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PTLA

Portola Pharmaceuticals

$28.48

-0.74 (-2.53%)

15:24
12/09/19
12/09
15:24
12/09/19
15:24

Portola presents new interim Phase 2a data from study of cerdulatinib

Portola Pharmaceuticals announced new interim results from the Company's ongoing Phase 2a study of cerdulatinib, an investigational, oral SYK/JAK inhibitor, in patients with relapsed/refractory follicular lymphoma receiving cerdulatinib alone or in combination with rituximab. The data will be presented today during a poster session at the 61st American Society of Hematology Annual Meeting in Orlando. Data included safety and efficacy findings as of November 2019 for 42 patients who received single agent cerdulatinib at 30 mg twice daily and 21 patients who received cerdulatinib at 30 mg twice daily in combination with a standard dosing regimen of rituximab. The number of prior treatment regimens including anti-CD20 antibody, bendamustine and other alkylating agents, and PI3K inhibitors ranged from one to 10, with a median of three. Among the 42 patients in the cerdulatinib-only cohort, the overall response rate (ORR) was 48%; 7 patients achieved a complete response, 13 patients achieved a partial response and 10 patients achieved stable disease. To date, 16 of the 42 patients in the cerdulatinib-only cohort have been on study drug for at least 10 months. Among the 21 patients evaluated for efficacy in the cerdulatinib and rituximab combination cohort, the ORR was 76%; 5 patients achieved a CR, 11 patients achieved a PR and 5 patients achieved SD. Of the 11 patients in this combination cohort who have been on one to three prior therapies, the ORR was 91% with a complete response rate of 36%. Cerdulatinib was generally well-tolerated and the safety profile appeared similar in both the cerdulatinib-only and rituximab combination cohorts. The most common adverse events occurring in greater than or equal to5% of all evaluable study patients were lipase increase, neutropenia, diarrhea and amylase increase. The most common AEs in the combination cohort included lipase increase, neutropenia and diarrhea. The lipase and amylase changes were generally asymptomatic and not associated with pancreatitis. Additionally, there was no emergence of late-stage colitis, cardiac or liver abnormalities, or other evidence of cumulative toxicity.

PTLA Portola Pharmaceuticals
$28.48

-0.74 (-2.53%)

08/05/19
FBCO
08/05/19
INITIATION
Target $35
FBCO
Neutral
Portola Pharmaceuticals assumed with a Neutral at Credit Suisse
Credit Suisse analyst Tiago Fauth assumed coverage of Portola Pharmaceuticals with a Neutral rating and $35 price target.
08/05/19
08/05/19
INITIATION

Fly Intel: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. Alphatec (ATEC) initiated with an Overweight at Piper Jaffray. 2. So-Young (SY) initiated with a Buy at CLSA. 3. MediWound (MDWD) initiated with a Buy at H.C. Wainwright. 4. Portola Pharmaceuticals (PTLA) assumed with a Neutral at Credit Suisse. 5. Vereit (VER) initiated with an Equal Weight at Morgan Stanley. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.
08/08/19
SBSH
08/08/19
NO CHANGE
Target $51
SBSH
Buy
The time to buy Portola Pharmaceuticals is now, says Citi
In a post-earnings research note titled "The Time to Buy is Now," Citi analyst Yigal Nochomovitz raised his price target for Portola Pharmaceuticals to $51 from $50 and keeps a Buy rating on the shares. The analyst continues to believe Andexxa can be a ~$250M product in 2020 and ~$550M by 2022. Getting to half a billion in sales would require one use per month per hospital, assuming "only" ~1500 active hospitals, which is "very achievable," Nochomovitz tells investors in a research note. This means Portola's fair value is ~$50 per share, not the market view of $27 per share, says the analyst.
11/08/19
GSCO
11/08/19
INITIATION
Target $135
GSCO
Neutral
Portola Pharmaceuticals initiated with a Neutral at Goldman Sachs
Goldman Sachs analyst Graig Suvannavejh initiated coverage of Portola Pharmaceuticals with a Neutral rating and $135 price target. The analyst views the shares as fairy valued as "Andexxa launch execution holds the key."

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