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AVEO

Aveo Pharmaceuticals

$0.64

-0.0088 (-1.37%)

06:05
11/18/19
11/18
06:05
11/18/19
06:05

Aveo Pharmaceuticals presents new data from Phase 3 TIVO-3 trial of tivozanib

AVEO Oncology announced the presentation of updated data from the Phase 3 TIVO-3 trial. The data were presented on Saturday, November 16, 2019, at the 18th International Kidney Cancer Symposium in Miami, in an oral presentation titled "TIVO-3: A Phase 3 Study to Compare Tivozanib to Sorafenib in Subjects with Refractory Advanced Renal Cell Carcinoma Overall Survival 2-Year Update" by Sumanta Kumar Pal, M.D., Associate Clinical Professor, Department of Medical Oncology and Therapeutics Research, and Co-director, Kidney Cancer Program, at City of Hope Comprehensive Cancer Center. TIVO-3 is the company's Phase 3 randomized, controlled, multi-center, open-label study to compare tivozanib, the company's vascular endothelial growth factor receptor tyrosine kinase inhibitor, to sorafenib in 350 subjects with highly refractory metastatic RCC. As previously presented, results for the intent to treat population showed that tivozanib significantly improved progression free survival (PFS), the study's primary endpoint, and overall response rate compared to sorafenib, with responses to tivozanib more durable than sorafenib. Newly presented data include the recently announced interim overall survival hazard ratio of 0.99 within the ITT population, as well as results from two prespecified subgroup analyses of patients previously treated with a checkpoint inhibitor and a VEGF-TKI, or two VEGFR-TKIs. Superior PFS and ORR, as well as OS HRs below 1, favoring tivozanib, were observed in the prespecified subgroups. Tivozanib was shown to have lower overall rates of adverse events and fewer dose interruptions and reductions versus sorafenib, indicating better patient tolerability.

AVEO Aveo Pharmaceuticals
$0.64

-0.0088 (-1.37%)

04/04/19
PIPR
04/04/19
NO CHANGE
Target $3
PIPR
Overweight
Piper maintains Overweight rating, $3 target on Aveo after stock sale
Piper Jaffray analyst Edward Tenthoff maintains his Overweight rating and $3 price target on Aveo Pharmaceuticals after the company "opportunistically" raised $25M by issuing 21.7M shares at $1.15 per share and 21.7M in warrants with a $1.25 strike price. The analyst, who estimates that Aveo now holds pro forma cash of about $57M, said the primary driver for the stock remains the OS analysis for TIVO-3 that is scheduled to be reported in Q4. If the hazard ratio does not drop to less than 1.0 for tivozanib, Tenthoff does not believe the FDA will accept a new NDA filing, he noted.
09/10/19
PIPR
09/10/19
NO CHANGE
Target $4
PIPR
Overweight
Aveo Pharmaceuticals price target raised to $4 from $3 at Piper Jaffray
Piper Jaffray analyst Edward Tenthoff raised his price target for Aveo Pharmaceuticals to $4 from $3 after the company announced that tivozanib's overall survival hazard ratio was 0.99 as of a planned analysis on August 15. The analyst continues to anticipate launch in the 3rd and 4th-line renal cell carcinoma setting in 2021. The analyst reduced his tivozanib discount rate and keeps an Overweight rating on shares of Aveo Pharmaceuticals.
09/11/19
HCWC
09/11/19
UPGRADE
Target $1.75
HCWC
Buy
Aveo Pharmaceuticals upgraded to Buy from Neutral at H.C. Wainwright
H.C. Wainwright analyst Swayampakula Ramakanth upgraded Aveo Pharmaceuticals to Buy from Neutral and raised his price target for the shares to $1.75 from $1.00. The company yesterday provided an update from the ongoing Phase 3 Tivo-3 study of tivozanib for the treatment of advanced renal cell carcinoma that showed an improved overall survival hazard ratio of 0.99 compared to 1.12 reported back in February, Ramakanth tells investors in a research note. The analyst is encouraged and believes tivozanib could back on track for U.S. regulatory approval in 2021.
11/04/19
PIPR
11/04/19
NO CHANGE
Target $2
PIPR
Overweight
Aveo price target cut to $2 from $4 at Piper Jaffray
Piper Jaffray analyst Edward Tenthoff backed an Overweight rating on Aveo but lowered its price target on the shares to $2 from $4 after the FDA recommended that the company wait for final TIVO-3 Overall Survival data next June. Tenthoff, who noted that Aveo intends to file an NDA for tivozanib in third and fourth line renal cell carcinoma, said that if the overall survival hazard ratio returns above 1.0, he does not believe the FDA would accept a tivo NDA resubmission. The analyst added that he is pushing out the U.S. third-line+ RCC launch to 2022 and removing first-line RCC sales.

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