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IONS

Ionis Pharmaceuticals

$57.61

0.6 (1.05%)

, BIIB

Biogen

$281.71

-9.67 (-3.32%)

09:00
11/14/19
11/14
09:00
11/14/19
09:00

William Blair says Ionis fairly valued on Spinraza headwinds

William Blair analyst Myles Minter initiated coverage of Ionis Pharmaceuticals with a Market Perform rating and $58 fair value estimate. Spinraza, which is marketed by Biogen (BIIB), generates about $2B in revenue per year and has revolutionized the treatment of spinal muscular atrophy, but its long-term growth potential faces headwinds, Minter tells investors in a research note. The analyst anticipates the recent approval of Novartis's (NVS) Zolgensma, an SMA gene therapy, will erode Spinraza's market share of new-start type-1 SMA patients. But more concerning, according to Minter, is the potential 2020 U.S. approval of Roche's (RHHBY) risdiplam, which he believes could erode Spinraza's total market share of type-2/3 patients given a more favorable oral route of delivery. The analyst sees Ionis shares as fairly valued at current levels given the near-term headwinds for its commercial franchise.

IONS

Ionis Pharmaceuticals

$57.61

0.6 (1.05%)

BIIB

Biogen

$281.71

-9.67 (-3.32%)

NVS

Novartis

$89.90

0.615 (0.69%)

RHHBY

Roche

$0.00

(0.00%)

  • 18

    Nov

  • 07

    Dec

IONS Ionis Pharmaceuticals
$57.61

0.6 (1.05%)

11/13/19
BOFA
11/13/19
INITIATION
Target $70
BOFA
Buy
Ionis Pharmaceuticals initiated with a Buy at BofA/Merrill
BofA/Merrill analyst Jason Gerberry initiated coverage of Ionis Pharmaceuticals with a Buy rating and $70 price target. The analyst sees a favorable risk/reward profile ahead of the company's 2020 data catalysts. Further, he believes the rollout of new product driven royalty streams puts Ionis in a strong financial position.
11/07/19
MSCO
11/07/19
DOWNGRADE
Target $48
MSCO
Underweight
Morgan Stanley downgrades Ionis to Underweight ahead of 'challenging' 2020
As previously reported, Morgan Stanley analyst David Lebowitz downgraded Ionis Pharmaceuticals to Underweight from Equal Weight with a price target of $48, down from $63, citing what he sees as a lack of near-term catalysts and what he thinks will be a "challenging" year ahead. While he acknowledges Spinraza remains strong, the company reported weak results from Tegsedi yesterday and Lebowitz doesn't think its pipeline appears ready with a next "break-out therapy" despite having over 40 clinical stage candidates.
11/07/19
MSCO
11/07/19
DOWNGRADE
Target $48
MSCO
Underweight
Ionis downgraded to Underweight from Equal Weight at Morgan Stanley
Morgan Stanley analyst David Lebowitz downgraded Ionis Pharmaceuticals to Underweight from Equal Weight with a $48 price target.
11/14/19
WBLR
11/14/19
INITIATION
WBLR
Market Perform
Ionis Pharmaceuticals initiated with a Market Perform at William Blair
William Blair analyst Myles Minter initiated coverage of Ionis Pharmaceuticals with a Market Perform rating.
BIIB Biogen
$281.71

-9.67 (-3.32%)

11/12/19
RHCO
11/12/19
INITIATION
Target $337
RHCO
Buy
Biogen initiated with a Buy at SunTrust
SunTrust analyst Robyn Karnauskas initiated coverage of Biogen with a Buy rating and $337 price target. The analyst is positive on the company's risk-reward profile of its aducanumab gaining FDA approval, with added near-term value from its Spinraza as doctors and patients take time to gain familiarity, durability, and efficacy of newer drugs. Karnauskas sees further upside for Biogen from its interest in the Chinese market for their biosimilars and its capital allocation strategy with Samsung Bioepis.
11/12/19
11/12/19
INITIATION

Fly Intel: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. Arlo Technologies (ARLO) resumed with a Buy at Deutsche Bank. 2. Clarivate Analytics (CCC) initiated with a Hold at Stifel. 3. Stoke Therapeutics (STOK) initiated with a Buy at BTIG. 4. BioMarin (BMRN), Biogen (BIIB), and Amgen (AMGN) were initiated with a Buy at SunTrust. 5. Corteva (CTVA) initiated with a Buy at Redburn. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.
10/30/19
10/30/19
UPGRADE

Fly Intel: Top five analyst upgrades
Catch up on today's top five analyst upgrades with this list compiled by The Fly: 1. Biogen (BIIB) upgraded to Outperform from Market Perform at Bernstein with analyst Aaron Gal saying that the controversy is solidly around aducanumab. 2. Nu Skin (NUS) upgraded to Hold from Sell at Stifel with analyst Mark Astrachan saying while he thinks trends in China, which makes up 33% of sales, will likely remain negative for the foreseeable future, he now thinks they are unlikely to worsen. 3. Microchip (MCHP) upgraded two notches to Strong Buy from Market Perform at Raymond James while Analog Devices (ADI) was upgraded to Outperform from Market Perform. 4. National Oilwell (NOV) upgraded to Buy from Neutral at Goldman Sachs with analyst Angie Sedita citing the company's revenue growth and cost cutting. 5. AMD (AMD) upgraded to Buy from Hold at Loop Capital and CFRA. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.
11/01/19
STPT
11/01/19
DOWNGRADE
STPT
Hold
Biogen downgraded to Hold from Buy at Standpoint Research
Standpoint Research analyst Ronnie Moas downgraded Biogen to Hold from Buy.
NVS Novartis
$89.90

0.615 (0.69%)

09/13/19
DBAB
09/13/19
NO CHANGE
DBAB
Hold
Novartis' ofatumumab to be 'strong' competitor to Roche drug, says Deutsche Bank
Deutsche Bank analyst Richard Parkes tells investors in a research note after attending the ECTRIMS conference in Stockholm that data from Novartis' (NVS) ASCLEPIOS trials suggests ofatumumab will be a "strong" competitor for Roche's (RHHBY) Ocrevus in relapsing/remitting multiple sclerosis. Parkes says he expects physicians to view the drugs as having broadly comparable and highly compelling efficacy, with ofatumumab's at-home dosing an attractive option for some patients, suggesting meaningful upside potential to his current 2024E ofatumumab sales of $1.1B and possible risks to his forecasts for Roche's Ocrevus. According to physician feedback, Parkes says the drugs are likely to share a rapidly growing market. Parkes maintains a Hold rating and 90 CHF price target on Novartis shares.
10/08/19
PIPR
10/08/19
NO CHANGE
Target $435
PIPR
Overweight
Piper positive on Regeneron after 'significant let-down' Novartis label
Piper Jaffray analyst Christopher Raymond is "incrementally positive" on Regeneron Pharmaceuticals (REGN) after the FDA approved Novartis' (NVS) Beovu for the treatment of wet age-related macular degeneration. While the approval was anticipated and physician anticipation of the drug has been high, doctors are likely to view the drug's label "as a significant let-down," Raymond tells investors in a research note. The analyst says that with inflammation and immunogenicity rates meaningfully higher than Regeneron's Eylea, and the lack of flexibility to dose more frequently, he sees little reason for doctors to switch. And while some investors may point to price as another meaningful lever, off-label Avastin makes for an "insurmountable bar for the price-sensitive segment," says Raymond. He keeps an Overweight rating on Regeneron shares with a $435 price target. The label "renders Beovu as little more than an also-ran," contends the analyst. As such, Raymond thinks Eylea's dominance in remains intact.
10/15/19
BOFA
10/15/19
NO CHANGE
BOFA
Europe 1 List changes at BofA/Merrill
BofA/Merrill added Roche (RHHBY) and Sanofi (SNY) to the Europe 1 List and removed AstraZeneca.
11/12/19
COWN
11/12/19
NO CHANGE
Target $100
COWN
Outperform
Novartis remains a top pharma pick, catalysts cited at Cowen
Cowen analyst Steve Scala said Novartis remains his top pick in pharma for 2019 following strong Q3 results and positive insights into many of its drugs. The analyst said there are many upcoming events through year-end including December's R&D update meeting, EU approvals of Zolgensma and Beovu, and key data readouts. Scala reiterated his Outperform rating and $100 price target on Novartis shares.
RHHBY Roche
$0.00

(0.00%)

10/15/19
CANT
10/15/19
NO CHANGE
Target $65
CANT
Neutral
Cantor keeps Neutral on Ionis after Roche boosts Phase 3 study size
Roche (RHHBY) disclosed yesterday that the size of the RG6042 Phase 3 trial in Huntington's increased from 660 people to 801, Cantor Fitzgerald analyst Eliana Merle tells investors in a research note. Per company comments, this is driven by high patient demand and potential to increase statistical power, particularly for the Q16W dose, adds the analyst. Merle, however, thinks investors might see this change as suggesting the Phase 3 needed more patients for sufficient powering. For her part, the analyst continues to see Huntington's as a challenging indication to study in a clinical trial setting. The higher patient number should improve the likelihood of statistical success, however, says Merle. The analyst, who believes Huntington's is the key stock focus for Ionis Pharmaceuticals investors, keeps a Neutral rating on Ionis shares with a $65 price target.
11/01/19
LEER
11/01/19
NO CHANGE
Target $26
LEER
Outperform
Dicerna price target raised to $26 from $22 at SVB Leerink
SVB Leerink analyst Mani Foroohar raised his price target for Dicerna Pharmaceuticals (DRNA) to $26 from $22 saying the terms for the company's partnership with Roche (RHHBY) to develop and commercialize DCR-HBVS are "quite favorable." Dicerna will receive a $200M upfront payment, up to $1.47B in potential milestones, and up to mid-teens royalties on future sales. The transaction is "meaningfully validating" for Dicerna's strategy for large population indications, Foroohar tells investors in a research note. With shares trading at an implied enterprise value "materially below" the pre-deal value, investors should begin to appreciate the scope of the potential partnership opportunities, says the analyst. He keeps an Outperform rating on Dicerna.
11/01/19
HCWC
11/01/19
NO CHANGE
Target $22
HCWC
Buy
Dicerna HBV deal earlier, on better terms than expected, says H.C. Wainwright
H.C. Wainwright analyst Ed Arce affirmed his Buy rating on Dicerna Pharmaceuticals (DRNA) shares after the companpy announced a collaboration and licensing agreement with Roche (RHHBY) for the worldwide development and commercialization the company's lead asset for the treatment of hepatitis B virus, or HBV. While he has long anticipated "a large HBV deal," the collaboration with Roche is earlier, and with better economics, than Arce had expected, the analyst tells investors. He maintains a $22 price target on Dicerna shares.

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ARWR

Arrowhead

$66.47

-0.91 (-1.35%)

, GVA

Granite Construction

$26.21

-1.335 (-4.85%)

17:27
12/13/19
12/13
17:27
12/13/19
17:27
Hot Stocks
Breaking Hot Stocks news story on Arrowhead, Granite Construction »

Arrowhead to replace…

ARWR

Arrowhead

$66.47

-0.91 (-1.35%)

GVA

Granite Construction

$26.21

-1.335 (-4.85%)

03/08/13
Wedge Partners
03/08/13
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03/06/13
Citigroup
03/06/13
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OAS

Oasis Petroleum

$2.68

-0.295 (-9.93%)

, SWN

Southwestern Energy

$2.00

-0.12 (-5.66%)

17:25
12/13/19
12/13
17:25
12/13/19
17:25
Hot Stocks
Oasis, Southwestern to replace Unit Corp., Frontier in S&P 600 at open on 12/23 »

Oasis Petroleum (OAS) and…

OAS

Oasis Petroleum

$2.68

-0.295 (-9.93%)

SWN

Southwestern Energy

$2.00

-0.12 (-5.66%)

UNT

Unit Corp.

$0.83

-0.0626 (-6.98%)

FTR

Frontier Communications

$0.68

0.0315 (4.84%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
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03/06/13
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  • 23

    Mar

AMRN

Amarin

$24.12

1.12 (4.87%)

17:24
12/13/19
12/13
17:24
12/13/19
17:24
Hot Stocks
Amarin raises guidance after FDA approves Vascepa »

Amarin (AMRN) shares…

03/08/13
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03/06/13
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  • 28

    Dec

LOPE

Grand Canyon

$89.24

-0.86 (-0.95%)

, LEA

Lear

$129.43

-0.84 (-0.64%)

17:22
12/13/19
12/13
17:22
12/13/19
17:22
Hot Stocks
Grand Canyon, Lear to replace Oasis, Southwestern in S&P 400 at open on 12/23 »

Grand Canyon Education…

LOPE

Grand Canyon

$89.24

-0.86 (-0.95%)

LEA

Lear

$129.43

-0.84 (-0.64%)

OAS

Oasis Petroleum

$2.68

-0.295 (-9.93%)

SWN

Southwestern Energy

$2.00

-0.12 (-5.66%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
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  • 23

    Mar

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