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FATE

Fate Therapeutics

$13.64

0.07 (0.52%)

09:27
12/07/19
12/07
09:27
12/07/19
09:27

Fate Therapeutics reports initial clinical data for FT516 and FT50

Fate Therapeutics announced initial clinical data for its FT516 and FT500 off-the-shelf, iPSC-derived natural killer cell product candidates. The first FT516 patient enrolled for the treatment of acute myeloid leukemia was refractory to initial 7+3 induction therapy, multiple subsequent re-induction attempts with chemotherapy, and a combination therapy of venetoclax plus decitabine, the company said. Following outpatient lympho-conditioning, the patient received a first cycle of three once-weekly doses of FT516 as a monotherapy and IL-2 cytokine support. A bone marrow biopsy obtained at day 42 following the completion of the first FT516 treatment cycle showed no morphologic evidence of leukemia and evidence of hematopoietic recovery, it said. Concurrently, no circulating leukemia cells were observed in the peripheral blood, and the patient showed neutrophil recovery without growth factor support. In addition, as of a November 28, 2019 data cutoff, 12 patients have been treated with FT500. No DLTs, FT500-related SAEs or FT500-related Grade greater than or equal to 3 AEs, and no incidents of cytokine release syndrome, neurotoxicity, or graft-versus-host disease, have been reported in 12 patients, the company said. All 12 patients completed the first FT500 treatment cycle of three once-weekly doses

  • 07

    Dec

FATE Fate Therapeutics
$13.64

0.07 (0.52%)

11/06/19
WELS
11/06/19
DOWNGRADE
Target $16
WELS
Market Perform
Fate Therapeutics downgraded to Market Perform from Outperform at Wells Fargo
Wells Fargo analyst Jim Birchenough downgraded Fate Therapeutics to Market Perform from Outperform with a $16 price target.
11/06/19
WELS
11/06/19
DOWNGRADE
Target $16
WELS
Market Perform
Wells Fargo downgrades Fate Therapeutics, cuts target to $16 from $24
Wells Fargo analyst Jim Birchenough downgraded Fate Therapeutics to Market Perform from Outperform with a price target of $16, down from $24. Following the company's Q3 update, the analyst believes it development path makes assessment of efficacy more difficult and could extend and complicate timelines to approval. The decision to prioritize combination therapy trials for FT500, FT516 and FT596 before fully assessing monotherapy activity "may take away clearer nearer catalysts and make interpretation of relative benefit more difficult," Birchenough tells investors in a research note. In the near term, he does not expect Fate's monotherapy efforts to yield meaningful efficacy.
11/06/19
MZHO
11/06/19
NO CHANGE
Target $27
MZHO
Buy
Mizuho backs Buy rating on Fate Therapeutics after competitor downgrade
Mizuho analyst Mara Goldstein attributes today's 10% slide in shares of Fate Therapeutics to a competing firm's downgrade of the stock based on their view of the development path for iPSC-derived NK therapies. With FT516 being explored in combination with rituximab and ahead of FT596, Goldstein sees an opportunity for Fate to gain insight into the effects of combination with rituximab and assess this strategy for FT596, the analyst tells investors. She maintains a Buy rating and $27 price target on Fate shares. The Fly notes that Wells Fargo analyst Jim Birchenough downgraded Fate Therapeutics to Market Perform from Outperform this morning with a price target of $16, down from $24.
11/12/19
RHCO
11/12/19
INITIATION
Target $25
RHCO
Buy
Fate Therapeutics initiated with a Buy at SunTrust
SunTrust analyst Robyn Karnauskas initiated coverage of Fate Therapeutics with a Buy rating and $25 price target. The analyst cites investor "excitement" about the potentially "broad applicability" for the company's therapeutics platform in cancer treatment, with more data points set to emerge in 2020.

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