2021-01-12 08:11:26 GILD Gilead
Vir Biotechnology
01/12/21 01/1208:11 01/12/2108:11 | Gilead, Vir Biotechnology establish collaboration for chronic HBVGilead Sciences (GILD) and Vir Biotechnology (VIR) announced that the companies have entered into a clinical collaboration to evaluate novel therapeutic combination strategies aimed at developing a functional cure for chronic hepatitis B virus. The companies plan to initiate a Phase 2 trial evaluating combination therapy for both treatment-experienced and treatment-naive people living with HBV. The multi-arm trial will evaluate different combinations of selgantolimod, Gilead's investigational TLR-8 agonist; VIR-2218, Vir's investigational small interfering ribonucleic acid; and a commercially-sourced, marketed PD-1 antagonist. People in the trial with HBV treatment experience may also receive Gilead's Vemlidy. The primary outcome of the study will be the proportion of patients achieving a functional cure, defined as an off-therapy loss of hepatitis B surface antigen and HBV DNA from the serum. Both companies retain full rights to their individual product candidates and will discuss the potential path forward for any future combination studies based on the outcome of the Phase 2 trial. Gilead
Vir Biotechnology
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