, a grade 3 pulmonary embolism, occurred. This resolved and did not recur in that same subject or additional subjects in any cohort. In addition, there have been no dropouts or discontinuations due to toxicity. Dr. Maurice Zauderer, CEO of Vaccinex, commented, "We are very pleased that patients appear to be experiencing durable clinical benefit from the combination of pepinemab plus avelumab, in many cases even after progression on prior immune checkpoint inhibitor therapy. The many patients who do not respond to single agent immunotherapy and others who relapse following single agent immunotherapy represent important unmet needs for NSCLC, and our data suggest that the combination treatment may overcome inherent or acquired resistance to anti-PD-1/PD-L1 therapy."

TODAY'S FREE FLY STORIES

MMNFF

MedMen

$0.00

(0.00%)

14:25
12/12/19
12/12
14:25
12/12/19
14:25
Conference/Events
MedMen management to meet with Cantor Fitzgerald »

Analyst Pablo Zuanic…

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  • 12

    Dec

FB

Facebook

$200.86

-1.37 (-0.68%)

14:22
12/12/19
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14:22
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14:22
Periodicals
FTC considers injunction to block Facebook policies on app integration, WSJ says »

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AMRX

Amneal Pharmaceuticals

$5.00

1.515 (43.47%)

14:17
12/12/19
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14:17
Downgrade
Amneal Pharmaceuticals rating change  »

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LUV

Southwest

$54.65

0.67 (1.24%)

, BA

Boeing

$346.36

-3.64 (-1.04%)

14:17
12/12/19
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14:17
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14:17
Periodicals
Southwest weighs another delay in 737 MAX's return to schedule, Bloomberg says »

Southwest Airlines (LUV)…

LUV

Southwest

$54.65

0.67 (1.24%)

BA

Boeing

$346.36

-3.64 (-1.04%)

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$NSD

NASDAQ Market Internals

$0.00

(0.00%)

14:17
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14:17
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14:17
Technical Analysis
NASDAQ market internals summary »

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FB

Facebook

$200.80

-1.43 (-0.71%)

14:16
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14:16
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Periodicals
FTC considering injunction against Facebook, WSJ says »

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$NYE

NYSE Market Internals

$0.00

(0.00%)

14:16
12/12/19
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14:16
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14:16
Technical Analysis
NYSE market internals summary »

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ITCI

Intra-Cellular

$12.67

0.53 (4.37%)

14:15
12/12/19
12/12
14:15
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14:15
Options
Intra Cellular Therapies put volume heavy and directionally bearish »

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  • 27

    Dec

TISI

Team

$15.98

-0.03 (-0.19%)

14:14
12/12/19
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14:14
Initiation
Team initiated  »

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BTI

British American Tobacco

$39.37

-0.12 (-0.30%)

, MO

Altria Group

$50.38

0.075 (0.15%)

14:11
12/12/19
12/12
14:11
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14:11
Periodicals
CDC says many brands likely responsible for vaping-related injuries, Verge says »

The Centers for Disease…

BTI

British American Tobacco

$39.37

-0.12 (-0.30%)

MO

Altria Group

$50.38

0.075 (0.15%)

PM

Philip Morris

$84.20

-0.8 (-0.94%)

IMBBY

Imperial Brands

$0.00

(0.00%)

03/08/13
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  • 30

    Jan

NXGN

NextGen Healthcare

$17.10

-1.01 (-5.58%)

14:11
12/12/19
12/12
14:11
12/12/19
14:11
Hot Stocks
NextGen Healthcare down 6% after guiding 'relatively flat' earnings until FY23 »

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  • 12

    Dec

AMRX

Amneal Pharmaceuticals

$5.04

1.555 (44.62%)

14:09
12/12/19
12/12
14:09
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14:09
Downgrade
Amneal Pharmaceuticals rating change  »

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NXGN

NextGen Healthcare

$17.39

-0.72 (-3.98%)

14:08
12/12/19
12/12
14:08
12/12/19
14:08
Earnings
NextGen Healthcare lowers FY20 EPS outlook, raises low-end of FY20 revenue view »

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  • 12

    Dec

APO

Apollo Global

$44.31

-0.66 (-1.47%)

, GE

General Electric

$11.36

0.375 (3.42%)

14:06
12/12/19
12/12
14:06
12/12/19
14:06
Hot Stocks
Apollo, Athene close the acquisition of GE Capital's PK AirFinance debt business »

Apollo Global Management…

APO

Apollo Global

$44.31

-0.66 (-1.47%)

GE

General Electric

$11.36

0.375 (3.42%)

ATH

Athene Holding

$45.09

1.12 (2.55%)

03/08/13
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  • 29

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  • 26

    Feb

CIEN

Ciena

$41.74

6.29 (17.74%)

14:06
12/12/19
12/12
14:06
12/12/19
14:06
Recommendations
Ciena analyst commentary  »

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  • 12

    Dec

BMRN

BioMarin

$80.03

1.25 (1.59%)

14:05
12/12/19
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Options
BioMarin call volume above normal and directionally bullish »

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TXMD

TherapeuticsMD

$2.39

0.01 (0.42%)

, AMRX

Amneal Pharmaceuticals

$5.15

1.66 (47.63%)

13:59
12/12/19
12/12
13:59
12/12/19
13:59
Recommendations
TherapeuticsMD, Amneal Pharmaceuticals, Merck analyst commentary  »

Stifel says…

TXMD

TherapeuticsMD

$2.39

0.01 (0.42%)

AMRX

Amneal Pharmaceuticals

$5.15

1.66 (47.63%)

MRK

Merck

$89.27

0.31 (0.35%)

03/08/13
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    Mar

HURN

Huron

$69.15

0.23 (0.33%)

13:57
12/12/19
12/12
13:57
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13:57
Conference/Events
Huron management to meet with Benchmark »

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  • 17

    Dec

13:55
12/12/19
12/12
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Conference/Events
The FDIC to hold a Board Meeting »

Board of Directors…

MLNT

Melinta Therapeutics

$1.71

0.15 (9.62%)

13:48
12/12/19
12/12
13:48
12/12/19
13:48
Hot Stocks
FDA approves Melinta Therapeutics sNDA for Orbactiv for injection »

A letter posted by the…

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TTWO

Take-Two

$122.30

-0.08 (-0.07%)

13:45
12/12/19
12/12
13:45
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13:45
Options
TakeTwo Interactive Software call volume above normal and directionally bullish »

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  • 13

    Dec

  • 13

    Dec

KW

Kennedy Wilson

$22.26

-0.25 (-1.11%)

13:44
12/12/19
12/12
13:44
12/12/19
13:44
Hot Stocks
Kennedy Wilson raises quarterly dividend 5% to 22c per share »

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  • 08

    Jan

SPY

SPDR S&P 500 ETF Trust

$316.35

1.94 (0.62%)

, SPX

S&P 500

$0.00

(0.00%)

13:38
12/12/19
12/12
13:38
12/12/19
13:38
Periodicals
WH Press Secretary says President to hold trade meeting at 2:30, CNBC reports »

CNBC political reporter…

SPY

SPDR S&P 500 ETF Trust

$316.35

1.94 (0.62%)

SPX

S&P 500

$0.00

(0.00%)

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GILD

Gilead

$67.62

0.48 (0.71%)

13:36
12/12/19
12/12
13:36
12/12/19
13:36
Periodicals
PrEP4All says USPTO adviser showed 'bias' in favor of Gilead, STAT reports »

An AIDS activist group…

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BCS

Barclays

$8.98

0.01 (0.11%)

13:35
12/12/19
12/12
13:35
12/12/19
13:35
Options
Barclays put volume heavy and directionally bearish »

Bearish flow noted in…

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