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SRPT

Sarepta

$101.00

0.99 (0.99%)

08:45
11/14/19
11/14
08:45
11/14/19
08:45

Sarepta announces collaboration, license agreement with StrideBio

arepta Therapeutics announced the signing of a collaboration and license agreement to develop in vivo AAV-based therapies for up to eight central nervous system and neuromuscular targets. Pursuant to the agreement, Sarepta is granted an exclusive license on selected targets to leverage StrideBio's novel, structure-driven capsid technology, intended to enhance specific tropism to tissues of interest and evade neutralizing antibodies. The parties also plan to focus on strategies intended to address re-dosing challenges in patients who have received AAV-delivered gene therapy. StrideBio will conduct all investigational new drug enabling research, development and manufacturing for the first four CNS targets, which are MECP2, SCN1A, UBE3A, and NPC1. Additionally, Sarepta will have an exclusive option to four additional targets based on StrideBio's capsid technology. StrideBio has created a growing portfolio of novel AAV capsids evolved in non-human primates that show reduced seroprevalence and potential for improved tropism to targeted tissues. Under the terms of the agreement, StrideBio will be responsible for AAV capsid development, non-clinical development and manufacturing of preclinical candidates to be selected for advancement into clinical studies. The parties will also share early clinical development activities for selected targets, with Sarepta responsible for late stage development and commercialization. A total of four initial targets are specified under the collaboration. StrideBio will receive a $48M upfront payment in the form of cash and Sarepta stock, in addition to significant future development, regulatory and commercial milestones for the four programs. StrideBio will also receive royalties on worldwide net sales of any commercial products developed through the collaboration. Sarepta has also obtained an exclusive option to expand the collaboration to include up to an additional four targets with an upfront payment of up to $42.5M along with future downstream milestone payments, while StrideBio has an option to obtain co-development and co-commercial rights to one of the collaboration targets. In addition, Sarepta has made a commitment to invest in StrideBio's next financing round. Further financial terms were not disclosed.

SRPT Sarepta
$101.00

0.99 (0.99%)

11/04/19
NOMU
11/04/19
NO CHANGE
Target $230
NOMU
Buy
Sarepta has 'signficant upside catalysts ahead,' says Nomura Instinet
Nomura Instinet analyst Christopher Marai sees "significant upside catalysts ahead into mid-2020" for Sarepta Therapeutics. Ahead of the company's Q3 results on November 7 he keeps a Buy rating on the shares with a $230 price target. The analyst thinks Golodirsen's Complete Response Letter will likely be resolved in the near-term and that Sarepta's "valuation floor" is based on its current exon skipping platform.
11/08/19
PIPR
11/08/19
NO CHANGE
Target $185
PIPR
Overweight
Piper Jaffray 'happy' Sarepta's Q3 came with no surprises
Piper Jaffray analyst Danielle Brill says she's happy that Sarepta Therapeutics' Q3 update came with no surprises. While the analyst was hoping to hear an update on next steps for golodirsen, she points out that management made it clear that they won't comment until there's definitive clarity on the path forward. Brill remains bullish and thinks Sarepta is on track for a "transformational" 2020. She keeps an Overweight rating on the shares with a $185 price target.
11/08/19
FBCO
11/08/19
NO CHANGE
Target $185
FBCO
Outperform
Sarepta price target lowered to $185 from $201 at Credit Suisse
Credit Suisse analyst Martin Auster lowered his price target for Sarepta to $185 from $201, saying the company's earnings call was "fairly benign" with no major pipeline updates. Auster tells investors investors in a research note that he expects that the higher expense burn will continue as the company continues to ramp up manufacturing and transition to building up product inventory.
11/12/19
PIPR
11/12/19
NO CHANGE
Target $185
PIPR
Overweight
Time to dismiss Solid Biosciences as Sarepta competitor, says Piper Jaffray
Piper Jaffray analyst Danielle Brill says that while she had dismissed Solid Biosciences' (SLDB) microdystophin gene therapy program as a competitive threat to Sarepta Therapeutics (SRPT), some investors worried that Solid could provide compelling data after adjusting protocol and moving up the dose. However, today's report of another clinical hold confirms that Solid's construct is toxic, indicating that Pfizer's (PFE) may to too, Brill tells investors in a research note. The analyst points out that both Solid and Pfizer use AAV9 and have had complement mediated serious adverse events after dosing just a few patients. Solid's program reaffirms her view that Sarepta's safety profile is differentiated. It is unlikely that the competition "is viable, let alone will ever catch up," says Brill. She keeps an Overweight rating on Sarepta Therapeutics with a $185 price target. The stock in midday trading is up 4% to $99.02 while Solid Biosciences is down 71% to $3.22.

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LPL

LG Display

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0.115 (1.89%)

20:17
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ETNB

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BPMC

Blueprint Medicines

$78.50

3.92 (5.26%)

20:15
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TLSNY

Telia

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ARWR

Arrowhead

$67.25

1.705 (2.60%)

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ARGX

Argenx

$147.31

-2.56 (-1.71%)

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STC

Stewart

$43.16

0.28 (0.65%)

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First American

$63.05

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PFSI

PennyMac Financial

$33.91

0.12 (0.36%)

19:54
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AGIO

Agios Pharmaceuticals

$40.93

0.81 (2.02%)

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BPMC

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$78.50

3.92 (5.26%)

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FATE

Fate Therapeutics

$13.64

0.07 (0.52%)

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RCKT

Rocket Pharmaceuticals

$22.37

2.61 (13.21%)

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ARGX

Argenx

$147.31

-2.56 (-1.71%)

, JNJ

Johnson & Johnson

$140.36

0.79 (0.57%)

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ARGX

Argenx

$147.31

-2.56 (-1.71%)

JNJ

Johnson & Johnson

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