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KURA

Kura Oncology

$15.67 /

+0.48 (+3.16%)

12:27
12/08/19
12/08
12:27
12/08/19
12:27

Kura Oncology announces updates for lead drug candidate tipifarnib

Kura Oncology announced clinical and regulatory updates for its lead drug candidate, tipifarnib, in angioimmunoblastic T-cell lymphoma, including data from the Company's ongoing Phase 2 clinical trial of tipifarnib in relapsed or refractory peripheral T-cell lymphoma. The updated interim data are being presented during an oral session today at the American Society of Hematology Annual meeting. As of the November 11 data cutoff date, a total of 26 patients with relapsed or refractory AITL were enrolled in all stages of the trial. Among the 20 patients evaluable for efficacy, five achieved a complete response and five achieved a partial response, for an objective response rate of 50% on an evaluable basis and 38% on an intent-to-treat basis. In addition, three patients experienced disease stabilization. Patients had a median of three prior regimens. Next-generation sequencing of 19 available patient biopsies showed that 10 carried C336R/Q386E variants in the killer-cell immunoglobulin-like receptor 3DL2, an immune checkpoint receptor. Four of the 10 patients with KIR3DL2 variants achieved a CR and three achieved a PR, for a CR rate of 40% and an ORR of 70%. This compares to a CR rate of 11% and an ORR of 22% among the nine AITL patients with KIR3DL2 wild type. Tipifarnib was generally well-tolerated in this Phase 2 trial, with adverse events consistent with its known safety profile, Kura said. "We are encouraged by our growing body of data for tipifarnib in AITL," said Antonio Gualberto, Head of Development and Chief Medical Officer of Kura Oncology. "We believe these data support our efforts to expand the development of tipifarnib beyond our initial focus in HRAS mutant solid tumors and could enable registrational strategies in multiple CXCL12-dependent hematologic and solid tumor indications."

  • 08

    Dec

KURA Kura Oncology
$15.67 /

+0.48 (+3.16%)

07/18/19 DBAB
Kura Oncology initiated with a Buy at Deutsche Bank
09/05/19 JMPS
Kura Oncology resumed with an Outperform at JMP Securities
10/29/19 PIPR
Kura pivotal trial 'highly likely to succeed,' says Piper Jaffray
11/07/19 WEDB
Wedbush still views Kura Oncology as a top pick

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Earnings
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CR

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Reports Q4 revenue $838M,…

Reports Q4 revenue $838M, consensus $824.22M. "We finished 2019 strong, with solid operational performance across our businesses, and we took several other actions to further strengthen Crane for continued profitable growth," said Max Mitchell, Crane Co. President and Chief Executive Officer. "In addition to solid progress on numerous growth and productivity initiatives last year, we delivered a record $325 million of free cash flow. We also repurchased $80 million of shares during the fourth quarter, and today, we raised our dividend by 10%, further reflecting confidence in our long-term outlook."

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The dividend is payable on March 11 to shareholders of record as of the close of business on February 28. The indicated annual dividend rate will now be $1.72 per share.

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