Breaking News Instant updates and real-time market news.

BPMC

Blueprint Medicines

$78.50 /

+3.92 (+5.26%)

09:06
12/08/19
12/08
09:06
12/08/19
09:06

Blueprint announces initial data from Phase 2 Pioneer trial in mastocytosis

Blueprint Medicines announced initial data from the Phase 2 Pioneer clinical trial of avapritinib in patients with indolent systemic mastocytosis. Initial data from the dose-finding Part 1 of trial showed "rapid and robust reductions" in serum tryptase, a measure of mast cell burden, in patients treated with 25 mg, 50 mg or 100 mg of avapritinib once daily, the company said. All dose levels of avapritinib tested were well-tolerated, and no patients discontinued treatment due to an adverse event, it added.. The results will be presented today in a poster presentation at the American Society of Hematology Annual Meeting. At baseline, all patients had symptomatic disease despite best available therapy. Median Indolent SM Symptom Assessment Form total symptom score was 52. Patients were taking a median of three medications to treat their disease. Mean serum tryptase was 84 micrograms per liter. Across all avapritinib dose cohorts, reductions in serum tryptase were robust, occurred rapidly and were sustained in patients treated up to 30 weeks. The placebo cohort showed no change in serum tryptase at 12 weeks. All doses of avapritinib tested were well-tolerated, and most reported AEs were Grade 1 or 2, according to Blueprint. Across all avapritinib cohorts, five patients had Grade 3 AEs, and no patients had serious AEs. In patients treated with placebo, two patients had Grade 3 AEs, and two patients had serious AEs. There was one Grade 3 cognitive effect reported in the 100 mg cohort. The event resolved following dose modification, and the patient remained on therapy as of the data cutoff date. No patients discontinued treatment due to an AE. Blueprint plans to submit a new drug application to the FDA for avapritinib for the treatment of patients with advanced SM in Q1 of 2020.

  • 08

    Dec

BPMC Blueprint Medicines
$78.50 /

+3.92 (+5.26%)

11/06/19 RAJA
Blueprint Medicines upgraded to Strong Buy from Outperform at Raymond James
11/06/19 RAJA
Blueprint Medicines upgraded to Strong Buy at Raymond James
11/06/19
Fly Intel: Top five analyst upgrades
12/02/19 DBAB
Deutsche Bank initiates Sell Catalyst Call on Blueprint Medicines ahead of data

TODAY'S FREE FLY STORIES

Initiation
Inspire Medical initiated with an Underperform at Oppenheimer » 20:25
01/27/20
01/27
20:25
01/27/20
20:25
INSP

Inspire Medical

$78.50 /

-2.22 (-2.75%)

Oppenheimer analyst Suraj…

Story temporarily locked.
To read stories as they happen please subscribe, Login above, or return tomorrow

Get Free Trial

ShowHide Related Items >><<
03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

Earnings
Notable companies reporting before tomorrow's open » 20:25
01/27/20
01/27
20:25
01/27/20
20:25
PFE

Pfizer

$40.16 /

+0.34 (+0.85%)

, UTX

United Technologies

$151.12 /

-2.05 (-1.34%)

, LMT

Lockheed Martin

$432.31 /

-0.31 (-0.07%)

, MMM

3M

$175.70 /

-2.48 (-1.39%)

, HCA

HCA Healthcare

$141.57 /

-1.88 (-1.31%)

, PCAR

Paccar

$75.15 /

-1.64 (-2.14%)

, MKC

McCormick

$172.74 /

+0.005 (+0.00%)

, NUE

Nucor

$49.21 /

-1.13 (-2.24%)

, PHM

PulteGroup

$44.34 /

+0.62 (+1.42%)

, LEA

Lear

$130.47 /

-3.235 (-2.42%)

, AOS

A.O. Smith

$43.82 /

-1.63 (-3.59%)

, HOG

Harley-Davidson

$34.86 /

-0.37 (-1.05%)

, GPK

Graphic Packaging

$16.42 /

-0.01 (-0.06%)

, CIT

CIT Group

$45.02 /

-0.975 (-2.12%)

Notable companies…

Notable companies reporting before tomorrow's open, with earnings consensus, include Pfizer Inc. (PFE), consensus 57C... United Technologies (UTX), consensus $1.84... Lockheed Martin (LMT), consensus $5.02... 3M (MMM), consensus $2.10... HCA Healthcare (HCA), consensus $3.09... PACCAR (PCAR), consensus $1.51... McCormick (MKC), consensus $1.61... Nucor (NUE), consensus 31C... PulteGroup (PHM), consensus $1.09... Lear Corp. (LEA), consensus $2.20... A. O. Smith (AOS), consensus 59C... Harley-Davidson (HOG), consensus 9C... Graphic Packaging (GPK), consensus 23C... CIT Group (CIT), consensus $1.11.

ShowHide Related Items >><<
03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

Upgrade
Garmin upgraded to Neutral from Underperform at Credit Suisse » 20:15
01/27/20
01/27
20:15
01/27/20
20:15
GRMN

Garmin

$98.40 /

-1.17 (-1.18%)

Credit Suisse analyst…

Story temporarily locked.
To read stories as they happen please subscribe, Login above, or return in 9 minutes

Get Free Trial

ShowHide Related Items >><<
03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

Hot Stocks
SPDR Gold Shares holdings fall to 899.41MT from 900.58MT » 20:06
01/27/20
01/27
20:06
01/27/20
20:06
GLD

SPDR Gold Shares

$149.01 /

+1.05 (+0.71%)

This is the first decline…

Story temporarily locked.
To read stories as they happen please subscribe, Login above, or return tomorrow

Get Free Trial

Hot Stocks
Embraer, Boeing get approval for partnership from Brazil's CADE » 19:24
01/27/20
01/27
19:24
01/27/20
19:24
BA

Boeing

$316.61 /

-6.43 (-1.99%)

, ERJ

Embraer

$17.35 /

-0.485 (-2.72%)

Boeing (BA) and Embraer…

Story temporarily locked.
To read stories as they happen please subscribe, Login above, or return in 9 minutes

Get Free Trial

ShowHide Related Items >><<
03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

Hot Stocks
Fly Intel: After Hours Movers » 18:57
01/27/20
01/27
18:57
01/27/20
18:57
GGG

Graco

$51.41 /

-0.605 (-1.16%)

, BRO

Brown & Brown

$41.70 /

-0.145 (-0.35%)

, IPAR

Inter Parfums

$70.67 /

-1.33 (-1.85%)

, XLRN

Acceleron

$52.83 /

+0.81 (+1.56%)

, SURF

Surface Oncology

$2.93 /

-0.13 (-4.25%)

, MNOV

MediciNova

$6.10 /

-0.26 (-4.09%)

, LAUR

Laureate Education

$17.70 /

+0.04 (+0.23%)

, FFIV

F5 Networks

$132.71 /

-3.14 (-2.31%)

, RMBS

Rambus

$14.57 /

-0.38 (-2.54%)

, JNPR

Juniper

$24.46 /

-0.12 (-0.49%)

, PKI

PerkinElmer

$98.74 /

-1.075 (-1.08%)

, JJSF

J & J Snack Foods

$184.54 /

-2.31 (-1.24%)

, ALEC

Alector

$25.72 /

+1.17 (+4.77%)

, DNLI

Denali Therapeutics

$27.97 /

+3.29 (+13.33%)

UP AFTER EARNINGS: Graco…

UP AFTER EARNINGS: Graco (GGG) up 4.6%... Brown&Brown (BRO) up 2.0%... Inter Parfums (IPAR) up 1.0%. ALSO HIGHER: Acceleron Pharma (XLRN) up 66.1% after announcing its sotatercept trial met endpoints... Surface Oncology (SURF) up 13.8% after getting FDA clearance for SRF617, SRF388 INDs... MediciNova (MNOV) up 11.3% after getting notice of intention to grant patent for MN-001 in Europe... Laureate Education (LAUR) up 4.5% after announcing plans to explore strategic alternatives. DOWN AFTER EARNINGS: F5 Networks (FFIV) down 4.5%... Rambus (RMBS) down 3.2%... Juniper (JNPR) down 2.9%... PerkinElmer (PKI) down 2.7%... J&J Snack Foods (JJSF) down 2.0%. ALSO LOWER: Alector (ALEC) down 2.8% after equity offering... Denali Therapeutics (DNLI) down 2.7% after equity offering. Movers as of 18:45ET.

ShowHide Related Items >><<
03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 30
    Jan
  • 29
    Jan
Hot Stocks
Intuit urges holders to reject mini-tender offer by TRC Capital » 18:50
01/27/20
01/27
18:50
01/27/20
18:50
INTU

Intuit

$283.76 /

-4.41 (-1.53%)

Intuit said it has been…

Story temporarily locked.
To read stories as they happen please subscribe, Login above, or return in 9 minutes

Get Free Trial

ShowHide Related Items >><<
03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

Hot Stocks
Ballard Power says now powers fuel cell EVs for 30M kilometers » 18:46
01/27/20
01/27
18:46
01/27/20
18:46
BLDP

Ballard Power

$9.14 /

-0.56 (-5.77%)

Ballard Power Systems…

Story temporarily locked.
To read stories as they happen please subscribe, Login above, or return tomorrow

Get Free Trial

ShowHide Related Items >><<
03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

Hot Stocks
Merit Medical confirms notice of Starboard director nominations » 18:21
01/27/20
01/27
18:21
01/27/20
18:21
MMSI

Merit Medical

$36.05 /

-0.55 (-1.50%)

Merit Medical Systems…

Merit Medical Systems confirmed that it has received notice from Starboard Value LP that it has nominated seven individuals to stand for election as directors at Merit's 2020 Annual Meeting of Shareholders. In its notice to Merit, Starboard indicated that it intends to withdraw four of its seven nominees if there are only three seats on Merit's Board to be filled at the Annual Meeting. The date of the Annual Meeting has not yet been set. Members of Merit's Board and management team recently had an initial discussion with representatives of Starboard, and Merit looks forward to further engagement to better understand Starboard's ideas. Merit values constructive input from all shareholders toward the shared goal of enhancing stakeholder value, the comapny said.

ShowHide Related Items >><<
03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

Hot Stocks
MediciNova gets notice of intention to grant patent for MN-001 from EPO » 18:02
01/27/20
01/27
18:02
01/27/20
18:02
MNOV

MediciNova

$6.10 /

-0.26 (-4.09%)

MediciNov announced that…

Story temporarily locked.
To read stories as they happen please subscribe, Login above, or return tomorrow

Get Free Trial

ShowHide Related Items >><<
03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

Periodicals
JPMorgan to keep 2019 bonuses flat for traders, bankers, Bloomberg reports » 18:01
01/27/20
01/27
18:01
01/27/20
18:01
JPM

JPMorgan

$132.00 /

-1.14 (-0.86%)

JPMorgan is keeping…

JPMorgan is keeping annual bonuses at its corporate and investment bank approximately flat for 2019, Bloomberg's Michelle Davis reports. The company's decision, described by people briefed on the matter, came after the unit notched its best year since at least 2011. Most of the workers were told about their payouts last week, said one of the people. Reference Link

ShowHide Related Items >><<
03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

Periodicals
CBS says All Access achieved record month of sign-ups, TechCrunch says » 17:59
01/27/20
01/27
17:59
01/27/20
17:59
VIAC

ViacomCBS

$35.13 /

-0.65 (-1.82%)

, VIACA

ViacomCBS

$39.51 /

+0.4 (+1.02%)

CBS's streaming…

Story temporarily locked.
To read stories as they happen please subscribe, Login above, or return tomorrow

Get Free Trial

ShowHide Related Items >><<
03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

Hot Stocks
U.S. FDA approves Trijardy XR for adults with type 2 diabetes » 17:38
01/27/20
01/27
17:38
01/27/20
17:38
LLY

Eli Lilly

$138.38 /

-0.71 (-0.51%)

The U.S. FDA has approved…

The U.S. FDA has approved Trijardy XR to lower blood sugar in adults with type 2 diabetes, along with diet and exercise. Trijardy XR provides three type 2 diabetes medicines in one pill, including Jardiance, Tradjenta, and metformin hydrochloride extended release. Trijardy XR is marketed by Boehringer Ingelheim Pharmaceuticals and Eli Lilly and Company.

ShowHide Related Items >><<
03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

Conference/Events
Morgan Stanley China Economist to hold an analyst/industry conference call » 17:37
01/27/20
01/27
17:37
01/27/20
17:37

Chief Economist &…

Story temporarily locked.
To read stories as they happen please subscribe, Login above, or return tomorrow

Get Free Trial

Hot Stocks
Juniper CFO says 'comfortable' with current Street revenue estimate for FY20 » 17:35
01/27/20
01/27
17:35
01/27/20
17:35
JNPR

Juniper

$24.46 /

-0.12 (-0.49%)

Says looking for FY20…

Says looking for FY20 revenue growth of about 1%. Sees FY20 gross margins "flat to slightly up". Comments taken from Q4 earnings conference call Q/A.

ShowHide Related Items >><<
03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

Earnings
Southern Missouri Bancorp reports Q2 EPS 84c, consensus 81c » 17:33
01/27/20
01/27
17:33
01/27/20
17:33
SMBC

Southern Missouri Bancorp

$36.50 /

+0.1 (+0.27%)

Reports Q2 provision for…

Story temporarily locked.
To read stories as they happen please subscribe, Login above, or return tomorrow

Get Free Trial

ShowHide Related Items >><<
Recommendations
Momenta price target raised to $43 from $29 at Stifel » 17:30
01/27/20
01/27
17:30
01/27/20
17:30
MNTA

Momenta

$28.82 /

+0.62 (+2.20%)

Stifel analyst Derek…

Stifel analyst Derek Archila reiterated a Buy rating on Momenta (MNTA) and raised his price target on shares to $43 from $29, as he believes the shares have "more upside from here." The price target raise follows the recent positive update on M254, which the analyst said "could put pressure on the large traditional IVIG manufacturers to strike a partnership with Momenta or, for one to outright acquire the company."

ShowHide Related Items >><<
03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

Hot Stocks
Instructure says 'strongly disagrees' with conclusion reached by ISS » 17:29
01/27/20
01/27
17:29
01/27/20
17:29
INST

Instructure

$47.97 /

+0.135 (+0.28%)

Instructure issued the…

Story temporarily locked.
To read stories as they happen please subscribe, Login above, or return tomorrow

Get Free Trial

ShowHide Related Items >><<
03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

Syndicate
Allegiance Bancshares files $225M mixed securities shelf  17:27
01/27/20
01/27
17:27
01/27/20
17:27
ABTX

Allegiance Bancshares

$36.48 /

-0.3 (-0.82%)

 
ShowHide Related Items >><<
03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

Syndicate
Helius Medical files $100M mixed securities shelf  17:20
01/27/20
01/27
17:20
01/27/20
17:20
HSDT

Helius Medical

$1.21 /

-0.09 (-6.92%)

 
ShowHide Related Items >><<
03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

Hot Stocks
Sinclair, Nexstar agree to settle lawsuit with Tribune Media » 17:08
01/27/20
01/27
17:08
01/27/20
17:08
SBGI

Sinclair Broadcast

$30.65 /

-0.63 (-2.01%)

, NXST

Nexstar

$122.62 /

-2.29 (-1.83%)

, TRCO

Tribune Media

$0.00 /

+ (+0.00%)

According to a regulatory…

According to a regulatory filing, on January 27, 2020, Sinclair Broadcast Group, Inc. (SBGI) and Nexstar Media Group, Inc. (NXST) agreed to settle the outstanding lawsuit between the company and Tribune Media Company (TRCO), which Nexstar acquired in September 2019. The companies will dismiss with prejudice the lawsuit pending in the Delaware Court of Chancery, between the company and Tribune concerning the terminated Company/Tribune merger, which lawsuit is captioned Tribune Media Company v. Sinclair Broadcast Group, Inc., Case No. 2018-0593-JTL, and will release each other from any current and future claims relating to the terminated merger. Neither party has admitted any liability or wrongdoing in connection with the terminated merger; both parties have settled the lawsuit to avoid the costs, distraction, and uncertainties of continued litigation. As part of the resolution, the company has agreed to sell to Nexstar WDKY-TV in the Lexington, KY Designated Market Area, subject to the approval of the Federal Communications Commission. The company has also sold certain non-license assets associated with KGBT-TV in the Harlingen, Texas DMA, although the company will continue to operate KGBT-TV as an independent television broadcast station. The company and Nexstar have also modified an existing agreement regarding carriage of certain of the company's digital networks by stations acquired by Nexstar in connection with the Tribune acquisition. Finally, the company will make a cash payment of approximately $60M to Nexstar, net of the asset sales purchase price. The company has adequately reserved for this settlement in 2019.

ShowHide Related Items >><<
03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

Hot Stocks
German American Bancorp approves 1M share repurchase plan, 12% dividend increase » 17:06
01/27/20
01/27
17:06
01/27/20
17:06
GABC

German American Bancorp

$34.94 /

-0.12 (-0.34%)

German American Bancorp…

German American Bancorp announced that its board has approved a new share repurchase plan authorizing the repurchase of up to 1M shares, or approximately 4% of the company's total common shares outstanding. Stock repurchases are expected to be made from time to time on the open market or in privately negotiated transactions, subject to applicable securities law. The plan does not obligate the company to repurchase any specific dollar amount or number of shares. The company also announced a 12% increase in its regular quarterly cash dividend, as its board declared a regular quarterly cash dividend of 19c per share, which will be payable on February 20 to shareholders of record as of February 10.

ShowHide Related Items >><<
03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

Hot Stocks
Bladex CEO Gabriel Tolchinsky to step down » 17:06
01/27/20
01/27
17:06
01/27/20
17:06
BLX

Bladex

$21.46 /

-0.4 (-1.83%)

The board of Banco…

Story temporarily locked.
To read stories as they happen please subscribe, Login above, or return tomorrow

Get Free Trial

Earnings
German American Bancorp reports Q4 EPS 59c, consensus 58c » 17:04
01/27/20
01/27
17:04
01/27/20
17:04
GABC

German American Bancorp

$34.94 /

-0.12 (-0.34%)

Reports Q4 tangible book…

Reports Q4 tangible book value per share $16.49. Reports Q4 net charge-offs .15%. Mark Schroeder, German American's chairman & CEO, stated, "2019 saw the continuation of our ongoing efforts to build upon our historic levels of growth and profitability and the enhancement of long-term shareholder value. In particular, we saw continued strong organic growth during this past year within our markets in Southeast Indiana, following the acquisition of River Valley Bancorp in 2016, which opened for us the vibrant markets in the Indiana portion of the Louisville, Kentucky MSA, and the 2018 acquisition of a five-branch network in the greater Columbus, Indiana market area, which greatly enhanced our market presence in that growing area of the state of Indiana. Additionally, we continued in 2019 our strategic expansion into the Commonwealth of Kentucky with the acquisition in July 2019 of Citizens First Corporation of Bowling Green, Kentucky. The combination of the Citizens First footprint in the greater Bowling Green area with that of First Security, Inc. of Owensboro, Kentucky, which we also acquired in 2018, resulted in German American acquiring approximately $1 billion of banking assets within the Commonwealth. We will continue our focus in 2020 on the integration of these operations, as we position the Company for what we believe will be strong organic growth from the Kentucky market area in the coming years."

ShowHide Related Items >><<
03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

Earnings
Ashland reports preliminary Q1 EPS 13c, consensus 7c » 17:04
01/27/20
01/27
17:04
01/27/20
17:04
ASH

Ashland

$75.65 /

+0.315 (+0.42%)

Reports preliminary Q1…

Story temporarily locked.
To read stories as they happen please subscribe, Login above, or return tomorrow

Get Free Trial

ShowHide Related Items >><<
03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

Get Full Fly Access

Breaking market intelligence sent straight to you
Our team of experts analyze every news story and filter out the noise to deliver real-time market moving news.
Up-to-date information on important industry events
Get real-time updates on events that are moving the market—from conferences and calls to syndicate announcements.
News focused on the companies in your portfolio
Create up to 12 portfolios with 150 stocks each, and see how active they are in market news.