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RUBY

Rubius Therapeutics

$9.35 /

+ (+0.00%)

09:42
01/13/20
01/13
09:42
01/13/20
09:42

Rubius Therapeutics announces 2020 objectives

Rubius Therapeutics announced 2020 objectives and operational updates. Pablo J. Cagnoni, M.D., chief executive officer, will present these updates and review 2019 accomplishments today at 9:00 a.m. PST / 12:00 p.m. EST at the 38th Annual J.P. Morgan Healthcare Conference in San Francisco, California. RTX-134 for the Treatment of Phenylketonuria: RTX-134 is an allogeneic cellular therapy product candidate that is genetically engineered to express the enzyme phenylalanine ammonia-lyase inside RTX-134 to degrade toxic levels of phenylalanine that accumulate due to a deficiency in the phenylalanine hydroxylase enzyme. Rubius plans to announce when the first patient has been dosed in the Phase 1b clinical trial evaluating RTX-134 in adults with PKU and expects to provide an update on timing for reporting of initial clinical results at that time. The initial clinical results expected are preliminary safety, longevity of RTX-134 in circulation and proof-of-mechanism as measured by the production of trans-cinnamic acid, a metabolite of phenylalanine when degraded by PAL. RTX-240 for the Treatment of Solid Tumors: RTX-240 is an allogeneic cellular therapy product candidate engineered to replicate the human immune system by broadly stimulating the adaptive and innate immune systems to generate an immune response. RTX-240 expresses 4-1BBL and IL-15TP, a fusion of IL-15 and IL-15 receptor alpha, on the cell surface with the goal of improving anti-tumor activity and overcoming resistance to immunotherapy in patients with solid tumors. Rubius has filed an IND with U.S. FDA for RTX-240 for the treatment of cancer and plans to announce when the first patient has been dosed. GMP grade RTX-240 is expected to be manufactured at Rubius' fully-owned manufacturing facility. RTX-321 for the Treatment of HPV-Positive Tumors: RTX-321 is an allogeneic artificial antigen-presenting cellular therapy product candidate that is engineered to induce a tumor-specific immune response by expanding antigen-specific T cells. RTX-321 expresses an HPV peptide antigen bound to MHC I, 4-1BBL and IL-12 on the cell surface to mimic human T cell-APC interactions. Rubius plans to file an IND for RTX-321 by year-end. GMP grade RTX-321 is expected to be manufactured at Rubius' fully-owned manufacturing facility. Additional Manufacturing Update: Rubius has the potential to significantly expand its manufacturing capabilities at its Smithfield, RI site and plans to stage additional investments based on future supply needs.

RUBY Rubius Therapeutics
$9.35 /

+ (+0.00%)

06/26/19 HCWC
Rubius Therapeutics initiated with a Buy at H.C. Wainwright
07/11/19 HCWC
Rubius' RTX-240 offers differentiated value propositions, says H.C. Wainwright
09/09/19 BARD
Rubius Therapeutics initiated with an Underperform at Baird
09/10/19 BARD
Rubius Therapeutics coverage initiated, dearth of data for platform says Baird

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Turk Telekom upgraded to Buy from Neutral at Goldman Sachs » 19:09
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Earnings
Heritage Commerce reports Q4 EPS 10c, consensus 24c » 19:06
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Heritage Commerce

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UP AFTER EARNINGS:…

UP AFTER EARNINGS: eHealth (EHTH) up 15.6%... Atlassian (TEAM) up 9.7%... Intel (INTC) up 5.2%... NextGen Healthcare (NXGN) up 3.6%... SVB Financial (SIVB) up 3.1%. ALSO HIGHER: Fluor (FLR) up 7.8% after its Stork JV was awarded engineering services contract for Dutch assets... Broadcom (AVGO) up 2.3% after announcing new component deal with Apple. DOWN AFTER EARNINGS: Discover (DFS) down 5.8%... Intuitive Surgical (ISRG) down 2.9%... Skyworks (SWKS) down 2.5%... Banner Corp (BANR) down 2.2%... E-Trade (ETFC) down 2.1%... Covenant Transport (CVTI ) down 1.6%. Movers as of 18:30ET.

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Periodicals
Sonos CEO apologizes for perceived 'planned obsolescence' move, Verge reports » 18:04
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Periodicals
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Insys Therapeutics…

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Periodicals
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Periodicals
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Hot Stocks
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WTFC

Wintrust Financial

$64.70 /

-0.62 (-0.95%)

The dividend is payable…

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Hot Stocks
MPLX raises quarterly cash distribution to 68.75c per unit » 17:32
01/23/20
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The distribution will be…

The distribution will be paid on February 14 to common unitholders of record as of February 4.

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Conference/Events
TD Securities to hold a conference » 17:30
01/23/20
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Financial Services…

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Conference/Events
CFTC Commissioner Quintenz participates in a fireside chat » 17:29
01/23/20
01/23
17:29
01/23/20
17:29

CFTC Commissioner…

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Conference/Events
CFTC Dan Commissioner Berkovitz participates on a panel » 17:28
01/23/20
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17:28
01/23/20
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CFTC Dan Commissioner…

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Earnings
Western Alliance reports Q4 EPS $1.25, consensus $1.20 » 17:25
01/23/20
01/23
17:25
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17:25
WAL

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$57.57 /

+0.33 (+0.58%)

Reports Q4 reveue…

Reports Q4 reveue $287.5M, consensus $286.77M.

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Discover down 4.9% after Q4 results » 17:25
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DFS

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$85.77 /

+0.405 (+0.47%)

Shares of Discover are…

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