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MRTX

Mirati Therapeutics

$104.80

6.81 (6.95%)

11:48
11/10/19
11/10
11:48
11/10/19
11:48

Mirati presents data from sitravatinib in combination with nivolumab trials

Mirati Therapeutics announced the presentation of initial data from its ongoing Phase 2 clinical trial of sitravatinib in combination with nivolumab in metastatic urothelial cancer patients with documented progression on a platinum-chemotherapy and checkpoint inhibitor. The data were presented in an oral presentation at the Society of Immunotherapy of Cancer 34th Annual Meeting. Preliminary results from the ongoing Phase 1 study of neoadjuvant sitravatinib combined with nivolumab in patients with resectable squamous cell carcinoma of the oral cavity, SNOW trial, were also presented in a poster session. The preliminary data suggest that the combination of neoadjuvant sitravatinib and nivolumab is safe and active in patients with squamous cell carcinoma of the oral cavity who are candidates for resection. Tumor reduction was observed in all eight patients who were eligible for evaluation, including one complete pathological response. All patients received postoperative radiation therapy, and none required postoperative chemotherapy. With a median follow-up of 31.4 weeks, all patients are alive with no disease recurrence to date. In most patients, treatment with sitravatinib led to a decrease in myeloid-derived suppressor cells and a shift towards M1-type macrophages in the tumor microenvironment, supporting previous preclinical findings. "Sitravatinib is a spectrum-selective kinase inhibitor that potently inhibits receptor tyrosine kinases, including TAM family receptors that has the potential to increase responsiveness in patients whose tumors are resistant to checkpoint inhibitors. The initial efficacy data from the Phase 2 clinical trial presented today in patients with checkpoint refractory mUC is promising and extends the clinical benefit data beyond what has already been demonstrated by sitravatinib combined with nivolumab in checkpoint refractory non-small cell lung cancer," said Charles Baum, M.D., CEO of Mirati. "In addition, we are evaluating sitravatinib in patients who have progressed on checkpoint therapy, including those with NSCLC and renal cell cancer, and we continue to expand development efforts of sitravatinib through our collaboration with BeiGene in multiple indications including NSCLC, renal cell cancer, hepatocellular cancer, ovarian cancer, and gastric cancer."

MRTX Mirati Therapeutics
$104.80

6.81 (6.95%)

10/29/19
CANT
10/29/19
NO CHANGE
Target $85
CANT
Overweight
Mirati Therapeutics price target raised to $85 from $81 at Cantor Fitzgerald
Cantor Fitzgerald analyst Varun Kumar raised his price target for Mirati Therapeutics to $85 from $81 saying the company's agent provided the initial proof-of-concept data in non-small cell lung cancer and in colorectal cancer patients with KRAS G12C mutation. This should be seen positively overall for the stock, says Kumar, who reiterates a Neutral rating on Mirati.
10/29/19
HCWC
10/29/19
NO CHANGE
Target $117
HCWC
Buy
Mirati Therapeutics initial MRTX849 data impressive, says H.C. Wainwright
H.C. Wainwright analyst Edward White says Mirati Therapeutics' (MRTX) initial MRTX849 data are impressive and comparable with Amgen's (AMGN) AMG510's results. The analyst continues to estimate MRTX849 sales of $135.5M in 2023, growing to approximately $1.5B in 2027. He keeps a Buy rating on Mirati Therapeutics with a $117 price target.
10/29/19
COWN
10/29/19
NO CHANGE
COWN
Outperform
Mirati Therapeutics data impressive, says Cowen
Cowen analyst Chris Shibutani called the data release from Mirati Therapeutics, "impressive" citing both the response and safety profile. The analyst said the monotherapy response in CRC is an upside surprise and caused him to raised his DCF to $125 from $120. Shibutani reiterated his Outperform rating on Mirati Therapeutics shares.
11/05/19
GUGG
11/05/19
NO CHANGE
Target $128
GUGG
Buy
Mirati Therapeutics price target raised to $128 from $116 at Guggenheim
Guggenheim analyst Michael Schmidt raised his price target for Mirati Therapeutics to $128 from $116 and keeps a Buy rating on the shares following the company's Q3 results. The company previously presented data on MRTX849, which served as an "incremental de-risking event," Schmidt tells investors in a research note. He believes MRTX849 "now stands in its own right" after prior external validation of anti-G12C mechanism by competitor AMG-510. As such, he increased his probability-of-success assumptions to 70% and 40% in non-small-cell lung carcinoma and colorectal cancer respectively, from 60% and 30% previously. Schmidt keeps a Buy rating on Mirati Therapeutics.

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