Kymera Therapeutics to present at Annual Targeted Protein Degradation Summit

Kymera Therapeutics will share two key presentations at the 3rd Annual Targeted Protein Degradation Summit on Oct. 14 and 15. Kymera Co-Founder, President and CEO, Nello Mainolfi, PhD, will deliver a keynote presentation, "Targeted Protein Degradation Beyond Oncology," and share recent data related to the company's IRAK4 program including findings from the company's non-interventional trial in hidradenitis suppurativa patients. Haojing Rong, PhD, Vice President of Pre-Clinical Development, will present on Kymera's efforts to elucidate preclinical pharmacokinetic/pharmacodynamic relationships to predict clinical PK/PD. "Targeted Protein Degradation: Beyond Oncology" will be presented by Dr. Mainolfi, PhD, Co-Founder, President and Chief Executive Officer of Kymera on Oct. 15 at 9:00 AM ET. Dr. Mainolfi will present on the company's Pegasus platform and approach to target selection, focusing on the IRAK4 degrader program in immunology/inflammation, and will present interim findings from a non-interventional trial evaluating IRAK4 expression and the activity of Kymera's lead IRAK4 protein degrader KT-474 in hidradenitis suppurativa and atopic dermatitis. Data were first shared during a poster presentation at the 5th Annual Symposium on Hidradenitis Suppurativa Advances on October 9th, 2020. Key findings presented demonstrated that IRAK4 levels were higher in diseased compared to unaffected skin, further supporting the relevance of the IRAK4 signaling pathway in HS. The study also showed that ex vivo incubation of HS blood with Kymera's protein degrader KT-474 reduced IRAK4 to a level approaching the lower limits of detection across all PBMC subsets. "PK/PD Relationship in Targeted Protein Degradation" will be presented by Dr. Rong, PhD, Vice President of Pre-Clinical Development on Oct. 14 at 4:00 PM ET. Kymera's second presentation will center on the critical need to understand key principles of PK/PD relationships in preclinical species for this new modality and use these learnings to establish optimal dosing paradigms and schedules in preclinical species and eventually to predict human PK/PD and active doses as accurately as possible.