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GTHX

G1 Therapeutics

$23.06

-0.18 (-0.77%)

18:05
12/11/19
12/11
18:05
12/11/19
18:05

G1 Therapeutics presents data from Phase 1b/2a trial of lerociclib at SABCS

G1 Therapeutics reported additional data from the Phase 1b/2a clinical trial investigating its oral CDK4/6 inhibitor lerociclib in combination with fulvestrant for the treatment of estrogen receptor-positive, HER2-negative breast cancer. Updated findings presented during a poster session at the 2019 San Antonio Breast Cancer Symposium, or SABCS, showed lerociclib, dosed without a drug holiday, has a differentiated safety and tolerability profile than observed in clinical trials with currently marketed CDK4/6 inhibitors. Preliminary efficacy findings were consistent with other CDK4/6 inhibitors used in combination with fulvestrant. The Phase 1b/2a trial is designed to evaluate the safety, tolerability and efficacy of lerociclib administered continuously in combination with fulvestrant as a treatment for ER+, HER2- breast cancer and identify the dose and schedule for future trials of lerociclib. Further investigation is ongoing, with longer-duration efficacy data required to determine the dose for future study in a Phase 3 clinical trial. The company expects to share an update in 2020.

GTHX G1 Therapeutics
$23.06

-0.18 (-0.77%)

02/07/19
RILY
02/07/19
INITIATION
Target $55
RILY
Buy
G1 Therapeutics initiated with a Buy at B. Riley FBR
B. Riley FBR analyst Harshita Polishetty started G1 Therapeutics with a Buy rating and $55 price target.
02/07/19
RILY
02/07/19
INITIATION
Target $55
RILY
Buy
B. Riley FBR starts G1 Therapeutics with Buy rating, $55 price target
B. Riley FBR analyst Harshita Polishetty initiated coverage of G1 Therapeutics with a Buy rating and $55 price target. G1's lead candidate, trilaciclib, has the potential to address myelotoxicity and improve overall survival in chemotherapy-associated treatment regimens, Polishetty tells investors in a research note. Further, Lerociclib, although fourth to market, demonstrates potential to be best in class given its clean safety profile thus far adds the analyst. She also believes G1T48 allows for competitive pricing when both lerociclib and G1T48 hit the market.
06/18/19
HCWC
06/18/19
NO CHANGE
HCWC
G1 Therapeutics trial results 'important,' says H.C. Wainwright
H.C. Wainwright analyst Edward White maintained a Buy rating and $71 price target on G1 Therapeutics. The analyst noted that G1 Therapeutics' topline OS improvements from its randomized, open-label Phase 2 trial evaluating trilaciclib in metastatic triple-negative breast cancer were "statistically significant in both treatment arms compared with the control arm." White believes that "an OS benefit seen in a small three-arm trial like this is an important result" and added that "the company can now pursue an efficacy benefit as well as the myelopreservation pathway... for commercialization."
08/08/19
JPMS
08/08/19
UPGRADE
Target $45
JPMS
Overweight
G1 Therapeutics upgraded to Overweight from Neutral at JPMorgan
JPMorgan analyst Anupam Rama upgraded G1 Therapeutics to Overweight from Neutral and raised his price target for the shares to $45 from $38. The analyst sees a "string of important key catalysts" in the second half of 2019 and first half of 2020 for G1's pipeline. Rama now includes G1T48 in his model with initial phase 1 data in ER+/HER2- breast cancer coming at the end of September. Further, at current share levels, the analyst believes limited value is being ascribed to lerociclib.

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