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LLY

Eli Lilly

$138.01

2.08 (1.53%)

06:37
01/13/20
01/13
06:37
01/13/20
06:37

Eli Lilly announces ORIENT-11 trial met primary endpoint in interim analysis

Eli Lilly jointly announced with Innovent Biologics, the results of a Phase 3 study in China; the ORIENT-11 trial of Tyvyt in combination with Alimta and platinum in first-line advanced or recurrent nonsquamous non-small cell lung cancer, or nsqNSCLC, without sensitive EGFR mutation or ALK rearrangement, met the predefined primary endpoint of progression-free survival, or PFS, in an interim analysis. Based on the interim analysis conducted by the Independent Data Monitoring Committee, or IDMC, sintilimab in combination with Alimta and platinum demonstrated a statistically significant improvement in PFS compared with placebo in combination with Alimta and platinum, which met the pre-defined efficacy criteria. The safety profile of sintilimab in this trial was consistent with previously reported studies, and no new safety signals were identified. Relevant data will be presented at an upcoming medical conference. Based on the IDMC recommendations, Lilly and Innovent will initiate regulatory discussions for registration with the National Medical Products Administration, or NMPA, in China in the near future.

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LLY Eli Lilly
$138.01

2.08 (1.53%)

12/18/19
12/18/19
UPGRADE

Fly Intel: Top five analyst upgrades
Catch up on today's top five analyst upgrades with this list compiled by The Fly: 1. Delta Air Lines (DAL) upgraded to Buy from Hold at Deutsche Bank with analyst Michael Linenberg saying airline stocks are discounting risk from Boeing's (BA) 737 MAX. 2. Eli Lilly (LLY) upgraded to Overweight from Equal Weight at Morgan Stanley with analyst David Risinger saying Lilly offers "strong" earnings growth potential and "significant" pipeline optionality from its base as the smallest U.S. Major Pharma with the lowest margins. 3. Sasol (SSL) upgraded to Buy from Neutral at BofA/Merrill. 4. STAG Industrial (STAG) upgraded to Overweight from Neutral at JPMorgan and to Top Pick from Outperform at RBC Capital. 5. Sabra Health Care (SBRA) upgraded to Neutral from Sell at Citi with analyst Nicholas Joseph saying while the skilled nursing environment remains challenged, 2020 earnings growth is now closer to healthcare REIT peers and Sabra's valuation is fairer following the recent underperformance. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.
12/20/19
STFL
12/20/19
NO CHANGE
STFL
Hold
Stifel says Lexicon 'missed opportunity' with sotagliflozin data
After Lexicon Pharmaceutical (LXRX) announced earlier that sotagliflozin 400 mg achieved the primary endpoint of superiority on A1C reduction versus placebo in the Phase 3 SOTA-EMPA study in type 2 diabetes, Stifel analyst Stephen Willey said he views the inability of sotagliflozin to demonstrate statistically superior HbA1c reduction versus Eli Lilly's (LLY) empagliflozin as a "relative disappointment" and "missed opportunity." The analyst, who had seen this trial as "the best remaining opportunity to establish commercial differentiation" in type 2 diabetes in a crowded field of selective SGLT2i drugs, keeps a Hold rating on Lexicon shares.
12/30/19
ARGS
12/30/19
NO CHANGE
Target $165
ARGS
Buy
Eli Lilly price target raised to $165 from $145 at Argus
Argus analyst David Toung raised his price target on Eli Lilly to $165 and kept his Buy rating, noting the company's FY20 earnings guidance issued earlier this month was stronger than he expected. The analyst also anticipates increased volume and expanded indications for the company's existing drugs supporting its earnings. Toung further cites 2020 benefits for Eli Lilly that include Q3's commercial and regulatory developments such as FDA approval of Reyvow, the additional FDA indication for Taltz, and European Commission's approved update for Trulicity.
01/08/20
PIPR
01/08/20
NO CHANGE
PIPR
Neutral
Eli Lilly still has edge over Blueprint in RET+ lung cancer, says Piper Sandler
After Blueprint Medicines (BPMC) disclosed about 7 months of additional data from the P1/2 ARROW study in patients with RET fusion-positive non-small cell lung cancer, or NSCLC, Piper Sandler analyst Christopher Raymond noted that mDOR was not reached and that CNS response data were not provided. With pralsetinib's durability still not known, he continues to believe Eli Lilly (LLY) "has the edge" in treating later-line NSCLC patients with selpercatinib. Raymond, who prefers "to watch this story play out from the sidelines," maintains a Neutral rating on Blueprint shares.

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AKER

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ECA

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Options
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