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NXTC

NextCure

$83.35

3.47 (4.34%)

11:40
11/10/19
11/10
11:40
11/10/19
11:40

NextCure presents updated data from NC318 Phase 1/2 clinical trial

NextCure announced that updated clinical results from the Phase 1 portion of its ongoing trial with NC318, a monoclonal antibody targeting Siglec-15, or S15, were presented at the SITC annual meeting. S15 is a novel immunomodulatory protein that is expressed on highly immunosuppressive cells called M2 macrophages and on tumor cells. In addition, NextCure announced the initiation of the Phase 2 portion of its ongoing Phase 1/2 clinical trial of NC318. "NC318 has been well tolerated in the Phase 1 trial, and the only dose-limiting toxicity was a grade 3 pneumonitis in the 1,600 mg cohort," said Kevin Heller, M.D., NextCure's Chief Medical Officer. "It is encouraging to see single-agent activity among NSCLC patients refractory to PD-1 therapies, including a durable complete response and a durable partial response. Given what appears to be the non-overlapping expression of PD-L1 and S15, the results to date support the potential of NC318 to block S15-mediated immune suppression among a patient population unlikely to respond to PD-1/PD-L1-directed therapies."

NXTC NextCure
$83.35

3.47 (4.34%)

06/03/19
MSCO
06/03/19
INITIATION
Target $25
MSCO
Overweight
Morgan Stanley starts NextCure with an Overweight rating, $25 price target
As previously reported, Morgan Stanley initiated NextCure with an Overweight rating and $25 price target, with analyst Jeffrey Hung telling investors that he sees a rationale to believe NC318 could work as a means to prevent immune suppression by blocking S15. 60-70% of patients do not respond to checkpoint inhibitors, leaving a significant unmet medical need, and NextCure's scientific founder, Dr. Lieping Chen, also discovered PD-L1, giving Hung greater confidence in the rationale for NC318 and NC410, he tells investors.
07/09/19
BOFA
07/09/19
INITIATION
Target $25
BOFA
Buy
NextCure initiated with a Buy at BofA/Merrill
BofA/Merrill analyst Alec Stranahan started NextCure with a Buy rating and $25 price target. The company has developed a unique drug target discovery platform to identify the next generation of immunotherapies, Stranahan tells investors in a research note. Further, the analyst believes NextCure's cash position will likely be sufficient to advance therapies to late stage clinical trials.
07/10/19
PIPR
07/10/19
NO CHANGE
Target $26
PIPR
Overweight
NextCure should be owned ahead of NC318 data, says Piper Jaffray
Piper Jaffray analyst Edward Tenthoff recommends owning shares of NextCure ahead of the full Phase I data for NC318 and Phase II expansion cohorts in Q4. NC318 targets Siglec-15 and is differentially expressed from PD-L1 on tumor cells, Tenthoff tells investors in a research note. NC318 achieved one partial response and six patients with stable disease for an "impressive" early disease control rate of 54%, adds the analyst. He reiterates an Overweight rating on NextCure with a $26 price target.
09/04/19
PIPR
09/04/19
NO CHANGE
Target $54
PIPR
Overweight
NextCure price target raised to $54 from $26 at Piper Jaffray
Piper Jaffray analyst Edward Tenthoff more than doubled his price target for NextCure to $54 from $26 and reiterates an Overweight rating on the shares. The stock closed Wednesday up 7% to $39.43. Enrollment remains ongoing in the Phase I dose escalation study of NC318 targeting Siglec-15 in advanced solid tumors, Tenthoff tells investors in a research note. While early, NC318 has shown initial signs of activity including, adds the analyst. Tenthoff increased his value for NC318 ahead of Phase I data readout in Q4.

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BR

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MCD

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MCD

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SYF

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KEY

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AMGN

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CSCO

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RCL

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MRK

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MSFT

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AMZN

Amazon.com

$1,737.49

-17.22 (-0.98%)

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MSFT

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AAPL

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CI

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CNC

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CVS

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HUM

Humana

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UNH

UnitedHealth

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13.68 (5.35%)

WCG

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10.155 (3.36%)

HNT

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$0.00

(0.00%)

MOH

Molina Healthcare

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7.3 (5.97%)

ANTM

Anthem

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HCA

HCA Healthcare

$137.98

3.51 (2.61%)

CYH

Community Health

$3.12

0.25 (8.71%)

LPNT

LifePoint

$0.00

(0.00%)

UHS

Universal Health

$144.30

3.13 (2.22%)

THC

Tenet

$30.55

1.08 (3.66%)

GM

General Motors

$36.87

0.07 (0.19%)

FCAU

Fiat Chrysler

$16.02

0.04 (0.25%)

TM

Toyota

$144.29

1.16 (0.81%)

F

Ford

$8.96

0.16 (1.82%)

HMC

Honda

$28.99

0.155 (0.54%)

VWAGY

Volkswagen

$0.00

(0.00%)

BMWYY

BMW

$0.00

(0.00%)

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MDCO

The Medicines Co.

$51.92

1.03 (2.02%)

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CVET

Covetrus

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CMCSK

Comcast

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CWK

Cushman & Wakefield

$19.10

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  • 12

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LMT

Lockheed Martin

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ESCA

Escalade

$10.90

-0.09 (-0.82%)

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CZR

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  • 15

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EGRX

Eagle Pharmaceuticals

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FN

Fabrinet

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  • 12

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TEUM

Pareteum

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HEXO

Hexo

$1.78

-0.1 (-5.32%)

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AMGN

Amgen

$220.84

2.29 (1.05%)

, CELG

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$110.02

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AMGN

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$220.84

2.29 (1.05%)

CELG

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$110.02

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BMY

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$58.61

0.11 (0.19%)

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RAVE

Rave Restaurant

$1.44

-0.79 (-35.43%)

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CHAP

Chaparral Energy

$0.89

-0.0521 (-5.52%)

16:46
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16:45
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General news
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CI

Cigna

$196.08

6.41 (3.38%)

, CNC

Centene

$57.57

2.91 (5.32%)

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On The Fly
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CI

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$196.08

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CNC

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$57.57

2.91 (5.32%)

CVS

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HUM

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UNH

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WCG

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$312.01

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HNT

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$0.00

(0.00%)

MOH

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$129.60

7.3 (5.97%)

ANTM

Anthem

$298.18

16.14 (5.72%)

HCA

HCA Healthcare

$137.98

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CYH

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$3.12

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LPNT

LifePoint

$0.00

(0.00%)

UHS

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$144.30

3.13 (2.22%)

NVDA

Nvidia

$204.12

-5.76 (-2.74%)

AMZN

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$1,739.33

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MSFT

Microsoft

$149.95

1.89 (1.28%)

UAA

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$17.78

0.65 (3.79%)

UA

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$15.97

0.41 (2.64%)

AMRN

Amarin

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JNJ

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GOOG

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$1,334.01

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GOOGL

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$1,333.33

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ORCL

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RH

RH

$188.73

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QGEN

Qiagen

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FTCH

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THC

Tenet

$30.55

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TORC

resTORbio

$1.10

-6.83 (-86.13%)

ACB

Aurora Cannabis

$2.72

-0.57 (-17.33%)

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NYT

New York Times

$31.60

0.44 (1.41%)

16:41
11/15/19
11/15
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16:41
Hot Stocks
New York Times CEO sells 66,000 class A common shares »

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  • 09

    Dec

WEX

Wex

$200.52

4.61 (2.35%)

16:41
11/15/19
11/15
16:41
11/15/19
16:41
Hot Stocks
Wex director Morris sells 3K shares of common stock »

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