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BGNE

BeiGene

$186.89

-2.3 (-1.22%)

17:50
12/08/19
12/08
17:50
12/08/19
17:50

BeiGene announces data from two clinical trials of Brukinsa at ASH meeting

BeiGene announced clinical data from three trials of its BTK inhibitor Brukinsa were presented at the 61st American Society of Hematology Annual Meeting. In two oral presentations of Brukinsa in patients with chronic lymphocytic leukemia or small lymphocytic lymphoma, the drug candidate demonstrated consistent safety and a high overall response rate; in the poster presentation of Brukinsa combined with BeiGene's investigational anti-PD-1 antibody tislelizumab in patients with previously treated B-cell malignancies, the combination treatment showed preliminary efficacy and was generally well tolerated. "The results presented today on Brukinsa, a BTK inhibitor designed to maximize target occupancy and minimize off-target binding, demonstrated robust clinical activity and a safety profile consistent with what we've observed to date in our clinical trials, including safety data that supported the recent U.S. FDA accelerated approval in patients with previously treated mantle cell lymphoma," said Jane Huang, M.D., Chief Medical Officer, hematology at BeiGene. "CLL or SLL is the most common type of leukemia in adults, and despite the advancements of BTK inhibitor therapy for these cancers, there remains a need for highly selective BTK inhibitors capable of promoting long-term responses, and with a safety profile that is tolerable over time. The results presented here today further demonstrate the potential for Brukinsa to help people living with these persistent, life-threatening cancers."

  • 09

    Dec

  • 27

    Feb

BGNE BeiGene
$186.89

-2.3 (-1.22%)

11/20/19
GUGG
11/20/19
INITIATION
Target $48
GUGG
Buy
Guggenheim starts Zymeworks at Buy with $48 price target
As previously reported, Guggenheim analyst Etzer Darout initiated coverage of Zymeworks (ZYME) with a Buy rating and $48 price target. The company's lead asset, ZW25, is planned for registrational studies in second-line biliary tract cancer and gastroesophageal cancers in 2020 in partnership with BeiGene (BGNE). Additionally, preclinical studies of ZW49 have demonstrated the potential for a differentiated profile relative to current HER-2 targeting ADC's, said Darout, who sees a number of opportunities for "significant share appreciation" from clinical updates of ZW25 and ZW49 over the next 12-18 months.
11/19/19
UBSW
11/19/19
DOWNGRADE
UBSW
Neutral
BeiGene downgraded to Neutral from Buy at UBS
UBS downgraded BeiGene to Neutral from Buy.
11/15/19
GUGG
11/15/19
NO CHANGE
Target $228
GUGG
Buy
BeiGene price target raised to $228 from $205 at Guggenheim
Guggenheim analyst Michael Schmidt raised his price target for BeiGene (BGNE) to $228 from $205 saying FDA approval of Brukinsa over three months ahead of the action date provides additional validation of the company's strategy and ability to execute. He thinks Brukinsa's label in mantle cell lymphoma indicates a "potentially best-in-class" product profile with "nuanced differences" compared to AstraZeneca's (AZN) Calquence and "significantly better" than AbbVie's (ABBV) Imbruvica. The analyst maintains a Buy rating on BeiGene shares.
11/15/19
PIPR
11/15/19
NO CHANGE
Target $230
PIPR
Overweight
BeiGene price target raised to $230 from $200 at Piper Jaffray
Piper Jaffray analyst Tyler Van Buren raised his price target for BeiGene to $230 from $200 following the earlier than expected Brukinsa approval. The analyst accelerated the Brukinsa launch by a quarter with it expected to occur in the coming weeks. He views the label as clean in terms of safety and consistent with the clinical data that has been reported. The "incredibly fast" approval is an indication that the FDA considers BeiGene's global clinical program to be of high quality, Van Buren tells investors in a research note. He believes mantle cell lymphoma represents a ~$1B U.S. opportunity and reiterates an Overweight rating on BeiGene shares.

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MYO

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APLS

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