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ZYNE

Zynerba

$5.60

0.53 (10.45%)

07:07
01/13/20
01/13
07:07
01/13/20
07:07

Zynerba completes enrollment for Phase 2 BRIGHT trial of Zygel

Zynerba Pharmaceuticals announced the achievement of its enrollment target for the 14-week Phase 2 BRIGHT trial of Zygel for the treatment of pediatric and adolescent patients with autism spectrum disorder, or ASD. The Company expects to announce topline results from this study in the Q2. The 14-week exploratory Phase 2 BRIGHT trial has enrolled 36 patients with ASD at a single clinical site in Australia. The trial is designed to evaluate the efficacy and safety of Zygel in children and adolescents with ASD as confirmed by DSM-5 diagnostic criteria for ASD. Enrolled patients are receiving weight-based initial doses of 250 mg daily or 500 mg daily of Zygel. The efficacy assessments include the Aberrant Behavior Checklist, or ABC, Parent Rated Anxiety Scale - Autism Spectrum Disorder, or PRAS-ASD, Autism Impact Measure, or AIM, the Children's Sleep Habit Questionnaire (CSHQ), and Clinical Global Impression - Severity and Improvement, or CGI-S, CGI-I. After completing dosing in the 14-week period, participants may enroll in a six-month extension trial.

ZYNE Zynerba
$5.60

0.53 (10.45%)

10/21/19
NEED
10/21/19
INITIATION
Target $18
NEED
Buy
Zynerba initiated with a Buy at Needham
Needham analyst Serge Belanger initiated coverage of Zynerba with a Buy rating and $18 price target. The analyst cites the potential of the company's late-stage topical CBD gel product candidate Zygel building a "presence" in the growing CBD therapeutic segment while targeting difficult-to-treat neuropsychiatric conditions and rare epilepsy disorders. Belanger notes that Zygel has so far yielded a positive phase 2 result in patients with Fragile X Syndrome as it improved the patients' "key neuro-behavioral symptoms". The analyst further contends that the current valuation of Zynebra does not fully account for the potential of Zygel becoming a part of the developing therapeutic CBD landscape and believes that the stock offers a "compelling" risk/reward ahead of several key data readouts expected in the first half of 2020.
12/16/19
ADAM
12/16/19
NO CHANGE
Target $18
ADAM
Buy
Zynerba's Zygel may have 'clear place' as DEE treatment, says Canaccord
Canaccord analyst Sumant Kulkarni reiterated a Buy rating and $18 price target on Zynerba after hosting an investor event with the company's New Zealand principal investigator in the BELIEVE 1 study for Zygel for developmental and epileptic encephalopathies. In a research note to investors, Kulkarni says he came away from the event with greater confidence in his view that the Phase 2 data Zynerba announced in September were "misunderstood, especially on safety." Specifically, Kulkarni says Dr. Lynette Sadleir believes Zygel was very well tolerated and that adverse events are "common and expected." If successfully developed, the analyst believes Zygel has a clear place as a DEE treatment.
12/31/19
ROTH
12/31/19
INITIATION
Target $12
ROTH
Buy
Zynerba assumed with a Buy at Roth Capital
Roth Capital analyst Scott Henry assumed coverage of Zynerba with a Buy rating and $12 price target saying the company is an emerging pharmaceutical company focused on cannabinoids. The analyst highlights the company's four key program approaching either clinical readouts or FDA meetings in first half 2020, and believes expectations are low, creating a compelling risk/reward for investors.
12/31/19
12/31/19
NO CHANGE

Fly Intel: Top five analyst actions
Catch up on today's top five analyst actions with this list compiled by The Fly: 1. NIO Inc. (NIO) upgraded to Neutral from Underperform at BofA with analyst Ming Hsun Lee saying the company's launch of a 100kWh battery pack will enhance the cruise range of the ES8 significantly and NIO also announced its third model, the EC6, which will be equipped with with dual motors. 2. Wave Life Sciences (WVE) downgraded to Market Perform from Outperform at SVB Leerink with analyst Mani Foroohar citing limited catalysts until second half of 2020. 3. BellRing Brands (BRBR) initiated with an Equal Weight at Consumer Edge. 4. New Residential (NRZ) initiated with a Buy at Argus. 5. Zynerba (ZYNE) assumed with a Buy at Roth Capital. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.

TODAY'S FREE FLY STORIES

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GOOG

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28.34 (1.95%)

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NFLX

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CMCSK

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CMCSA

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GOOGL

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JWN

Nordstrom

$40.34

-0.15 (-0.37%)

, WMT

Walmart

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BA

Boeing

$324.11

-7.89 (-2.38%)

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VWAGY

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FSLR

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AAPL

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DQ

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SPOT

Spotify

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CE

Celanese

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BYND

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DBD

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UBSFY

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IMVT

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TBLT

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MYO

Myomo

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0.0062 (1.98%)

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  • 21

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SRRA

Sierra Oncology

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  • 21

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SRNE

Sorrento Therapeutics

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-0.15 (-3.40%)

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AKER

Akers Biosciences

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ECA

Encana

$4.09

-0.18 (-4.22%)

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  • 29

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MBRX

Moleculin Biotech

$0.96

0.0122 (1.29%)

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VOD

Vodafone

$20.07

-0.225 (-1.11%)

, BT

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$0.00

(0.00%)

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Vodafone

$20.07

-0.225 (-1.11%)

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$0.00

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16:30
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Options
Preliminary option volume of 28.7M today »

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