INmune Bio doses first patient in Phase 1b clinical trial of XPro1595
INmune Bio announced the dosing of the first patient in the Phase Ib clinical trial for patients with Alzheimer's disease. The trial is examining the safety and efficacy of INmune Bio's XPro1595, a next-generation anti-inflammatory drug that selectively neutralizes the "bad" inflammation, soluble tumor necrosis factor, which is strongly implicated in Alzheimer's disease. The multi-center, open-label study is currently enrolling up to 18 patients with Alzheimer's disease who express biomarkers of inflammation. The trial is designed to treat patients for twelve weeks to demonstrate safety and reduction in inflammation as proof of biology. The results will help identify the dose of XPro1595 to be used in a larger Phase II disease modification study.