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MRSN

Mersana Therapeutics

$5.44

0.29 (5.63%)

08:08
01/10/20
01/10
08:08
01/10/20
08:08

Mersana Therapeutics CEO says 2020 has 'potential to be transformational year'

Mersana Therapeutics provided a pipeline update and announced its strategic priorities and anticipated milestones for 2020. Anna Protopapas, President and CEO of Mersana Therapeutics, will review these business updates in a presentation at the upcoming 38th Annual J.P. Morgan Healthcare Conference on Thursday, January 16, 2020. "XMT-1536, a first-in-class NaPi2b-targeting Dolaflexin ADC, is nearing proof of concept and we expect to report important data from both the dose escalation and expansion portions of the study throughout 2020," said Anna Protopapas. "XMT-1536 has shown confirmed responses and durable stable disease in biomarker unselected and heavily pretreated patients. XMT-1536 continues to be both active and well-tolerated at higher doses, and we have increased the dose in both the expansion and dose escalation portions of the study. We have also made significant progress in leveraging our differentiated ADC platforms to build an exciting pipeline of candidates. XMT-1592, a NaPi2b-targeted ADC based on our new Dolasynthen platform, aims to extend our leadership in NaPi2b-directed therapies while also clinically validating the differentiated profile that our Dolasynthen platform has shown preclinically. In addition, we are advancing a first-in-class ADC candidate targeting B7-H4, an antigen with a unique expression profile in the tumor and its microenvironment. Finally, we have developed a STING agonist ADC platform, Immunosynthen, with encouraging preclinical efficacy and tolerability data across multiple targets and anticipate selection of a development candidate later this year. 2020 has the potential to be a transformational year for Mersana as we progress in our efforts to develop novel therapeutics for patients with high unmet need."

MRSN Mersana Therapeutics
$5.44

0.29 (5.63%)

03/11/19
JPMS
03/11/19
DOWNGRADE
JPMS
Underweight
Mersana Therapeutics downgraded to Underweight from Neutral at JPMorgan
JPMorgan analyst Jessica Fye downgraded Mersana Therapeutics to Underweight from Neutral without a price target. With the data for lead asset XMT-1536 at least a year away, the analyst expects the stock to underperform in the near term. Mersana shares reflect "substantial market skepticism already," but upcoming 2019 data releases may not be able to reverse that sentiment, Fye tells investors in a research note. Following the announcement to discontinue development of XMT-1522, the analyst believes there is now greater pressure on XMT-1536 to demonstrate success.
08/20/19
HCWC
08/20/19
NO CHANGE
HCWC
H.C. Wainwright says trial initiation at higher dosing 'bodes well' for Mersana
H.C. Wainwright analyst Debjit Chattopadhyay maintained a Buy rating and $7 price target on Mersana Therapeutics, noting that the expansion cohort dosing of XMT-1536 at 36 mg/m, which was higher than anticipated, "offers significant breathing room, and should clear the air on the safety profile."

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