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NNVC

NanoViricides

$6.51 /

+0.11 (+1.72%)

06:25
06/09/20
06/09
06:25
06/09/20
06:25

NanoViricides signs MoU for human coronavirus drug development license

NanoViricides reported that it has signed a Memorandum of Understanding, or MoU, with respect to anti-viral treatments for coronavirus derived human infections with TheraCour Pharma. NanoViricides said in a release, "The MoU specifically provides a limited, exclusive license to all research and development in the Field for further research and development purposes towards human clinical trials. NanoViricides intends to retain an independent consultant for the evaluation of the assets in order to develop the full license agreement. NanoViricides has been working on drug development to treat the SARS-CoV-2 infection in COVID-19 patients since January, 2020. Prior to this, the Company had engaged in limited research and development work for the treatment of MERS coronavirus during 2014 which allowed for rapid drug candidate identification against SARS-CoV-2. The MERS coronavirus program was set aside as the 2014 outbreak remained contained. The Company has found that the broad-spectrum anti-coronavirus drug candidates that it is developing were several times more effective than favirpravir in cell culture assays against two different coronaviruses, namely hCoV-229E, and hCoV-NL63. These circulating coronaviruses use distinctly different, but related cellular receptors, namely APN for hCoV-229E and ACE2 for hCoV-NL63. The Company believes the fact that these nanoviricides anti-coronavirus drug candidates are highly effective against two distinctly different coronaviruses that use different cellular receptors is very significant. Specifically, it provides a rational basis to scientists indicating that even if the SARS-CoV-2 coronavirus mutates, the nanoviricides can be expected to continue to remain effective. The Company has also found that these drug candidates showed strong effectiveness in an animal model of human coronavirus disease, potentially superior to remdesivir in this particular model, although no firm conclusions to that effect can be drawn with the limited dataset at present. The Company employed hCoV-NL63 in this animal study, because hCoV-NL63 binds to the same cell receptor, namely ACE2, as does SARS-CoV-2 and the 2002-03 SARS-CoV. NL-63 causes clinical pathology in humans that is similar to SARS-CoV-2, but much milder. Thus this virus is expected to be a good surrogate for SARS-CoV-2. The Company believes that it now has broad-spectrum anti-coronavirus drug candidates that are worthy of human clinical trials based on their effectiveness in cell culture and animal models. Importantly, nanoviricides are designed to act by a novel mechanism of action, trapping the virus particle like the "Venus-fly-trap" flower does for insects. Antibodies, in contrast, only label the virus for other components of the immune system to take care of. It is well known that the immune system is not functioning properly at least in severe COVID-19 patients. Prior to filing for human clinical trials, NanoViricides plans on conducting studies to further determine the effectiveness against SARS-CoV-2, perform drug development studies for safety/toxicology, and request a pre-IND Meeting with the FDA for regulatory guidance. Human coronavirus NL63 uses the same ACE2 receptor as the SARS-CoV-2 that causes CoVID-19. Both in terms of its clinical pathology, and its receptor usage, it is known to be very similar to SARS-CoV-2, except much milder. Therefore the Company believes hCoV-NL63 is a good surrogate model for therapeutics development against SARS-CoV-2. HCoV-NL63 can be studied in a BSL2 lab whereas SARS-CoV-2 currently requires a BSL3 or BSL4 facility."

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Goodyear Tire names CTO Chris Helsel as SVP, Global Operations » 12:03
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Recommendations
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Desjardins analyst Doug…

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BMO Bank of Montreal
$85.04 /

-1.25 (-1.45%)

BMO Bank of Montreal
$85.04 /

-1.25 (-1.45%)

02/24/21 Canaccord
Bank of Montreal price target raised to C$112.50 from C$106.50 at Canaccord
02/24/21 National Bank
Bank of Montreal price target raised to C$113 from C$102 at National Bank
02/24/21 RBC Capital
Bank of Montreal price target raised to C$125 from C$110 at RBC Capital
02/24/21 Scotiabank
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Whitecap Resources

$0.00 /

+ (+0.00%)

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SPGYF Whitecap Resources
$0.00 /

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-1.24 (-7.29%)

Metromile announced Junna…

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MILE Metromile
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Trican Well Service

$0.00 /

+ (+0.00%)

RBC Capital analyst Keith…

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TOLWF Trican Well Service
$0.00 /

+ (+0.00%)

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Chubb board to recommend 28th consecutive annual dividend increase » 12:01
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CB

Chubb

$166.74 /

-4.09 (-2.39%)

Chubb Limited announced…

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CB Chubb
$166.74 /

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02/04/21
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Warrior Met Coal

$21.08 /

-4.515 (-17.64%)

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$21.08 /

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$21.08 /

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U.S. Physical Therapy

$111.71 /

-30.295 (-21.33%)

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USPH U.S. Physical Therapy
$111.71 /

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U.S. Physical Therapy price target raised to $100 from $95 at Barrington
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PING Ping Identity
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Revolve Group

$43.18 /

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RVLV Revolve Group
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$43.18 /

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Brookdale Senior Living rises 23.4% » 12:00
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Brookdale Senior Living

$6.06 /

+1.16 (+23.67%)

Brookdale Senior Living…

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BKD Brookdale Senior Living
$6.06 /

+1.16 (+23.67%)

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$6.06 /

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$6.06 /

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GameStop

$136.00 /

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GameStop is up 47.2%, or…

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GME GameStop
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Recommendations
National Bank of Canada price target raised to C$88 from C$81 at RBC Capital » 11:59
02/25/21
02/25
11:59
02/25/21
11:59
NTIOF

National Bank of Canada

$0.00 /

+ (+0.00%)

RBC Capital analyst Darko…

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NTIOF National Bank of Canada
$0.00 /

+ (+0.00%)

11:57 Today Scotiabank
National Bank of Canada price target raised to C$98 from C$89 at Scotiabank
11:28 Today TD Securities
National Bank of Canada price target raised to C$85 from C$79 at TD Securities
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National Bank of Canada upgraded to Outperform from Market Perform at BMO
02/17/21 Scotiabank
National Bank of Canada price target raised to C$89 from C$88 at Scotiabank
Recommendations
High Liner Foods price target raised to C$13 from C$11 at RBC Capital » 11:59
02/25/21
02/25
11:59
02/25/21
11:59
HLNFF

High Liner Foods

$0.00 /

+ (+0.00%)

RBC Capital analyst…

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HLNFF High Liner Foods
$0.00 /

+ (+0.00%)

11:56 Today Scotiabank
High Liner Foods price target raised to C$14.50 from C$11.50 at Scotiabank
11/09/20 RBC Capital
High Liner Foods price target raised to C$11 from C$10 at RBC Capital
11/09/20 BMO Capital
High Liner Foods price target raised to C$11 from C$9.50 at BMO Capital
11/09/20 Scotiabank
High Liner Foods price target raised to C$11.50 from C$9.50 at Scotiabank
Recommendations
Chemtrade Logistics price target raised to C$8 from C$7 at RBC Capital » 11:59
02/25/21
02/25
11:59
02/25/21
11:59
CGIFF

Chemtrade Logistics

$0.00 /

+ (+0.00%)

RBC Capital analyst…

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CGIFF Chemtrade Logistics
$0.00 /

+ (+0.00%)

11:53 Today Scotiabank
Chemtrade Logistics price target raised to C$7.50 from C$6 at Scotiabank
01/15/21 Raymond James
Chemtrade Logistics upgraded to Outperform from Market Perform at Raymond James
12/21/20 CIBC
Chemtrade Logistics upgraded to Outperformer from Neutral at CIBC
11/16/20 BMO Capital
Chemtrade Logistics price target lowered to C$6 from C$6.50 at BMO Capital
Recommendations
Torex Gold Resources price target lowered to C$29 from C$30 at Scotiabank » 11:58
02/25/21
02/25
11:58
02/25/21
11:58
TORXF

Torex Gold Resources

/

+

Scotiabank analyst Trevor…

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TORXF Torex Gold Resources
/

+

02/08/21 CIBC
Torex Gold Resources price target lowered to C$26.50 from C$28.50 at CIBC
01/15/21 BMO Capital
Torex Gold Resources price target lowered to C$35 from C$36 at BMO Capital
01/11/21 Scotiabank
Torex Gold Resources price target lowered to C$30 from C$34 at Scotiabank
01/08/21 BMO Capital
Torex Gold Resources price target raised to C$36 from C$35 at BMO Capital
Recommendations
Royal Bank of Canada price target raised to C$133 from C$129 at Scotiabank » 11:58
02/25/21
02/25
11:58
02/25/21
11:58
RY

Royal Bank of Canada

$88.82 /

-0.57 (-0.64%)

Scotiabank analyst Meny…

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RY Royal Bank of Canada
$88.82 /

-0.57 (-0.64%)

RY Royal Bank of Canada
$88.82 /

-0.57 (-0.64%)

11:28 Today TD Securities
Royal Bank of Canada price target raised to C$125 from C$120 at TD Securities
11:24 Today National Bank
Royal Bank of Canada price target raised to C$123 from C$117 at National Bank
08:45 Today Canaccord
Royal Bank of Canada price target raised to C$123 from C$16 at Canaccord
02/18/21 Canaccord
Canaccord upgrades Royal Bank to Buy on improved valuation
RY Royal Bank of Canada
$88.82 /

-0.57 (-0.64%)

Recommendations
National Bank of Canada price target raised to C$98 from C$89 at Scotiabank » 11:57
02/25/21
02/25
11:57
02/25/21
11:57
NTIOF

National Bank of Canada

$0.00 /

+ (+0.00%)

Scotiabank analyst Sumit…

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NTIOF National Bank of Canada
$0.00 /

+ (+0.00%)

11:28 Today TD Securities
National Bank of Canada price target raised to C$85 from C$79 at TD Securities
05:03 Today BMO Capital
National Bank of Canada upgraded to Outperform from Market Perform at BMO
02/17/21 Scotiabank
National Bank of Canada price target raised to C$89 from C$88 at Scotiabank
02/16/21 Barclays
National Bank of Canada price target raised to C$81 from C$78 at Barclays
Recommendations
High Liner Foods price target raised to C$14.50 from C$11.50 at Scotiabank » 11:56
02/25/21
02/25
11:56
02/25/21
11:56
HLNFF

High Liner Foods

/

+

Scotiabank analyst George…

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HLNFF High Liner Foods
/

+

11/09/20 RBC Capital
High Liner Foods price target raised to C$11 from C$10 at RBC Capital
11/09/20 BMO Capital
High Liner Foods price target raised to C$11 from C$9.50 at BMO Capital
11/09/20 Scotiabank
High Liner Foods price target raised to C$11.50 from C$9.50 at Scotiabank
08/13/20 BMO Capital
High Liner Foods price target raised to C$9.50 from C$7 at BMO Capital
Recommendations
Gran Tierra price target raised to C$1 from C$0.65 at Scotiabank » 11:56
02/25/21
02/25
11:56
02/25/21
11:56
GTE

Gran Tierra

$0.93 /

-0.0557 (-5.63%)

Scotiabank analyst Gavin…

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GTE Gran Tierra
$0.93 /

-0.0557 (-5.63%)

GTE Gran Tierra
$0.93 /

-0.0557 (-5.63%)

02/12/21 RBC Capital
Gran Tierra price target raised to C$1 from C$0.70 at RBC Capital
01/14/21 Scotiabank
Gran Tierra price target raised to C$0.65 from C$0.55 at Scotiabank
10/16/20 National Bank
Gran Tierra price target lowered to C$0.40 from C$0.50 at National Bank
08/06/20 Peel Hunt
Gran Tierra upgraded to Buy from Hold at Peel Hunt
GTE Gran Tierra
$0.93 /

-0.0557 (-5.63%)

GTE Gran Tierra
$0.93 /

-0.0557 (-5.63%)

Recommendations
Goodfood Market price target lowered to C$13 from C$14 at Scotiabank » 11:56
02/25/21
02/25
11:56
02/25/21
11:56
GDDFF

Goodfood Market

/

+

Scotiabank analyst George…

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GDDFF Goodfood Market
/

+

GDDFF Goodfood Market
/

+

11:23 Today National Bank
Goodfood Market price target lowered to C$13.75 from C$14.25 at National Bank
01/14/21 National Bank
Goodfood Market price target raised to C$14.25 from C$12.75 at National Bank
01/14/21 Scotiabank
Goodfood Market price target raised to C$14 from C$11 at Scotiabank
01/08/21 Canaccord
Goodfood Market price target raised to C$14.50 from C$12.50 at Canaccord
Recommendations
Equitable Group price target raised to C$146 from C$136 at Scotiabank » 11:55
02/25/21
02/25
11:55
02/25/21
11:55
EQGPF

Equitable Group

$0.00 /

+ (+0.00%)

Scotiabank analyst Phil…

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EQGPF Equitable Group
$0.00 /

+ (+0.00%)

11:28 Today TD Securities
Equitable Group price target raised to C$155 from C$130 at TD Securities
02/24/21 BMO Capital
Equitable Group price target raised to C$137 from C$107 at BMO Capital
02/24/21 National Bank
Equitable Group price target raised to C$160 from C$138 at National Bank
02/24/21 Stifel
Equitable Group price target raised to C$170 from C$130 at Stifel
Options
Tapestry put volume heavy and directionally bearish » 11:55
02/25/21
02/25
11:55
02/25/21
11:55
TPR

Tapestry

$41.99 /

+0.31 (+0.74%)

Bearish flow noted in…

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TPR Tapestry
$41.99 /

+0.31 (+0.74%)

TPR Tapestry
$41.99 /

+0.31 (+0.74%)

02/22/21 Credit Suisse
Tapestry upgraded to Outperform with $50 target at Credit Suisse
02/22/21 Credit Suisse
Tapestry upgraded to Outperform from Neutral at Credit Suisse
02/16/21 Piper Sandler
Tapestry price target raised to $45 from $42 at Piper Sandler
02/09/21 Telsey Advisory
Tapestry upgraded to Outperform from Market Perform at Telsey Advisory
TPR Tapestry
$41.99 /

+0.31 (+0.74%)

TPR Tapestry
$41.99 /

+0.31 (+0.74%)

TPR Tapestry
$41.99 /

+0.31 (+0.74%)

Conference/Events
Twitter to host virtual analyst day » 11:55
02/25/21
02/25
11:55
02/25/21
11:55
TWTR

Twitter

$78.80 /

+6.89 (+9.58%)

Virtual Analyst Day to be…

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TWTR Twitter
$78.80 /

+6.89 (+9.58%)

TWTR Twitter
$78.80 /

+6.89 (+9.58%)

10:07 Today KeyBanc
KeyBanc says Twitter guide reinforces view that Street understating improvement
08:47 Today BMO Capital
Twitter price target raised to $75 from $45 at BMO Capital
02/22/21 Baird
Twitter price target raised to $75 from $65 at Baird
02/18/21 JPMorgan
JPMorgan still prefers Twitter to Snap into analyst days next week
TWTR Twitter
$78.80 /

+6.89 (+9.58%)

TWTR Twitter
$78.80 /

+6.89 (+9.58%)

TWTR Twitter
$78.80 /

+6.89 (+9.58%)

TWTR Twitter
$78.80 /

+6.89 (+9.58%)

Recommendations
Chemtrade Logistics price target raised to C$7.50 from C$6 at Scotiabank » 11:53
02/25/21
02/25
11:53
02/25/21
11:53
CGIFF

Chemtrade Logistics

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Scotiabank analyst Ben…

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01/15/21 Raymond James
Chemtrade Logistics upgraded to Outperform from Market Perform at Raymond James
12/21/20 CIBC
Chemtrade Logistics upgraded to Outperformer from Neutral at CIBC
11/16/20 BMO Capital
Chemtrade Logistics price target lowered to C$6 from C$6.50 at BMO Capital
11/16/20 National Bank
Chemtrade Logistics price target lowered to C$5.50 from C$6.25 at National Bank

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