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MGTA

Magenta Therapeutics

$13.29

0.3 (2.31%)

08:06
12/09/19
12/09
08:06
12/09/19
08:06

Magenta demonstrates gene therapy transplant without chemotherapy in primates

Magenta Therapeutics announced that new results from its CD117-ADC patient preparation program were presented at the 61st Annual Meeting of the American Society of Hematology. These results, which were highlighted in an oral presentation at ASH by John Tisdale, M.D., Director, Molecular and Clinical Hematology Section, National Institutes of Health, showed the first-ever successful transplant of gene-modified cells in non-human primates using a targeted, single-agent antibody-drug conjugate, without the use of chemotherapy or radiation. Results presented by Dr. Tisdale showed: A single dose of a tool CD117-ADC fully depleted human hematopoietic stem cells in humanized mouse models. A single dose of CD117-ADC selectively depleted hematopoietic stem cells in non-human primates, while sparing immune cells, which are important for recovery following transplant. CD117-ADC was engineered to have a fast half-life to clear the body quickly and enabled transplant of the gene-modified cells within days of dosing in non-human primates. A single dose of CD117-ADC in non-human primates enabled successful transplant and engraftment of hematopoietic stem cells modified with a lentiviral vector encoding the beta-globin gene, the gene that causes sickle cell disease and beta-thalassemia. Vector copy number was stable beyond three months, the longest time point in the study, suggesting that the gene-modified cells persisted in the body. This was comparable to historical data with multiple doses of busulfan conditioning. CD117-ADC was well tolerated in non-human primates with no evidence of the often severe side effects seen with busulfan conditioning, including veno-occlusive disease, weight loss, diarrhea, mucositis, vomiting, pulmonary fibrosis or seizures. No ADC-related blood chemistry changes outside normal range were observed. These proof-of-concept studies validate the use of CD117-ADC for targeted stem cell depletion prior to transplant and support its use as a new conditioning agent for gene therapy and stem cell transplant without toxic chemotherapy or radiation.

MGTA Magenta Therapeutics
$13.29

0.3 (2.31%)

03/24/19
GSCO
03/24/19
DOWNGRADE
GSCO
Neutral
Magenta Therapeutics downgraded to Neutral from Buy at Goldman Sachs
Goldman Sachs downgraded Magenta Therapeutics to Neutral on valuation.
03/25/19
GSCO
03/25/19
DOWNGRADE
Target $16
GSCO
Neutral
Magenta Therapeutics downgraded to Neutral on valuation at Goldman Sachs
Goldman Sachs analyst Terence Flynn last night downgraded Magenta Therapeutics to Neutral from Buy and lowered his price target for the shares to $16 from $17. The analyst reduced his near-term estimates for MGTA-456 after the company elected to delay initiation of a Phase 2 trial in sickle cell disease. He cites valuation for the downgrade to Neutral with the shares slightly above his new price target.
12/06/19
GSCO
12/06/19
INITIATION
Target $18
GSCO
Neutral
Magenta Therapeutics assumed with a Neutral at Goldman Sachs
Goldman Sachs analyst Paul Choi assumed coverage of Magenta Therapeutics with a Neutral rating with a price target of $18, up from $16. . While encouraged by Magenta's focus on different stages in the transplant process and the curative potential of transplant, the analyst awaits further clinical validation given the mostly early stage nature of its assets.
12/06/19
BTIG
12/06/19
INITIATION
Target $20
BTIG
Buy
Magenta Therapeutics initiated with a Buy at BTIG
BTIG analyst Amanda Murphy initiated coverage of Magenta Therapeutics with a Buy rating and $20 price target. The analyst notes that the company is developing a suite of therapeutic candidates targeting an improved bone marrow transplant process to address key barriers to adoption. Murphy adds that despite the improvement in technology and the growth in bone marrow transplants, about 60% of 150K heme cancer instances eligible for transplant do not receive one.

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