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NKTR

Nektar

$20.04

1.34 (7.17%)

11:43
11/10/19
11/10
11:43
11/10/19
11:43

Nektar presents new clinical, preclinical data from immuno-oncology pipeline

Nektar Therapeutics announced the presentation of five clinical and preclinical data abstracts focused on its immuno-oncology portfolio at the 2019 Society for Immunotherapy of Cancer Annual Meeting. New clinical results from the PIVOT-02 Phase 1/2 study were shared in an oral presentation titled, "Clinical activity of BEMPEG plus NIVO in previously untreated patients with metastatic melanoma: updated results from the Phase 1/2 PIVOT-02 Study" during the Combination Phase 1-2 Clinical Trials Session on Saturday, November 9th. Additional preclinical data presented at the annual meeting highlighted NKTR-255, an IL-15 agonist discovered by Nektar. The presentations demonstrated that NKTR-255 enhanced activity of antibody-dependent cellular cytotoxicity against tumor cells in vitro, and that it also enhanced in vivo efficacy of ADCC-inducing antibodies in models of human solid tumors. NKTR-255 is designed to engage the IL-15 pathway to stimulate and expand natural killer cells and promote the survival and expansion of memory CD8+ T cells without inducing suppressive regulatory T cells. NKTR-255 is currently being evaluated in a Phase 1/2 clinical trial in patients with either relapsed or refractory Non-Hodgkin's lymphoma or multiple myeloma. "The data presented at this year's SITC meeting continue to showcase the potential of our I-O portfolio, most notably our key IL-2 pathway program, bempeg, and our new IL-15 pathway program, NKTR-255," said Jonathan Zalevsky, Ph.D., Chief Research & Development Officer at Nektar. "The 18-month follow-up data presentation for the Stage IV melanoma patients in our PIVOT-02 study reinforces the promise of BEMPEG and NIVO to work synergistically to achieve a deepening of response over time, while maintaining a favorable safety and tolerability profile. We're pleased that at this 18 month timepoint, 85% of patients who achieved responses have ongoing responses and median PFS has not yet been reached."

  • 10

    Nov

NKTR Nektar
$20.04

1.34 (7.17%)

10/23/19
OPCO
10/23/19
INITIATION
Target $18
OPCO
Perform
Nektar initiated with a Perform at Oppenheimer
Oppenheimer analyst Jay Olson initiated coverage of Nektar with a Perform rating and $18 price target.
10/23/19
OPCO
10/23/19
INITIATION
Target $18
OPCO
Perform
Oppenheimer starts Nektar at Perform, calls shares fairy valued
Oppenheimer analyst Jay Olson initiated coverage of Nektar with a Perform rating and $18 price target. The shares are fairly valued at current levels, representing a "reasonable risk-reward balance" given Nektar's dependence on bempeg combination trials and potential upside from other drug candidates, Olson tells investors in a research note. The analyst thinks bempeg has a "below-average probability of success.:
10/24/19
10/24/19
INITIATION

Fly Intel: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. Peloton (PTON) initiated with an Outperform at Bernstein. 2. Lyft (LYFT) initiated with an Equal Weight at Morgan Stanley. 3. Nektar (NKTR) initiated with a Perform at Oppenheimer. 4. Kellogg (K) initiated with an In Line at Evercore ISI. 5. Pitney Bowes (PBI) initiated with a Buy at National Securities. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.
11/07/19
PIPR
11/07/19
NO CHANGE
Target $35
PIPR
Overweight
Nektar price target lowered to $35 from $50 at Piper Jaffray
Piper Jaffray analyst Tyler Van Buren lowered his price target for Nektar Therapeutics (NKTR) to $35 from $50 citing trial timeline delays following the company's Q3 results. The analyst, however, keeps an Overweight rating on the shares. Three of six planned registrational trials are ongoing with partner Bristol-Myers (BMY), and management on the call updated the timelines for topline readouts in these trials, which are delayed approximately a year, says Van Buren. He looks forward to the melanoma/PIVOT-02 cohort update at SITC this weekend and is "encouraged to see more of the pipeline advance into clinical development," saying Nektar continues to diversify beyond bempeg.

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