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DMPI

DelMar Pharmaceuticals

$0.54 /

+0.0089 (+1.67%)

08:06
01/29/20
01/29
08:06
01/29/20
08:06

DelMar Pharmaceuticals' VAL-083 for GBM featured in peer-reviewed publication

DelMar Pharmaceuticals announced the publication of previously released interim clinical data in the February 2020 issue of peer-reviewed journal, Glioma. The article highlights results from the first 22 patients of the company's ongoing Phase 2 clinical study investigating the first-line treatment of VAL-083 with radiation therapy in newly-diagnosed, MGMT-unmethylated glioblastoma multiforme or GBM. In the article, of the 22 patients who had completed at least one cycle of treatment as of that date, median progression-free survival with VAL-083 as reported was 9.9 months. For the 18 patients initially receiving the intended treatment dose, median PFS as reported was 10.4 months. The Phase 2 trial is a study testing VAL-083 in combination with standard radiotherapy in GBM patients who have an unmethylated promoter of the methylguanine DNA-methyltransferase gene. The clinical trial in newly-diagnosed GBM patients is designed to determine if first-line treatment with VAL-083 plus radiotherapy can provide improvements over the historical efficacy of standard of care TMZ plus radiotherapy. Myelosuppression was the most common adverse event in the patients assessed, and pharmacokinetic assessments indicated that the levels of VAL-083 were as high in the cerebrospinal fluid as in plasma two hours after infusion.

DMPI DelMar Pharmaceuticals
$0.54 /

+0.0089 (+1.67%)

09/06/19 Maxim
DelMar Pharmaceuticals initiated with a Buy at Maxim

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