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AYLA

Ayala Pharmaceuticals

$13.73 /

+1.28 (+10.28%)

07:05
09/18/20
09/18
07:05
09/18/20
07:05

Ayala Pharmaceuticals presents interim data from Phase 2 ACCURACY trial of AL101

Ayala Pharmaceuticals announced positive interim results from the ongoing Phase 2 ACCURACY clinical trial of AL101 for the treatment of recurrent/metastatic adenoid cystic carcinoma harboring Notch-activating mutations in a mini oral presentation at the European Society for Medical Oncology Virtual Congress 2020. The ongoing Phase 2 ACCURACY clinical trial is an open-label, single-arm, multi-center study to assess the clinical activity of AL101 using radiographic assessments of patients with R/M ACC demonstrating disease progression within 6 months prior to dosing. The Company is evaluating the safety and efficacy of AL101 for the treatment of R/M ACC with Notch-activating mutations in two dose cohorts, 4mg once per week and 6mg QW. Dosing for the 6mg QW cohort commenced in March 2020 and is currently enrolling up to 42 subjects. As of July 30, 2020, of the 45 subjects who were enrolled in the 4 mg QW cohort, 40 were evaluable for efficacy for a best response by investigators using RECIST 1.1 criteria. Partial responses were observed in six subjects and stable disease was observed in 21 subjects, yielding a 68% disease control rate; Approximately 40% of evaluable patients remained on drug for at least six months after entering the study with disease progression, including two patients treated beyond progression; and Pharmacokinetics results were similar to those of the AL101 Phase 1 study with no major effect by CYP inhibitors or substrates on AL101 exposure. AL101 was generally observed to be well-tolerated, with most adverse events being mild to moderate in severity: Most treatment related adverse events were of grade 1/2 severity; and The most common TRAEs of any grade included diarrhea of which 4% was grade 3, fatigue of which 4% was grade 3, nausea of which 2% was grade 3 and hypophosphatemia of which 4% was grade 3.

  • 19

    Sep

  • 08

    May

AYLA Ayala Pharmaceuticals
$13.73 /

+1.28 (+10.28%)

06/10/20
Fly Intel: Top five analyst initiations
06/10/20 Raymond James
Ayala Pharmaceuticals initiated with an Outperform at Raymond James
06/09/20 Raymond James
Ayala Pharmaceuticals initiated with an Outperform at Raymond James
06/02/20 Jefferies
Ayala Pharmaceuticals initiated with a Hold at Jefferies

TODAY'S FREE FLY STORIES

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$11.27 /

+0.13 (+1.17%)

, RHHBY

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+ (+0.00%)

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PRTA Prothena
$11.27 /

+0.13 (+1.17%)

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+ (+0.00%)

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Syndicate
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Earnings
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$63.11 /

+1.86 (+3.04%)

Reports Q3 revenue…

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Earnings
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Earnings
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10/20/20
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Hancock Whitney

$22.39 /

+0.79 (+3.66%)

Reports Q3 book value per…

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HWC Hancock Whitney
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+0.79 (+3.66%)

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$22.39 /

+0.79 (+3.66%)

Hot Stocks
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$526.65 /

-4.01 (-0.76%)

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Hot Stocks
Xeris granted fast track designation by FDA for XP-0863 » 16:09
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Xeris Pharmaceuticals

$5.30 /

-0.22 (-3.99%)

Xeris Pharmaceuticals…

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XERS Xeris Pharmaceuticals
$5.30 /

-0.22 (-3.99%)

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  • 26
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XERS Xeris Pharmaceuticals
$5.30 /

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$5.30 /

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Earnings
Bank First National reports Q3 EPS $1.42, consensus $1.03 » 16:09
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BFC

Bank First National

$62.30 /

+0.2 (+0.32%)

Reports Q3 provision for…

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BFC Bank First National
$62.30 /

+0.2 (+0.32%)

Hot Stocks
WD-40 CEO says saw demand for products 'linked to renovation trends' » 16:09
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WD-40

$198.00 /

+2.23 (+1.14%)

"Fiscal year 2020…

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WDFC WD-40
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+2.23 (+1.14%)

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Hot Stocks
IAA awarded patent for system, method of auction management » 16:09
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$56.92 /

+0.04 (+0.07%)

IAA announced it has been…

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+0.04 (+0.07%)

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Earnings
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$10.00 /

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Hot Stocks
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Hot Stocks
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Charter price target raised to $750 from $700 at Morgan Stanley
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Comcast price target raised to $57 from $49 at Morgan Stanley
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NFLX Netflix
$526.10 /

-4.56 (-0.86%)

DIS Disney
$125.06 /

+0.8 (+0.64%)

CMCSA Comcast
$44.30 /

-0.01 (-0.02%)

T AT&T
$26.80 /

-0.09 (-0.33%)

NFLX Netflix
$526.10 /

-4.56 (-0.86%)

DIS Disney
$125.06 /

+0.8 (+0.64%)

CMCSA Comcast
$44.30 /

-0.01 (-0.02%)

T AT&T
$26.80 /

-0.09 (-0.33%)

NFLX Netflix
$526.10 /

-4.56 (-0.86%)

DIS Disney
$125.06 /

+0.8 (+0.64%)

CMCSA Comcast
$44.30 /

-0.01 (-0.02%)

T AT&T
$26.80 /

-0.09 (-0.33%)

NFLX Netflix
$526.10 /

-4.56 (-0.86%)

DIS Disney
$125.06 /

+0.8 (+0.64%)

CMCSA Comcast
$44.30 /

-0.01 (-0.02%)

T AT&T
$26.80 /

-0.09 (-0.33%)

Earnings
Nicolet Bankshares reports Q3 EPS $1.72, consensus $1.40 » 16:07
10/20/20
10/20
16:07
10/20/20
16:07
NCBS

Nicolet Bankshares

$60.48 /

+0.48 (+0.80%)

The net interest margin…

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NCBS Nicolet Bankshares
$60.48 /

+0.48 (+0.80%)

NCBS Nicolet Bankshares
$60.48 /

+0.48 (+0.80%)

10/09/20 Stephens
Stephens starts Nicolet Bankshares at Equal Weight, citing valuation
10/09/20 Stephens
Nicolet Bankshares initiated with an Equal Weight at Stephens
NCBS Nicolet Bankshares
$60.48 /

+0.48 (+0.80%)

Initiation
Humanigen initiated with an Overweight at Cantor Fitzgerald » 16:07
10/20/20
10/20
16:07
10/20/20
16:07
HGEN

Humanigen

$13.74 /

+0.33 (+2.46%)

Cantor Fitzgerald analyst…

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HGEN Humanigen
$13.74 /

+0.33 (+2.46%)

HGEN Humanigen
$13.74 /

+0.33 (+2.46%)

10/14/20 H.C. Wainwright
Humanigen initiated with a Buy at H.C. Wainwright
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Humanigen initiated with a Buy at Roth Capital
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HGEN Humanigen
$13.74 /

+0.33 (+2.46%)

Syndicate
VERB Technology files to sell 8.39M shares of common stock for holders  16:07
10/20/20
10/20
16:07
10/20/20
16:07
VERB

Verb Technology

$1.20 /

-0.02 (-1.64%)

 
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VERB Verb Technology
$1.20 /

-0.02 (-1.64%)

VERB Verb Technology
$1.20 /

-0.02 (-1.64%)

07/13/20 Alliance Global Partners
Alliance Global Partners keeps a Buy rating on VERB after preliminary results
VERB Verb Technology
$1.20 /

-0.02 (-1.64%)

  • 22
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Hot Stocks
Apyx Medical announces two peer-reviewed publications on Helium Plasma » 16:07
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APYX

Apyx Medical

$5.84 /

+0.11 (+1.92%)

Apyx Medical announced…

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APYX Apyx Medical
$5.84 /

+0.11 (+1.92%)

APYX Apyx Medical
$5.84 /

+0.11 (+1.92%)

06/22/20 Piper Sandler
Apyx Medical's expanded international sale 'important', says Piper Sandler
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Apyx Medical price target lowered to $7 from $10 at Piper Sandler
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Apyx Medical shares likely to continue to appreciate, says JMP Securities
11/11/19 Piper Jaffray
Apyx Medical price target raised to $10 from $8 at Piper Jaffray
APYX Apyx Medical
$5.84 /

+0.11 (+1.92%)

APYX Apyx Medical
$5.84 /

+0.11 (+1.92%)

Hot Stocks
iRobot sees FY20 non-GAAP EPS $3.43-$3.53, consensus $2.53 » 16:06
10/20/20
10/20
16:06
10/20/20
16:06
IRBT

iRobot

$96.42 /

+5.07 (+5.55%)

Sees FY20 revenue…

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IRBT iRobot
$96.42 /

+5.07 (+5.55%)

IRBT iRobot
$96.42 /

+5.07 (+5.55%)

10/09/20 Northland
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iRobot downgraded to Neutral from Buy at Colliers
07/01/20 Citi
iRobot price target raised to $85 from $60 at Citi
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Fly Intel: Top five analyst downgrades
IRBT iRobot
$96.42 /

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IRBT iRobot
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IRBT iRobot
$96.42 /

+5.07 (+5.55%)

Earnings
Tenet reports Q3 adjusted EPS 64c, consensus 31c » 16:06
10/20/20
10/20
16:06
10/20/20
16:06
THC

Tenet

$28.73 /

+0.54 (+1.92%)

Reports Q3 revenue…

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THC Tenet
$28.73 /

+0.54 (+1.92%)

THC Tenet
$28.73 /

+0.54 (+1.92%)

09/21/20
Fly Intel: Top five analyst downgrades
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Tenet downgraded to Underweight on stalled hospital recovery JPMorgan
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Tenet price target raised to $35 from $30 at RBC Capital
THC Tenet
$28.73 /

+0.54 (+1.92%)

THC Tenet
$28.73 /

+0.54 (+1.92%)

THC Tenet
$28.73 /

+0.54 (+1.92%)

THC Tenet
$28.73 /

+0.54 (+1.92%)

Hot Stocks
CrossFirst Bancshares announces up to $20M share repurchase program » 16:06
10/20/20
10/20
16:06
10/20/20
16:06
CFB

CrossFirst Bancshares

$9.28 /

-0.02 (-0.22%)

The company's board…

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CFB CrossFirst Bancshares
$9.28 /

-0.02 (-0.22%)

CFB CrossFirst Bancshares
$9.28 /

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07/20/20 SunTrust
CrossFirst Bancshares initiated with a Hold at SunTrust
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CrossFirst Bancshares initiated with a Buy at Sandler O'Neill
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$9.28 /

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