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AGTC

Applied Genetic

$9.86 /

+1.605 (+19.44%)

07:10
01/23/20
01/23
07:10
01/23/20
07:10

Applied Genetic reports six-month data from Phase 1/2 trials in achromatopsia

Applied Genetic Technologies reported interim six-month data from the dose-escalation cohorts of its ongoing Phase 1/2 clinical programs in patients with achromatopsia due to mutation in the ACHM CNGB3 or ACHM CNGA3 genes. The interim results from both studies demonstrate encouraging signs of biologic activity and a favorable safety profile. The company plans to report data from additional dose groups, age groups and time-points in the second half of 2020. The data reported are from 22 patients who have been dosed in the initial groups of the trials, comprising 13 patients in the ACHM CNGB3 trial and 9 patients in the ACHM CNGA3 trial. Data from both trials continue to demonstrate a favorable safety profile with no dose-limiting inflammatory responses observed. These data also demonstrate encouraging signs of biologic activity, as shown by positive changes in light discomfort testing and encouraging patient anecdotes describing real-world improvements in visual function. The company is currently dosing two higher dose groups in adults and three groups of pediatric patients at the three highest dose groups in both trials. The company will use the additional data, which is expected to be available in the second half of 2020, to inform decision-making regarding readiness to move the product candidates to pivotal trials.

AGTC Applied Genetic
$9.86 /

+1.605 (+19.44%)

01/09/20 BMO Capital
Applied Genetic price target raised to $16 from $9 at BMO Capital
01/09/20 Wedbush
Applied Genetic opportunity in XLRP becoming clearer, says Wedbush
01/09/20 H.C. Wainwright
Applied Genetics' XLRP data supports strong pivotal design, says H.C. Wainwright
10/14/19 Roth Capital
Ophthalmic therapies 'could go from 0 to 100 real quick,' says Roth Capital

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