2020-02-26 07:44:03 CDNA CareDx
02/26/20 02/2607:44 02/26/2007:44 | CareDx announces publication on AlloSure's ability on ambiguous rejectionsCareDx announces that the American Journal of Transplantation published data on AlloSure's ability to differentiate ambiguous rejections, titled "High levels of dd-cfDNA identifies patients with TCMR 1A and borderline allograft rejection at elevated risk of graft injury." This landmark study, with 11 leading transplant centers, demonstrates that AlloSure is the only dd-cfDNA test that can discriminate clinical relevance of T-cell mediated rejection 1A or borderline biopsies. Currently, there is a lack of consensus on the impact of a TCMR 1A or borderline rejection diagnosis, and significant issues in interobserver pathology assessment. All patients in the study were diagnosed with TCMR 1A or borderline rejection. Those patients with AlloSure scores greater than 0.5% went on to have declining eGFR, a signal of deteriorating graft function and lower prediction of survival. However, those patients with AlloSure scores below 0.5% had almost no change in eGFR. The AJT publication illustrates how AlloSure can risk stratify the population with ambiguous rejections and enable personalized care for transplant patients. |
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