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SINT

Sintx Technologies

$0.34 /

+0.0057 (+1.71%)

09:11
03/23/20
03/23
09:11
03/23/20
09:11

Sintx Technologies files patent related to antipathogenic compositions, methods

SINTX Technologies announced that US and international patent applications were published on March 12, 2020 in which certain claims made in the applications address the potential surface antiviral effect of silicon nitride. The US application is numbered US 2020/0779651 A1 and titled "Antipathogenic Devices and Methods Thereof." The international application is numbered WO 2020/051004 A1 and titled "Antipathogenic Compositions and Methods Thereof." Sonny Bal, Chairman and CEO of SINTX, explained that "As background, SINTX manufactures spine implants made of silicon nitride; these have been used in thousands of spinal fusion surgery patients for over ten years. Basic science and clinical data have repeatedly shown the efficacy and safety of silicon nitride as a spinal implant material. Of interest is a particularly unique property of silicon nitride, i.e., its ability as a biomaterial to resist bacterial adhesion, a precursor to implant-related infections. Silicon nitride's resistance to bacteria has been verified in several in vitro and animal studies that have been published by SINTX scientists, as well as by independent investigators. The impetus for testing silicon nitride against viruses was to extend our understanding of the unique surface chemistry of silicon nitride, and attendant antibacterial properties. In our experiments, we exposed three strains of pathogenic viruses to silicon nitride, namely, Influenza A virus, Feline calicivirus, and Enterococcus 71. These three viral entities were selected because of their different genomic and virion structures, surface isoelectric points, and their propensity to mutate. The individual molecular composition of the capsid proteins and RNA of the selected viruses confer distinct specificity and infectivity characteristics. Of note, these studies were undertaken before the novel COVID-19 coronavirus and its health risks became known. Remarkably, we found inactivation of all three viral strains as early as one minute after exposure to silicon nitride. The primary mechanism of inactivation appears to be RNA cleavage and fragmentation induced by specific, off-stoichiometric chemical reactions, and by the release of reactive nitrogen species on the surface of our material. Our findings with viral inactivation on silicon nitride are consistent with prior knowledge of the other properties of silicon nitride. Mechanistic details of the antibacterial effects of silicon nitride have been previously published by SINTX in the peer literature. A scientific paper related to the antiviral findings is under preparation for peer review and publication. Recent findings published in the New England Journal of Medicine by the National Institute of Allergy and Infectious Diseases show that the COVID-19 coronavirus survives for hours, and even days on materials such as stainless steel, plastic, cardboard, and even copper. Viral persistence on these surfaces contributes to the risk of disease transmission. Ideally, surface inactivation of viral contamination should be effective within minutes, not hours or days. We are anxious to see how the COVID-19 coronavirus will react when exposed to silicon nitride. We are looking for testing facilities and partners who can help us examine the effect of our silicon nitride on the COVID-19 coronavirus, and have applied for federal funding to support this effort. While SINTX has the technology to apply silicon nitride coatings and treatments to a variety of surfaces and materials used in daily living, at this stage the antiviral effects of silicon nitride published in our patent filing reflect in vitro experimental findings only, and we strongly caution against making any inferences beyond that limited data set. We look forward to independent work by others in this area, and seek partners who can help us with further inquiry into the observed antiviral surface properties of silicon nitride. It is our hope as a company to reduce the risk of microbe transmission, contribute to improved global health, and make the world a safer place."

SINT Sintx Technologies
$0.34 /

+0.0057 (+1.71%)

09/11/19 Ascendiant
Sintx Technologies initiated with a Buy at Ascendiant

TODAY'S FREE FLY STORIES

Recommendations
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Recommendations
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Earnings
Notable companies reporting before tomorrow's open » 20:25
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Notable companies…

Notable companies reporting before tomorrow's open, with earnings consensus, include McCormick (MKC), consensus $1.03... Conagra Brands (CAG), consensus 49c.

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Vale upgraded to Buy from Neutral at Goldman Sachs » 20:13
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, AMRN

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$13.59 /

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Shares of Amarin (AMRN)…

Shares of Amarin (AMRN) after plummeting after the United States District Court for the District of Nevada ruled in favor of generic companies Dr. Reddy's (RDY) and Hikma Pharmaceuticals (HKMPF) in the patent litigation for its Vascepa capsule franchise. Six patents on the heart drug, which all expire in 2030, are invalid, ruled District Court Judge Miranda Du. In a statement tonight, Amarin said it "strongly disagrees with the ruling and will vigorously pursue all available remedies, including an appeal of the Court's decision and a preliminary injunction pending appeal to, if an ANDA is approved by FDA, prevent launch of generic versions of Vascepa in the United States." Based on Amarin's review of the FDA's website, an abbreviated new drug approval for Vascepa has not been approved, which would be required for launch of a generic product in U.S., the company added. As such, Amarin does not believe there is an impending generic launch by the litigants that would compete with Vascepa "at this time." Shares of Amarin are down 67%, or $9.04, to $4.54 in after-hours trading.

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Initiation
CACI initiated with an Outperform at William Blair » 19:23
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William Blair analyst Louie DiPalma initiated coverage of CACI International with an Outperform rating.

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Periodicals
New York AG examining Zoom's privacy, security practices, NY Times says » 19:22
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Initiation
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Initiation
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Knol announced a partial…

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On The Fly
Fly Intel: After-Hours Movers » 19:05
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Check out this…

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Hot Stocks
Bluegreen Vacations closes certain sales centers, Cabela's stores » 19:01
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Bluegreen Vacations…

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Periodicals
RBC CEO says will not cut jobs in 2020 amid COVID-19 outbreak, Reuters reports » 19:00
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RY

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+1.09 (+1.86%)

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Conference/Events
Goldman Sachs semiconductors analyst to hold an analyst/industry conference call » 18:55
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Semiconductors &…

Semiconductors & Semiconductors Capital Equipment Analyst Hari discuss recalibrating the COVID-19 impact the industry on an Analyst/Industry conference call to be held on March 30 at 8:30 pm. Webcast Link

Downgrade
Kyushu Electric Power downgraded to Sell from Neutral at Goldman Sachs » 18:48
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$0.00 /

+ (+0.00%)

Goldman Sachs analyst…

Goldman Sachs analyst Takashi Miyazaki downgraded Kyushu Electric Power to Sell from Neutral with a price target of 900 yen, down from 950 yen. The analyst cites his expectation of electricity sales volume decline amid decelerating economic growth, even though the stock price has risen 12% due to the recent slide in fuel prices.

Hot Stocks
Penske Automotive postpones $150M in capex, freezes hiring » 18:32
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$28.39 /

+0.72 (+2.60%)

The company states:…

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Hot Stocks
Abbott CEO: More tests are coming » 18:27
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ABT

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$79.36 /

+4.84 (+6.49%)

In an interview on…

In an interview on CNBC's Mad Money, outgoing Abbott CEO Miles White said, "More tests are coming and capacity expansion is underway. We're properly challenged by COVID-19, but I don't think it can beat us." White noted that he was "particularly impressed" with the response from FDA and the White House. Incoming CEO Robert Ford said the company's new five-minute COVID-19 test is a "game changer." He noted that the summer might be a "very ambitious" timeline for a return to normalcy.

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Hot Stocks
Amarin 'strongly disagrees' with ruling in VASCEPA ANDA litigation » 18:26
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AMRN

Amarin

$13.59 /

+0.34 (+2.57%)

Amarin Corporation…

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Hot Stocks
John Agwunobi assumes role of Herbalife Nutrition CEO » 18:19
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HLF

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$28.98 /

-0.59 (-2.00%)

Herbalife Nutrition…

Herbalife Nutrition announced that John Agwunobi has assumed the role as Chief Executive Officer, succeeding Michael Johnson. The company previously announced the planned succession of Michael Johnson on October 29, 2019. After 17 years at the company, Johnson retires as CEO effective March 30, and will retire as Chairman on April 29, 2020. Since joining the company in 2016, Agwunobi has held a number of positions of increasing responsibility, most recently serving as Herbalife Nutrition's co-president and chief health and nutrition officer and directing the Company's nutrition philosophy. In addition to Agwunobi's transition to CEO, Herbalife Nutrition's co-president and chief strategic officer, John DeSimone has transitioned to president.

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Periodicals
Spirit Airlines to suspend service at 5 northeast airports, Bloomberg reports » 18:12
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SAVE

Spirit Airlines

$12.41 /

-2.29 (-15.58%)

Bloomberg's Justin…

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Periodicals
American Air seeks up to $12B in government aid, Reuters reports » 18:09
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American Airlines plans to apply for up to $12B in government assistance, ensuring no involuntary layoffs or pay reductions in the next six months, Reuters reports, citing a memo to workers from executives. "We certainly hope and expect that by that time, the virus will be contained, Americans will be flying again and we will be back to flying a full schedule," Chief Executive Doug Parker and President Robert Isom said in the memo. Reference Link

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