2020-06-08 08:16:44 CBIO Catalyst Biosciences
06/08/20 06/0808:16 06/08/2008:16 | Catalyst Biosciences announces presentations at hemophilia virtual summitCatalyst Biosciences announced oral and poster presentations at the upcoming World Foundation of Hemophilia Virtual Summit, taking place from June 14-19, 2020. The open-label Phase 2b study of dalcinonacog alfa, a next-generation subcutaneously administered Factor IX for the treatment of hemophilia B was designed to evaluate daily SQ dosing and the ability to maintain protective steady state FIX levels above 12% in six individuals with severe hemophilia B. Each subject received a single intravenous dose, followed by daily SQ doses of DalcA for 28 days whereby the pharmacokinetics, pharmacodynamics, safety, tolerability and anti-drug antibody formation were monitored. In February 2020, Catalyst Biosciences reported positive interim efficacy and safety data from its Phase 2b trial in an oral presentation at the 13th Annual Congress of the European Association for Haemophilia and Allied Disorders. Blouse will present data from preclinical studies of Catalyst's hemophilia B gene therapy CB 2679d-GT, a novel chimeric AAV capsid expressing the Company's proprietary enhanced potency FIX variant that may reduce the vector dose required in gene therapy, while maintaining high FIX levels. |
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