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AUTL

Autolus Therapeutics

$14.60

-0.18 (-1.22%)

19:23
12/07/19
12/07
19:23
12/07/19
19:23

Autolus presents new data on T cell therapies in leukemia, lymphoma

Autolus Therapeutics announced new data highlighting progress on its next-generation programmed T cell therapies to treat patients with acute lymphoblastic leukemia and adults with relapsed/refractory diffuse large B cell lymphoma. Updated results for ALLCAR19, the Phase 1 trial evaluating AUTO1 in adults with recurrent/refractory ALL, were presented by Dr. Claire Roddie. The trial is designed to assess the primary endpoints of safety and feasibility of product generation, as well as other secondary endpoints, including efficacy. The trial enrolled patients with a high tumor burden, who were considered high-risk for experiencing cytokine release syndrome. Product was manufactured for 19 patients; product for 13 of those patients was manufactured using a semi-automated closed process, which will be used for commercial supply. As of the data cut-off date of November 25, 16 patients had received at least one dose of AUTO1. AUTO1 was well tolerated, with no patients experiencing Grade 3 or greater CRS, and 3 of 16 patients, who had high leukemia burden, experiencing Grade 3 neurotoxicity that resolved swiftly with steroids. Of 15 patients evaluable for efficacy, 13 achieved MRD negative CR at 1 month and all patients had ongoing CAR T cell persistence at last follow up. CD19-negative relapse occurred in 22% patients. In the patients dosed with AUTO1 manufactured in the closed process, 9 of 9 achieved MRD negative CR at 1 month and 6 months event free survival, and overall survival in this cohort was 100%.

  • 07

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    Dec

AUTL Autolus Therapeutics
$14.60

-0.18 (-1.22%)

09/12/19
HCWC
09/12/19
NO CHANGE
Target $24
HCWC
Buy
Autolus' Woodford overhang in the rearview, says H.C. Wainwright
A filing on September 9 places the Woodford Patient Capital Trust Plc ownership of Autolus Therapeutics at 4.7%, down from about 24%, which should put a near-term floor on the stock, H.C. Wainwright analyst Debjit Chattopadhyay tells investors in a research note. The suspension of redemption from Woodford's flagship equity fund had been a principal contributor to the drawdown in Autolus shares during Q2, says the analyst. However, with the overhang now in the review, investors can revisit the company's pipeline, contends Chattopadhyay. The analyst has a Buy rating on the shares with a $24 price target.
09/23/19
NEED
09/23/19
INITIATION
NEED
Buy
Autolus Therapeutics initiated with a Buy at Needham
09/23/19
NEED
09/23/19
INITIATION
Target $26
NEED
Buy
Autolus Therapeutics initiated with a Buy at Needham
Needham analyst Chad Messer initiated Autolus Therapeutics with a Buy rating and a price target of $26, saying the stock may prove to be one of the "most valuable pure play CAR-T investments" available. The analyst cites the company's efforts in developing solutions for CAR-T challenges, which include reducing toxicity, improving T-cell persistence, overcoming resistance, finding new tumor antigen targets, and achieving efficacy in solid tumors. Messer expects Autolus' upcoming data updates - starting with December at ASH - to provide upside for the stock.

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