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VXRT

Vaxart

$0.53 /

+0.1468 (+38.31%)

08:18
01/22/20
01/22
08:18
01/22/20
08:18

Vaxart announces publication of influenza challenge study results

Vaxart, Inc. (VXRT), a clinical-stage biotechnology company developing oral recombinant vaccines administered by tablet rather than by injection, announced today that the results from its H1 influenza oral tablet vaccine challenge study were published in the Lancet Infectious Diseases. The study demonstrated a single dose with the Vaxart oral tablet H1 influenza vaccine was well tolerated and provided statistically significant protection against H1 influenza infection in the human challenge model. Efficacy results trended favorably when compared to Fluzone, an injectable quadrivalent influenza vaccine and the active comparator in the study. Dr. Stanley A. Plotkin is Emeritus Professor of the University of Pennsylvania and Adjunct Professor of the Johns Hopkins University. Data from the Phase 2 influenza A challenge study demonstrated that Vaxart's oral tablet influenza vaccine generated a 39 percent reduction in clinical disease relative to placebo, compared to a 27 percent reduction by Fluzone. It also reduced infection rates by 47 percent, compared to 43 percent by Fluzone. The tablet vaccine showed a favorable safety profile, similar to placebo. The Phase 2 influenza A challenge trial was a randomized, double-blind study consisting of three groups. Subjects received either a single dose of the Vaxart oral tablet vaccine and a placebo intramuscular injection, a QIV injection and a placebo tablet, or a double placebo. Subjects were challenged intranasally with homologous A strain influenza virus 90-132 days after vaccination. The main objective of the study was to evaluate the percentage of subjects protected by the Vaxart oral tablet vaccine against influenza illness, measured as a reduction in clinical symptoms and laboratory-confirmed homologous influenza A infections, compared to QIV and placebo. The Phase 2 study was completed with support from the Office of Biomedical Advanced Research and Development Authority. Vaxart received a total of $15.7M under a contract from BARDA to support the advanced development of more effective influenza vaccines to ultimately improve seasonal and pandemic influenza preparedness.

VXRT Vaxart
$0.53 /

+0.1468 (+38.31%)

08/15/19 Brookline
Vaxart initiated with a Buy at Brookline
06/27/19 H.C. Wainwright
Vaxart initiated with a Buy at H.C. Wainwright

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