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ESPR

Esperion

$41.00

2.25 (5.81%)

11:09
11/12/19
11/12
11:09
11/12/19
11:09

Esperion announces publication of results of Phase 3 study of bempedoic acid

Esperion announce that the results from the 779 patient, 52 week, Phase 3, double-blind, randomized placebo-controlled study of bempedoic acid were published in the Journal of the American Medical Association. Bempedoic acid is being developed as a, convenient, once-daily, oral therapy for the treatment of patients with elevated low-density lipoprotein cholesterol added onto maximally tolerated statin therapy. Bempedoic acid and the bempedoic acid 180 mg + ezetimibe 10 mg fixed dose combination tablets' new drug applications are currently under regulatory review by the U.S. Food and Drug Administration, and the marketing authorisation applications are currently under centralized review by the European Medicines Agency. Study 2 evaluated the long-term safety, tolerability and efficacy, of bempedoic acid 180 mg versus placebo in 779 patients with atherosclerotic cardiovascular disease and/or heterozygous familial hypercholesterolemia inadequately controlled with current lipid-modifying therapies, added-on to maximally tolerated statin therapy, which may mean no statin at all. The JAMA publication includes results from the primary efficacy endpoint of LDL-C lowering at 12-weeks and key secondary endpoints of safety and tolerability over 52-weeks, including that bempedoic acid: significantly lowered LDL-cholesterol by 17 percent on background maximally tolerated statin therapy at 12 weeks, and the effect was durable through 52-weeks; significantly lowered high-sensitivity C-reactive protein, an important marker of the underlying inflammation associated with cardiovascular disease, by 19 percent, and the effect was durable through 52-weeks; reduced hemoglobin A1c by 0.21% vs. placebo in patients with diabetes at 12 weeks, favorable glycemic control and less worsening of diabetes persisted over the 52-week treatment period; showed overall adverse event rates comparable with placebo at 52 weeks, and the proportion of patients with reported serious adverse events was similar compared with placebo at 52 weeks; and showed adjudicated 3-component major adverse cardiac event rates of 2.7% with BA and 4.7% with placebo.

  • 21

    Feb

  • 26

    Feb

ESPR Esperion
$41.00

2.25 (5.81%)

09/16/19
GSCO
09/16/19
UPGRADE
Target $45
GSCO
Neutral
Esperion upgraded to Neutral from Sell at Goldman Sachs
Goldman Sachs analyst Paul Choi upgraded Esperion to Neutral from Sell but lowered his price target on the shares to $45 from $55, stating that he now sees less risk of the launch performance of bempedoic acid disappointing over the intermediate term since 2019-2022 consensus revenue estimates have come down "meaningfully." His product revenue estimates are mostly unchanged, but Choi has increased his launch related cost assumptions and slightly delayed R&D costs related to development of bempedoic acid in diabetics, the analyst noted in explaining his change in price target.
09/16/19
09/16/19
UPGRADE

Fly Intel: Top five analyst upgrades
Catch up on today's top five analyst upgrades with this list compiled by The Fly: 1. Raytheon (RTN) upgraded to Overweight from Neutral at JPMorgan with analyst Seth Seifman saying the stock's outperformance thus far in September is a sign of increasing investor confidence in the outlook for Raytheon and for the United Technologies (UTX) combination, along with some mean reversion. 2. Uber (UBER) and Lyft (LYFT) upgraded to Buy from Hold at HSBC. 3. Schlumberger (SLB) upgraded to Overweight from Equal Weight at Barclays with analyst J. David Anderson saying new CEO Olivier Le Peuch "hit all the right notes" as he repositions the company to succeed in a lower growth environment. 4. RE/MAX Holdings (RMAX) upgraded to Outperform from Market Perform at JMP Securities. 5. Esperion (ESPR) upgraded to Neutral from Sell at Goldman Sachs with analyst Paul Choi saying he now sees less risk of the launch performance of bempedoic acid disappointing over the intermediate term since 2019-2022 consensus revenue estimates have come down "meaningfully." This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.
09/18/19
STFL
09/18/19
NO CHANGE
Target $70
STFL
Buy
Stifel cuts Esperion target to $70, sees entry point after selloff
Stifel analyst Derek Archila lowered his price target for Esperion Therapeutics to $70 from $112 to reflect more conservative assumptions but reiterates a Buy rating on the shares. Even with more conservative forecasts, Esperion is undervalued at these levels, Archila tells investors in a research note. He thinks the stock continues to reflect investor skepticism on the commercial opportunity for bempedoic acid and the company's cash runway. The analyst views bempedoic acid as a "clinically de-risked asset" with two upcoming PDUFA's in February 2020 and believes the cardiovascular outcomes trial design portends a high probability of success. Archila sees a nice entry point into Esperion following the recent selloff and is a buyer of the stock at current levels.
09/26/19
SBSH
09/26/19
NO CHANGE
SBSH
Esperion an attractive buy ahead of bempedoic acid decision, says Citi
Citi analyst Joel Beatty says Esperion Therapeutics remains an attractive stock to own for investors with both short and long investment horizons ahead of the bempedoic acid FDA action dates in February. The analyst has a "high conviction in the approval of bempedoic acid and sees 20% share upside on the news. For investors with longer horizons, Esperion "remains very attractive commercially" at its current $700M enterprise value, contends Beatty. He keeps a Buy rating on the shares with a $73 price target.

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