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ADAP

Adaptimmune

$1.33 /

-0.04 (-2.92%)

05:39
01/13/20
01/13
05:39
01/13/20
05:39

Adaptimmune SPEAR T-cell platform delivers initial responses

Adaptimmune Therapeutics reported two confirmed Partial Responses, or PRs, - one in a patient with liver cancer and one in a patient with melanoma. There are also two unconfirmed PRs - one in a patient with gastro-esophageal junction cancer and one in a patient with head and neck cancer. These data further confirm the potential of Adaptimmune's SPEAR T-cell platform for patients with multiple solid tumors. Data were previously reported showing compelling efficacy with ADP-A2M4 in synovial sarcoma. "These responses demonstrate that our proprietary SPEAR T-cell platform is clearly active and can overcome the challenges of treating a range of solid tumors with a T-cell therapy product," said Adrian Rawcliffe, Adaptimmune's CEO. "These are early results and we need more patient data and durability information to determine which therapies to develop. Nonetheless, this is a critical demonstration of the value of our SPEAR T-cell therapies for people with cancer and a validation of the importance of our proprietary affinity engineering. I couldn't be prouder of the team at Adaptimmune, and we are grateful to the investigators and patients who have put their faith in our treatment. We look forward to presenting data from these trials at future scientific congresses." There continues to be a favorable benefit:risk profile for all products and indications under study. Most adverse events are consistent with those typically experienced by cancer patients undergoing cytotoxic chemotherapy or other cancer immunotherapies. Adverse events (including cytokine release syndrome, neurotoxicity, and prolonged cytopenias) occur at rates consistent with other T-cell therapies, and are managed in keeping with current guidelines.

ADAP Adaptimmune
$1.33 /

-0.04 (-2.92%)

08/01/19 GUGG
Adaptimmune downgraded to Neutral from Buy at Guggenheim
08/02/19 GUGG
Adaptimmune downgraded to Neutral on low near-term visibility at Guggenheim
08/02/19
Fly Intel: Top five analyst downgrades
10/23/19
Adaptimmune management to meet with SunTrust

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Options
Call buyer craps out in Las Vegas Sands » 10:30
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Las Vegas Sands

$63.83 /

-4.01 (-5.91%)

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Options
Pinduoduo call volume above normal and directionally bullish » 10:25
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PDD

Pinduoduo

$36.37 /

-0.96 (-2.57%)

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Conference/Events
Cowen analysts to hold an analyst/industry conference call » 10:25
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Conference/Events
UBS services analyst to hold an analyst/industry conference call » 10:25
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Hot Stocks
GeoVax Labs, BravoVax to collaborate on development of coronavirus vaccine » 10:24
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01/27
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GOVX

GeoVax Labs

$0.00 /

+ (+0.00%)

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Hot Stocks
Fox Sports announces exclusive U.S. English-language rights pact with Concacaf » 10:22
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01/27
10:22
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FOXA

Fox Corp.

$36.50 /

-0.1 (-0.27%)

, FOX

Fox Corp.

$35.99 /

-0.05 (-0.14%)

Fox Sports and Concacaf…

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General news
Treasury Action: yields remain sharply lower on risk aversion » 10:20
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Technical Analysis
NASDAQ market internals summary » 10:17
01/27/20
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$NSD

NASDAQ Market Internals

$0.00 /

+ (+0.00%)

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Periodicals
DraftKings viewed as acquisition target for gaming operators, Casino.org reports » 10:16
01/27/20
01/27
10:16
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10:16
DEAC

Diamond Eagle Acquisition

$14.69 /

+0.3 (+2.08%)

, MGM

MGM Resorts

$30.31 /

-1.26 (-3.99%)

, ERI

Eldorado Resorts

$58.10 /

-1.1 (-1.86%)

, WYNN

Wynn Resorts

$125.04 /

-9.73 (-7.22%)

, LVS

Las Vegas Sands

$63.63 /

-4.21 (-6.21%)

DraftKings, which is…

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Technical Analysis
NYSE market internals summary » 10:16
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10:16
$NYE

NYSE Market Internals

$0.00 /

+ (+0.00%)

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Periodicals
Royal Caribbean tells Bloomberg two sailings suspended due to coronavirus » 10:15
01/27/20
01/27
10:15
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10:15
RCL

Royal Caribbean

$118.87 /

-7.62 (-6.02%)

Royal Caribbean told…

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Options
Wayfair put volume heavy and directionally bearish » 10:15
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01/27
10:15
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W

Wayfair

$102.78 /

-3.935 (-3.69%)

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General news
U.S. new home sales dipped -0.4% in December to a 694k pace » 10:15
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U.S. new home sales…

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General news
Dallas Fed Mfg Survey General Activity Index to be reported at 10:30 » 10:15
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January Dallas Fed Mfg…

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Initiation
Fly Intel: Top five analyst initiations » 10:12
01/27/20
01/27
10:12
01/27/20
10:12
MTNB

Matinas BioPharma

$1.49 /

+0.015 (+1.02%)

, LYV

Live Nation

$71.26 /

-0.79 (-1.10%)

, HAS

Hasbro

$103.02 /

-1.69 (-1.61%)

, MAT

Mattel

$14.04 /

-0.23 (-1.61%)

, EXP

Eagle Materials

$92.62 /

+0.42 (+0.46%)

, INS

Intelligent Systems

$40.50 /

+0.11 (+0.27%)

Catch up on today's…

Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. Matinas BioPharma (MTNB) initiated with an Overweight at Piper Sandler. 2. Live Nation (LYV) initiated with an Outperform at Cowen. 3. Mattel (MAT) initiated with an Overweight at JPMorgan while Hasbro (HAS) was initiated with a Neutral. 4. Eagle Materials (EXP) initiated with a Buy at Citi. 5. Intelligent Systems (INS) initiated with a Buy at BTIG. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.

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Downgrade
Fly Intel: Top five analyst downgrades » 10:12
01/27/20
01/27
10:12
01/27/20
10:12
INTC

Intel

$66.77 /

-1.7 (-2.48%)

, AXP

American Express

$129.42 /

-5.69 (-4.21%)

, XPO

XPO Logistics

$90.05 /

-1.8 (-1.96%)

, EL

Estee Lauder

$195.25 /

-10.07 (-4.90%)

, WYNN

Wynn Resorts

$126.23 /

-8.54 (-6.34%)

Catch up on today's…

Catch up on today's top five analyst downgrades with this list compiled by The Fly: 1. Intel (INTC) downgraded to Market Perform from Outperform at Northland with analyst Gus Richard saying while he sees a number of potential positive and negative catalysts for Intel shares, he does not know which will come first. 2. American Express (AXP) downgraded to Equal Weight from Overweight at Stephens with analyst Vincent Caintic citing valuation. 3. XPO Logistics (XPO) downgraded to Equal Weight from Overweight at Barclays. 4. Estee Lauder (EL) downgraded to Perform from Outperform at Oppenheimer with analyst Rupesh Parikh saying after recent developments in China with the coronavirus coupled with the premium valuation at which shares trade, he no longer views the risk/reward as attractive from current levels. 5. Wynn Resorts (WYNN) downgraded to Neutral from Buy at BofA with analyst Shaun Kelley citing the recent spread of fears and headlines related to the Wuhan coronavirus, pressuring regional travel and Macau traffic. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.

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Upgrade
Fly Intel: Top five analyst upgrades » 10:12
01/27/20
01/27
10:12
01/27/20
10:12
INTC

Intel

$66.77 /

-1.7 (-2.48%)

, AXP

American Express

$129.42 /

-5.69 (-4.21%)

, XPO

XPO Logistics

$90.05 /

-1.8 (-1.96%)

, EL

Estee Lauder

$195.25 /

-10.07 (-4.90%)

, WYNN

Wynn Resorts

$126.23 /

-8.54 (-6.34%)

Catch up on today's…

Catch up on today's top five analyst upgrades with this list compiled by The Fly: 1. Marathon Oil (MRO) upgraded to Buy from Hold at Stifel with analyst Derrick Whitfield saying he believes the company is well positioned to outperform in 2020 based on its commitment to shareholder returns and improving capital efficiency. 2. Denali Therapeutics (DNLI) upgraded to Buy from Neutral at Goldman Sachs analyst Salveen Richter saying he believes Denali is evolving into a triple platform story with a small molecule portfolio targeting mutated genetic targets/pathways; a leverageable multi-modality blood brain barrier Transport Vehicle platform; and a potential next-generation viral vector gene therapy vertical. 3. e.l.f. Beauty (ELF) upgraded to Buy from Hold at Jefferies with analyst Stephanie Wissink saying the stock is down 25% from its multi-year high of $19.96 that was reached on November 7. 4. Chipotle (CMG) upgraded to Neutral from Sell at UBS with analyst Dennis Geiger saying he is increasingly more confident in the sustainability of the company's strong sales and earnings growth over the next couple of years, with results having exceeded his expectations "significantly" over the recent quarters. 5. Biogen (BIIB) upgraded to Buy from Hold at Canaccord with analyst Sumant Kulkarni saying he admits to being "surprised as anyone" by Biogen's "sudden revival" in October of aducanumab for early Alzheimer's disease. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.

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Conference/Events
The Society of Thoracic Surgeons to hold annual meeting » 10:05
01/27/20
01/27
10:05
01/27/20
10:05
ABT

Abbott

$89.15 /

-1.27 (-1.40%)

, ABMD

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$180.53 /

-2.36 (-1.29%)

, ANGO

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$14.47 /

+ (+0.00%)

, ATRC

AtriCure

$36.83 /

-0.71 (-1.89%)

, BDX

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$276.06 /

-2.16 (-0.78%)

, BSX

Boston Scientific

$42.88 /

-0.32 (-0.74%)

, CRY

CryoLife

$29.36 /

-0.64 (-2.13%)

, EW

Edwards Lifesciences

$227.04 /

-3.4 (-1.48%)

, ISRG

Intuitive Surgical

$570.62 /

-18.39 (-3.12%)

, IQV

Iqvia

$157.92 /

-0.215 (-0.14%)

, JNJ

Johnson & Johnson

$148.01 /

-0.31 (-0.21%)

, LMAT

LeMaitre

$36.60 /

+ (+0.00%)

, MDT

Medtronic

$118.98 /

-0.25 (-0.21%)

, MMSI

Merit Medical

$36.00 /

-0.6 (-1.64%)

, OCX

OncoCyte

$2.74 /

-0.06 (-2.14%)

, WTKWY

Wolters Kluwer

$0.00 /

+ (+0.00%)

, ZBH

Zimmer Biomet

$146.74 /

-0.965 (-0.65%)

56th Annual Meeting of…

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Options
AbbVie call volume above normal and directionally bullish » 10:05
01/27/20
01/27
10:05
01/27/20
10:05
ABBV

AbbVie

$85.71 /

+2.18 (+2.61%)

Bullish option flow…

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General news
New Home Sales data reported » 10:02
01/27/20
01/27
10:02
01/27/20
10:02

December New Home Sales…

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General news
Trump says 'in very close communication with China' on coronavirus » 10:02
01/27/20
01/27
10:02
01/27/20
10:02
SPY

SPDR S&P 500 ETF Trust

$324.38 /

-4.36 (-1.33%)

, SPX

S&P 500

$0.00 /

+ (+0.00%)

President Donald Trump…

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Hot Stocks
Stage Stores falls -8.0% » 10:00
01/27/20
01/27
10:00
01/27/20
10:00
SSI

Stage Stores

$3.29 /

-0.34 (-9.37%)

Stage Stores is down…

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Hot Stocks
NIO Inc. falls -13.7% » 10:00
01/27/20
01/27
10:00
01/27/20
10:00
NIO

NIO Inc.

$4.05 /

-0.615 (-13.20%)

NIO Inc. is down -13.7%,…

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Hot Stocks
Build-A-Bear falls -7.0% » 10:00
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10:00
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BBW

Build-A-Bear

$4.13 /

-0.67 (-13.96%)

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Hot Stocks
VelocityShares 3x Long Natural Gas ETN rises 8.0% » 10:00
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VelocityShares 3x Long Natural Gas ETN

$49.82 /

+3.13 (+6.70%)

VelocityShares 3x Long…

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