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ACRS

Aclaris Therapeutics

$1.87 /

+ (+0.00%)

16:31
01/09/20
01/09
16:31
01/09/20
16:31

Aclaris Therapeutics aannounces positive results from Phase 1 trial of ATI-450

Aclaris Therapeutics announced positive results from ATI-450-PKPD-101, a Single Ascending Dose and Multiple Ascending Dose Phase 1 clinical trial of the investigational compound ATI-450. Preliminary data demonstrated that ATI-450 resulted in marked inhibition of TNFalpha, IL1beta, IL8, and IL6; was generally well-tolerated at all doses tested in the trial; had dose proportional pharmacokinetics with a terminal half-life of 9-12 hours; and had no meaningful food effect or drug-drug interaction (DDI) with methotrexate. ATI-450-PKPD-101 was a first-in-human Phase 1 clinical trial designed to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of orally administered ATI-450 in healthy subjects. No serious adverse events or severe adverse events were reported, and no adverse events led to discontinuation of the study medication. "We believe these data support the progression of ATI-450 into Phase 2 clinical development," said Chief Medical Officer David Gordon. "The potential for an oral small molecule which suppresses multiple proinflammatory cytokines could be very meaningful for the treatment of a number of immuno-inflammatory diseases." Aclaris intends to initiate the first Phase 2 clinical trial in subjects with rheumatoid arthritis in the first half of 2020.

ACRS Aclaris Therapeutics
$1.87 /

+ (+0.00%)

10/22/19 SVB Leerink
Aclaris Therapeutics upgraded to Outperform from Market Perform at SVB Leerink
10/22/19 SVB Leerink
Aclaris Therapeutics upgraded to Outperform at SVB Leerink
10/22/19 SVB Leerink
Aclaris Therapeutics upgraded to Outperform from Market Perform at SVB Leerink
10/11/19 William Blair
William Blair sees 'significant value disconnect' in Aclaris Therapeutics

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UP AFTER EARNINGS:…

UP AFTER EARNINGS: Quad/Graphics (QUAD) up 25.0%... ShotSpotter (SSTI) up 20.1%... Enphase Energy (ENPH) up 11.8%... Herbalife (HLF) up 5.8%... SciPlay (SCPL) up 4.7%... La-Z-Boy (LZB) up 4.6%... Retail Properties of America (RPAI) up 3.0%... Xperi (XPER) up 2.5%... Diamondback Energy (FANG) up 1.9%... Devon Energy (DVN) up 1.9%... TriPointe Group (TPH) up 1.9%... TiVo (TIVO) up 1.5%. ALSO HIGHER: Bed Bath Beyond (BBBY) up 4.0% after guiding FY20 capital allocation. DOWN AFTER EARNINGS: Groupon (GRPN) down 24.9%... Knoll (KNL) down 13.6%... Scientific Games (SGMS) down 10.5%... Blue Apron (APRN) down 9.8%... Amedisys (AMED) down 9.0%... Brookdale Senior Living (BKD) down 6.4%... 10X Genomics (TXG) down 5.1%... LendingClub (LC) down 2.8%... Palomar (PLMR) down 2.8%... bluebird bio (BLUE) down 2.0%... HealthStream (HSTM) down 1.4%... KAR Auction Services (KAR) down 1.4%. Movers as of 18:30ET.

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Initiation
Q2 Holdings initiated with a Neutral at Baird » 17:33
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Earnings
Nutrien sees FY20 adjusted EPS $1.90-$2.60  17:31
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Earnings
Nutrien reports Q4 adjusted EPS 9c » 17:31
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Nutrien

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+0.005 (+0.01%)

Reports Q4 revenue $3.44B…

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Sysco awarded $176.25M Defense Logistics Agency contract » 17:16
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Sysco

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Churchill Downs to invest $5.6M to replace existing track at Turfway Park » 17:16
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Churchill Downs

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Churchill Downs announced…

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Periodicals
Wanda Sports mulls selling Ironman triathlon business, Bloomberg reports » 17:05
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Wanda Sports

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General news
Treasury Market Summary » 17:05
02/18/20
02/18
17:05
02/18/20
17:05

Treasury Market Summary:…

Treasury Market Summary: it was all about Covid-19 worries after Apple warned about production and sales misses due to the virus and related shutdowns. Wall Street tumbled, led by the Dow's near 1% drop, though losses were pared in the afternoon. Treasury yields declined on the risk aversion flows. The long end led the bond rally with the bond falling more than 4 bps as slowing global growth was seen keeping inflation benign. Data included a better than expected jump in the February Empire State index and a dip in the NAHB home builder survey. View the summary.

Earnings
KAR Auction Services sees FY20 adjusted EPS $1.28-$1.38, consensus $1.43 » 17:02
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02/18
17:02
02/18/20
17:02
KAR

KAR Auction

$22.16 /

-0.31 (-1.38%)

Sees FY20 adjusted EBITDA…

Sees FY20 adjusted EBITDA $520M-$540M.

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Earnings
Neenah Paper reports Q4 EPS 87c, consensus 80c » 17:02
02/18/20
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17:02
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17:02
NP

Neenah Paper

$67.96 /

-1.59 (-2.29%)

Reports Q4 revenue…

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Hudbay Minerals announces Chilloroya community formally approved agreement » 17:02
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HBM

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-0.07 (-2.24%)

Hudbay Minerals announced…

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Earnings
KAR Auction Services reports Q4 adjusted EPS 19c, consensus 29c » 17:01
02/18/20
02/18
17:01
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17:01
KAR

KAR Auction

$22.16 /

-0.31 (-1.38%)

Reports Q4 revenue…

Reports Q4 revenue $671.3M, consensus $665.71M.

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Earnings
Retail Opportunity sees FY20 EPS 35c-40c, consensus 37c » 17:00
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17:00
02/18/20
17:00
ROIC

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$17.02 /

-0.06 (-0.35%)

ROIC currently estimates…

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