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SPRO

Spero Therapeutics

$11.42

0.25 (2.24%)

08:50
11/26/19
11/26
08:50
11/26/19
08:50

Spero Therapeutics expects to report data from Phase 3 trial of SPR994 in 3Q20

Spero Therapeutics announced that it will host a key opinion leader breakfast symposium on the unmet need, treatment landscape and potential for oral SPR994 as a new therapeutic option in complicated urinary tract infections, as well as the opportunity for oral SPR720 in non-tuberculous mycobacterial infections. The event will be held on Thursday, December 5, 2019, from 8:30 a.m. - 10:30 a.m. ET in New York. As part of the event, Yoav Golan, MD, MS, FIDSA, Attending Physician and Associate Professor of Medicine at the Tufts University School of Medicine, will present an overview of the burden of disease in cUTI and the potential for oral SPR994 to change the treatment landscape. If approved, SPR994 has the potential to be the first oral carbapenem antibiotic for use in adults to treat cUTI. A pivotal Phase 3 clinical trial of SPR994 for the treatment of cUTI entitled ADAPT-PO continues to enroll patients, and Spero expects to report top-line data from the Phase 3 clinical trial in the third quarter of 2020. The Company will also present an overview of the progress in the SPR720 program. SPR720 is an orally administered antimicrobial agent being developed for the treatment of a rare, orphan disease, non-tuberculous mycobacterial infections and other infections, including Mycobacterium tuberculosis. SPR720 is currently being evaluated in a double-blind, placebo-controlled Phase 1 clinical trial to assess the safety, tolerability and pharmacokinetics of SPR720 in healthy volunteers. Spero expects to report top-line data from the Phase 1 clinical trial by year-end 2019.

SPRO Spero Therapeutics
$11.42

0.25 (2.24%)

09/09/19
JANY
09/09/19
INITIATION
Target $27
JANY
Buy
Spero Therapeutics initiated with a Buy at Janney Montgomery Scott
Janney Montgomery Scott initiated Spero Therapeutics with a Buy and $27 price target.
10/02/19
OPCO
10/02/19
NO CHANGE
Target $20
OPCO
Outperform
Spero Therapeutics price target lowered to $20 from $30 at Oppenheimer
Oppenheimer analyst Kevin DeGeeter lowered his price target for Spero Therapeutics to $20 from $30 based on removing SPR741 and SPR206 from his revenue model along with more modest commercial assumptions for SPR994. The analyst has an Outperform rating on the shares given potential for SPR994 to generate positive Phase III results and healthy commercial launch based on use as first-in-class oral carbapenem for nonhospital settings.
10/03/19
JANY
10/03/19
NO CHANGE
Target $31
JANY
Buy
Spero price target raised to $31 from $27 at Janney Montgomery Scott
Janney Montgomery Scott analyst Esther Hong raised her fair value estimate on shares of Spero Therapeutics to $31 from $27, citing her view that the company's Phase 3 study of SPR994 has been "meaningfully de-risked" by the lead-in pharmacokinetic data. Hong maintains a Buy rating on the stock.
11/05/19
HCWC
11/05/19
NO CHANGE
Target $35
HCWC
Buy
Spero Therapeutics price target raised to $35 from $28 at H.C. Wainwright
H.C. Wainwright analyst Raghuram Selvaraju raised his price target for Spero Therapeutics to $35 from $28 after the company announced that an independent review committee evaluated pharmacokinetic data following enrollment of the first 70 patients and recommended that Spero continue the trial using the protocoldefined dose without modification. As a result, the analyst increased his SPR994 probability of launch to 85% from the previous 70%. He keeps a Buy rating on Spero Therapeutics.

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