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CRVS

Corvus Pharmaceuticals

$4.26

-0.36 (-7.79%)

09:23
12/07/19
12/07
09:23
12/07/19
09:23

Corvus reports initial results from Phase 1/1b trial of CPI-818

Corvus Pharmaceuticals announced initial results from its Phase 1/1b trial of CPI-818, the company's ITK-inhibitor. The early clinical data from the study demonstrated specific target engagement by CPI-818, the company said. The CPI-818 Phase 1/1b study is currently enrolling patients with several types of advanced, refractory T-cell lymphomas, including peripheral T-cell lymphoma, angioimmunoblastic T-cell lymphoma, cutaneous T-cell lymphoma and other T-cell lymphomas. Seven patients have been enrolled in the first two dose cohorts in the initial phase of the trial, receiving a 100 mg or 200 mg oral dose of CPI-818 two times per day, with no dose limiting toxicities and no grade 3 or 4 adverse events observed. The results from the pharmacokinetic and occupancy studies for the first seven patients have been in-line with expectations. The company anticipates that a dose that achieves maximum target occupancy will be achieved in the next one or two dose cohorts. CPI-818 has been shown to bind covalently to ITK at low nanomolar concentrations without reacting with other kinases, it added.

CRVS Corvus Pharmaceuticals
$4.26

-0.36 (-7.79%)

05/28/19
ROTH
05/28/19
INITIATION
Target $6
ROTH
Buy
Corvus Pharmaceuticals initiated with a Buy at Roth Capital
Roth Capital initiated Corvus Pharmaceuticals initiated with a Buy and $6 price target.
05/28/19
ROTH
05/28/19
INITIATION
Target $6
ROTH
Buy
Roth Capital starts Corvus with Buy rating, $6 price target
Roth Capital analyst Tony Butler initiated coverage of Corvus Pharmaceuticals with a Buy rating and $6 price target. The analyst projects peak risk-adjusted revenues of $482M in non-small-cell lung carcinoma and renal cell carcinoma from Corvus' lead program ciforadenant. Further, expected clinical updates from the CPI-006 and CPI-818 programs during 2019 could result in "significant upside" to estimates, Butler tells investors in a research note. He believes the company has an expanding pipeline with the potential for exploring novel combinations, which he says is where the "clinical paradigm is heading."
09/11/19
MZHO
09/11/19
INITIATION
Target $7
MZHO
Buy
Corvus Pharmaceuticals initiated with a Buy at Mizuho
Mizuho started orvus Pharmaceuticals with a Buy rating and $7 price target.
09/12/19
MZHO
09/12/19
INITIATION
Target $7
MZHO
Buy
Mizuho starts Corvus Pharmaceuticals with Buy rating, $7 price target
Mizuho analyst Mara Goldstein last night initiated coverage of Corvus Pharmaceuticals with a Buy rating and $7 price target. The analyst likes the adenosine-A2AR pathway and believes there is promise in combination therapy. While the shares have struggled due to "underwhelming" ciforadenant monotherapy data, CPI-006 offers an opportunity to reset expectations, Goldstein tells investors in a research note.

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UNIT

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STT

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$9.01

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JBLU

JetBlue

$19.30

0.28 (1.47%)

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ES

Eversource

$87.74

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PLAY

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VWAGY

Volkswagen

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LIZI

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