In a regulatory filing, Lyft disclosed that its CFO Brian Roberts sold 15K shares of common stock on April 8th in a total transaction size of $919.9K, reducing his stake by about 1%.

Innovent Biologics (IVBXF) announced with Eli Lilly (LLY) that the results of the Phase 3 ORIENT-3 study were released today in an oral presentation at the American Association for Cancer Research Annual Meeting 2021. ORIENT-3 is a randomized, open-label, Phase 3 clinical trial evaluating TYVYT, or sintilimab injection, versus docetaxel as a second-line treatment for advanced or metastatic squamous non-small cell lung cancer, or sqNSCLC. A total of 290 patients whose cancer had progressed following first-line treatment with platinum-based chemotherapy were enrolled. Based on the primary analysis population, TYVYT demonstrated a statistically significant improvement in overall survival, or OS, compared to docetaxel, meeting the pre-specified primary endpoint. The median OS was 11.79 months for patients on the TYVYT arm and 8.25 months for those on the docetaxel arm. The median progression-free survival as assessed by investigators was 4.30 months versus 2.79 months, and the confirmed objective response rate was 25.5% versus 2.2%, respectively. Safety was consistent with previous studies of TYVYT, and no new safety signals were identified.

Shares of Opendoor Technologies are up 1.5% afterhours at $19.70. In its daily evening update, ARK Investment Management disclosed a Buy of 633.4K shares of common stock.

In a regulatory filing, Agilent disclosed that its CEO Michael McMullen sold 15,095 shares of common stock on April 8th in a total transaction size of $1.97M, reducing his stake by about 5%.

Mesa Air Group reported Mesa Airlines' operating performance for March 2021. Mesa Airlines reported 28,127 block hours in March 2021, a 15.9% drop from March 2020 "as a result of reduced schedules during the COVID-19 pandemic. The company also reported a controllable completion factor of 99.86 percent and 100 percent for its American and United operations, respectively. For Q2 of fiscal year 2021 ending March 31st, total block hours were 73,942 on 35,270 departures. These block hours are well below our guidance provided on our Q1 fiscal year 2021 Earnings Release. The reduced block hours and departures were the result of the mid-February major winter storm and subsequent Texas power outages impacting our major operations in both Dallas and Houston. During that period, we cancelled almost 1,300 flights representing close to 3,000 block hours while still incurring crew costs."

Air Canada announced that it has entered into a series of debt and equity financing agreements with the Government of Canada, which will allow Air Canada to access up to C$5.879B in liquidity through the Large Employer Emergency Financing Facility program. "Air Canada entered the pandemic more than a year ago with one of the global airline industry's strongest balance sheets relative to its size. We have since raised an additional $6.8 billion in liquidity from our own resources to sustain us through the pandemic, as air traffic ground to a virtual halt in Canada and internationally," said Michael Rousseau, President and Chief Executive Officer of Air Canada. "The additional liquidity program we are announcing today achieves several aligned objectives as it provides a significant layer of insurance for Air Canada, it enables us to better resolve customer refunds of non-refundable tickets, maintain our workforce and re-enter regional markets. Most importantly, this program provides additional liquidity, if required, to rebuild our business to the benefit of all stakeholders and to remain a significant contributor to the Canadian economy through its recovery and for the long term. As vaccine deployments ramp up, we continue to work with the Government of Canada on the evolution of safe and science-based test and quarantine relief measures with a view to safely restarting our sector. We know that Canadians are looking forward to re-connecting with friends and family and taking those long-awaited vacations and business trips and we will be ready to safely connect Canadians within Canada and Canada to the world," said Rousseau.

On a post on the FDA's website, Akouos' treatment for otoferlin gene (OTOF)-mediated hearing loss was granted orphan drug designation. Reference Link

In the context of the participation of China Eastern Airlines to the share capital increase of Air France-KLM, both airline groups have decided to extend the scope of their partnership through: an intensified commercial cooperation and an extended collaboration to noncommercial related activities, and; an increased footprint on the Beijing market, with the Paris-Beijing and Amsterdam-Beijing routes joining the current Joint Venture existing between Air France-KLM and China Eastern Airlines when conditions are satisfied.

Vasta Platform announced the resignation for personal reasons of Clovis Poggetti Junior as its CFO and investor relations officer and the appointment of Bruno Giardino to serve as the company's CFO and investor relations officer. Clovis Poggetti Junior will continue in the company until April 23, during which period he will transfer his activities to Bruno Giardino. Giardino joins the company after having served as the investor relations officer for the company's parent company, Cogna Educacao S.A., since March 2020.

The company states: "Safeguard Scientifics announced the exit of our ownership interest in Zipnosis. Safeguard received $3.3M of initial cash proceeds and a preferred equity interest in Bright Health Group, a national integrated healthcare company. The majority of the consideration we received in the transaction is reflected in this preferred equity interest. Additional cash proceeds may be received from the final determinations of net working capital and the resolution of various escrow contingencies. Safeguard will report a gain on the sale of the Zipnosis ownership interest for the quarter ended March 31, 2021, based on the total value received from the transaction."