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SRNE

Sorrento Therapeutics

$10.27 /

+0.575 (+5.93%)

09:03
03/02/21
03/02
09:03
03/02/21
09:03

Sorrento Therapeutics receives FDA clearance to start STI-6643 trial

Sorrento Therapeutics announced that the FDA has cleared Sorrento's internally developed anti-CD47 monoclonal antibody, STI-6643, which was discovered from Sorrento's G-MAB library, for an initial clinical trial. The initial clinical trial will be a basket trial entitled "A Phase 1B, Open-Label, Dose-Escalation Study of the Safety and Efficacy of STI-6643, an Anti-CD47 Human Monoclonal Antibody, in Patients with Selected Relapsed or Refractory Malignancies." Cluster of differentiation 47 is a ubiquitously-expressed glycoprotein of the immunoglobulin superfamily that plays a critical role in self-recognition. Various solid and hematologic cancers exploit CD47 expression to evade immunological eradication, and its overexpression is clinically correlated with poor prognoses. One essential mechanism behind CD47-mediated immune evasion is that it can interact with signal regulatory protein-alpha expressed on myeloid cells, causing phosphorylation of the SIRPalpha cytoplasmic immunoreceptor tyrosine-based inhibition motifs and recruitment of Src homology 2 domain-containing tyrosine phosphatases to ultimately result in delivering an anti-phagocytic "don't eat me" signal. Given its essential role as a negative checkpoint for innate immunity and subsequent adaptive immunity, the CD47/SIRPalpha axis has been explored as a new target for cancer immunotherapy and its disruption has demonstrated great therapeutic promise. In preclinical evaluations, STI-6643 displayed decreased red blood cell binding and hemolysis, while maintaining potent anti-tumor activity in solid tumor disease models. Clinical trials with anti-CD47 mAbs have historically experienced limitations due to significant anemia, hemagglutination, and thrombocytopenia due to CD47 expression on normal red blood cells, ultimately requiring employment of complicated clinical dosing regimens. These issues have not been seen to date with STI-6643 in preclinical studies conducted head-to-head against synthesized versions of other CD47 mAbs. Additionally, STI-6643 showed minimal T, B or NK cell depletion as opposed to other synthesized mAb clones, which could potentially result in improved efficacy by preserving infiltrating anti-tumor immune cells. STI-6643 has the potential to be a "best-in-class" product if these preclinical benefits are able to be reproduced in human trials. Sorrento is also conducting preclinical studies to compare the safety and efficacy of lymphatic delivery of STI-6643 to established parenteral routes of administration using Sorrento's Sofusa(TM) technology. This study will be conducted at the Moffitt Cancer Center in Tampa, FL with Dr. David A. Sallman as the coordinating lead investigator. STI-6643 is the second anti-CD47 antibody that has been developed from the G-MAB library. The other anti-CD47 antibody discovered from the G-MAB library was previously cleared by the FDA, and is currently in Phase 1 human studies sponsored by ImmuneOncia Therapeutics, LLC, a joint venture company between Sorrento and Yuhan Corporation.

SRNE Sorrento Therapeutics
$10.27 /

+0.575 (+5.93%)

01/29/21 B. Riley
Sorrento Therapeutics initiated with a Buy at B. Riley Securities
01/21/21 Alliance Global Partners
Sorrento Therapeutics initiated with a Buy at Alliance Global Partners
07/31/20 H.C. Wainwright
Sorrento Therapeutics price target raised to $30 from $24 at H.C. Wainwright
07/20/20 Dawson James
Sorrento antibody cocktail effort could move quickly, says Dawson James

TODAY'S FREE FLY STORIES

Periodicals
Daimler sees 'intense' competition if Apple enters EV market, CEO tells CNBC » 09:45
04/15/21
04/15
09:45
04/15/21
09:45
DDAIF

Daimler AG

$90.20 /

-0.47 (-0.52%)

, GOOGL

Alphabet Class A

$2,260.86 /

+21.8 (+0.97%)

, GOOG

Alphabet

$2,272.61 /

+19.87 (+0.88%)

, AAPL

Apple

$133.84 /

+1.695 (+1.28%)

, BABA

Alibaba

$240.18 /

+0.94 (+0.39%)

Daimler (DDAIF) CEO Ola…

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DDAIF Daimler AG
$90.20 /

-0.47 (-0.52%)

GOOGL Alphabet Class A
$2,260.86 /

+21.8 (+0.97%)

GOOG Alphabet
$2,272.61 /

+19.87 (+0.88%)

AAPL Apple
$133.84 /

+1.695 (+1.28%)

BABA Alibaba
$240.18 /

+0.94 (+0.39%)

DDAIF Daimler AG
$90.20 /

-0.47 (-0.52%)

07:10 Today HSBC
Daimler AG price target raised to EUR 90 from EUR 75 at HSBC
04/12/21 Societe Generale
Daimler AG price target raised to EUR 100 from EUR 80 at Societe Generale
04/09/21 Barclays
Daimler AG price target raised to EUR 100 from EUR 96 at Barclays
03/30/21 Morgan Stanley
Daimler AG price target raised to EUR 74 from EUR 70 at Morgan Stanley
GOOGL Alphabet Class A
$2,260.86 /

+21.8 (+0.97%)

04/14/21 Wedbush
Wedbush bullish on Alphabet, assumes coverage with an Outperform
04/13/21 Wedbush
Alphabet assumed with Outperform, added to 'Best Ideas' at Wedbush
04/12/21 BMO Capital
Microsoft price target raised to $280 from $270 at BMO Capital
04/09/21 Argus
Alphabet price target raised to $2,500 from $2,400 at Argus
GOOG Alphabet
$2,272.61 /

+19.87 (+0.88%)

07:22 Today Cowen
Alphabet price target raised to $2600 from $2400 at Cowen
04/14/21 Wedbush
Wedbush bullish on Alphabet, assumes coverage with an Outperform
04/13/21 Wedbush
Alphabet assumed with Outperform, added to 'Best Ideas' at Wedbush
04/05/21 Evercore ISI
Alphabet assumed with an Outperform at Evercore ISI
AAPL Apple
$133.84 /

+1.695 (+1.28%)

04/14/21 Evercore ISI
Apple added to Tactical Outperform list at Evercore ISI
04/13/21 Wedbush
Facebook assumed with Neutral at Wedbush, cites privacy risk
04/12/21 Canaccord
Canaccord upgrades Tesla with over $1,000 target on 'Apple-esque' ecosystem
04/09/21 Citi
Citi tells investors to focus on Apple's capital deployment, iPhone gains
BABA Alibaba
$240.18 /

+0.94 (+0.39%)

04/13/21 Baird
Alibaba fines more benign than feared, says Baird
04/12/21 CLSA
Alibaba price target lowered to $320 from $351 at CLSA
04/12/21 Morgan Stanley
Alibaba named a Research Tactical Idea at Morgan Stanley
04/12/21 Raymond James
Alibaba price target lowered to $330 from $350 at Raymond James
DDAIF Daimler AG
$90.20 /

-0.47 (-0.52%)

GOOGL Alphabet Class A
$2,260.86 /

+21.8 (+0.97%)

GOOG Alphabet
$2,272.61 /

+19.87 (+0.88%)

AAPL Apple
$133.84 /

+1.695 (+1.28%)

BABA Alibaba
$240.18 /

+0.94 (+0.39%)

DDAIF Daimler AG
$90.20 /

-0.47 (-0.52%)

GOOGL Alphabet Class A
$2,260.86 /

+21.8 (+0.97%)

GOOG Alphabet
$2,272.61 /

+19.87 (+0.88%)

AAPL Apple
$133.84 /

+1.695 (+1.28%)

BABA Alibaba
$240.18 /

+0.94 (+0.39%)

GOOGL Alphabet Class A
$2,260.86 /

+21.8 (+0.97%)

GOOG Alphabet
$2,272.61 /

+19.87 (+0.88%)

AAPL Apple
$133.84 /

+1.695 (+1.28%)

BABA Alibaba
$240.18 /

+0.94 (+0.39%)

GOOGL Alphabet Class A
$2,260.86 /

+21.8 (+0.97%)

GOOG Alphabet
$2,272.61 /

+19.87 (+0.88%)

AAPL Apple
$133.84 /

+1.695 (+1.28%)

BABA Alibaba
$240.18 /

+0.94 (+0.39%)

Downgrade
Orchid Island Capital downgraded to Sell from Hold at JonesTrading » 09:43
04/15/21
04/15
09:43
04/15/21
09:43
ORC

Orchid Island Capital

$6.14 /

+ (+0.00%)

JonesTrading downgraded…

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ORC Orchid Island Capital
$6.14 /

+ (+0.00%)

10/30/20 Ladenburg
Orchid Island Capital upgraded to Buy from Neutral at Ladenburg
ORC Orchid Island Capital
$6.14 /

+ (+0.00%)

  • 03
    Mar
  • 21
    Jan
ORC Orchid Island Capital
$6.14 /

+ (+0.00%)

Initiation
Needham starts Teladoc at Buy citing 'durable growth opportunity' » 09:42
04/15/21
04/15
09:42
04/15/21
09:42
TDOC

Teladoc

$188.21 /

+ (+0.00%)

As previously reported,…

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TDOC Teladoc
$188.21 /

+ (+0.00%)

TDOC Teladoc
$188.21 /

+ (+0.00%)

06:25 Today Needham
Teladoc initiated with a Buy at Needham
04/08/21 Piper Sandler
Teladoc recent weakness a buying opportunity, says Piper Sandler
03/23/21 Piper Sandler
Piper remains buyer of telehealth companies despite Amazon competition
03/18/21 RBC Capital
Concerns over Amazon's impact on Teladoc overdone, says RBC Capital
TDOC Teladoc
$188.21 /

+ (+0.00%)

TDOC Teladoc
$188.21 /

+ (+0.00%)

TDOC Teladoc
$188.21 /

+ (+0.00%)

Options
Unusually active option classes on open April 15th » 09:40
04/15/21
04/15
09:40
04/15/21
09:40
HPE

HP Enterprise

$15.78 /

+ (+0.00%)

, GSK

GlaxoSmithKline

$36.12 /

+ (+0.00%)

, INO

Inovio

$8.85 /

+ (+0.00%)

, MLCO

Melco Resorts & Entertainment

$19.53 /

+ (+0.00%)

, BX

Blackstone

$78.01 /

+ (+0.00%)

, SPCE

Virgin Galactic

$26.65 /

+ (+0.00%)

, TSM

TSMC

$120.87 /

+ (+0.00%)

, AI

C3.ai

$68.41 /

-0.07 (-0.10%)

, V

Visa

$222.14 /

+ (+0.00%)

, DOCU

DocuSign

$225.45 /

+ (+0.00%)

Unusual total active…

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HPE HP Enterprise
$15.78 /

+ (+0.00%)

GSK GlaxoSmithKline
$36.12 /

+ (+0.00%)

INO Inovio
$8.85 /

+ (+0.00%)

MLCO Melco Resorts & Entertainment
$19.53 /

+ (+0.00%)

BX Blackstone
$78.01 /

+ (+0.00%)

SPCE Virgin Galactic
$26.65 /

+ (+0.00%)

TSM TSMC
$120.87 /

+ (+0.00%)

AI C3.ai
$68.41 /

-0.07 (-0.10%)

V Visa
$222.14 /

+ (+0.00%)

DOCU DocuSign
$225.45 /

+ (+0.00%)

HPE HP Enterprise
$15.78 /

+ (+0.00%)

04/08/21 Morgan Stanley
HP Enterprise price target raised to $17 from $15.50 at Morgan Stanley
03/26/21 JPMorgan
HP Enterprise price target raised to $18 from $17 at JPMorgan
03/10/21
Fly Intel: Top five analyst upgrades
03/10/21 Daiwa
HP Enterprise upgraded to Outperform from Neutral at Daiwa
GSK GlaxoSmithKline
$36.12 /

+ (+0.00%)

03/23/21
Fly Intel: Top five analyst downgrades
03/23/21 SVB Leerink
SVB Leerink moving to sidelines on Alexion, five others on industry concerns
03/23/21 SVB Leerink
GlaxoSmithKline downgraded to Market Perform from Outperform at SVB Leerink
03/08/21 JPMorgan
JPMorgan double downgrades AnaptysBio back to Underweight after trial miss
INO Inovio
$8.85 /

+ (+0.00%)

03/23/21
Fly Intel: Top five analyst initiations
03/23/21 BofA
Inovio initiated with a Neutral at BofA
03/02/21 Piper Sandler
Piper lowers Inovio target to $7 after 'decidedly negative' update
02/11/21 Oppenheimer
Opco starts DNA medicines 'disruptor' Inovio with buy, $35 price target
MLCO Melco Resorts & Entertainment
$19.53 /

+ (+0.00%)

02/25/21 CLSA
Melco Resorts & Entertainment upgraded to Outperform from Underperform at CLSA
01/07/21 Macquarie
Melco Resorts & Entertainment downgraded to Neutral from Outperform at Macquarie
11/17/20 JPMorgan
Melco Resorts & Entertainment price target raised to $25 from $23 at JPMorgan
11/05/20 Roth Capital
Roth Capital trims price target on 'go-to Macau name' Melco Resorts to $30
BX Blackstone
$78.01 /

+ (+0.00%)

04/12/21 Barclays
Blackstone price target raised to $85 from $75 at Barclays
04/09/21 Deutsche Bank
Blackstone price target raised to $66 from $61 at Deutsche Bank
03/19/21
Fly Intel: Top five analyst downgrades
03/18/21 Oppenheimer
Blackstone downgraded to Perform on valuation at Oppenheimer
SPCE Virgin Galactic
$26.65 /

+ (+0.00%)

04/12/21 Bernstein
Virgin Galactic initiated with a Market Perform at Bernstein
03/16/21 Truist
Truist starts 'uniquely positioned' Virgin Galactic at Buy with $50 price target
03/16/21 Truist
Virgin Galactic initiated with a Buy at Truist
03/03/21 BofA
Virgin Galactic price target raised to $50 from $35 at BofA
TSM TSMC
$120.87 /

+ (+0.00%)

04/12/21
Fly Intel: Top five analyst initiations
04/12/21 Atlantic Equities
TSMC initiated with a Neutral at Atlantic Equities
04/01/21 DA Davidson
Onto Innovation price target raised to $80 from $75 at DA Davidson
03/29/21 Citi
TSMC recent selloff brings 'enhanced buying opportunity,' says Citi
AI C3.ai
$68.41 /

-0.07 (-0.10%)

03/02/21 Canaccord
C3.ai price target lowered to $120 from $140 at Canaccord
01/04/21 KeyBanc
C3.ai initiated with a Sector Weight at KeyBanc
01/04/21 Wedbush
Wedbush bullish on C3.ai, initiates with an Outperform
01/04/21 Canaccord
C3.ai initiated with a Hold at Canaccord
V Visa
$222.14 /

+ (+0.00%)

03/19/21 JPMorgan
Visa has 'navigated heavy regulatory oversight' before, says JPMorgan
03/19/21 Wells Fargo
Visa selloff on WSJ story likely a buying opportunity, says Wells Fargo
03/19/21 Barclays
Visa, MasterCard facing new DOJ scrutiny on debt practices, says Barclays
03/16/21 Morgan Stanley
Visa price target raised to $253 from $233 at Morgan Stanley
DOCU DocuSign
$225.45 /

+ (+0.00%)

04/08/21 BofA
BofA reinstates DocuSign at Buy with $250 price target
04/08/21 BofA
DocuSign reinstated with a Buy at BofA
03/29/21 Daiwa
DocuSign initiated with a Buy at Daiwa
03/25/21 DA Davidson
DocuSign still confident in reaching $5B or more in revenue, says DA Davidson
HPE HP Enterprise
$15.78 /

+ (+0.00%)

GSK GlaxoSmithKline
$36.12 /

+ (+0.00%)

INO Inovio
$8.85 /

+ (+0.00%)

MLCO Melco Resorts & Entertainment
$19.53 /

+ (+0.00%)

BX Blackstone
$78.01 /

+ (+0.00%)

SPCE Virgin Galactic
$26.65 /

+ (+0.00%)

TSM TSMC
$120.87 /

+ (+0.00%)

AI C3.ai
$68.41 /

-0.07 (-0.10%)

V Visa
$222.14 /

+ (+0.00%)

DOCU DocuSign
$225.45 /

+ (+0.00%)

  • 21
    Jan
  • 09
    Dec
  • 13
    Oct
  • 06
    Aug
  • 03
    Jun
  • 20
    May
GSK GlaxoSmithKline
$36.12 /

+ (+0.00%)

BX Blackstone
$78.01 /

+ (+0.00%)

SPCE Virgin Galactic
$26.65 /

+ (+0.00%)

TSM TSMC
$120.87 /

+ (+0.00%)

V Visa
$222.14 /

+ (+0.00%)

DOCU DocuSign
$225.45 /

+ (+0.00%)

HPE HP Enterprise
$15.78 /

+ (+0.00%)

GSK GlaxoSmithKline
$36.12 /

+ (+0.00%)

INO Inovio
$8.85 /

+ (+0.00%)

MLCO Melco Resorts & Entertainment
$19.53 /

+ (+0.00%)

BX Blackstone
$78.01 /

+ (+0.00%)

SPCE Virgin Galactic
$26.65 /

+ (+0.00%)

TSM TSMC
$120.87 /

+ (+0.00%)

AI C3.ai
$68.41 /

-0.07 (-0.10%)

V Visa
$222.14 /

+ (+0.00%)

DOCU DocuSign
$225.45 /

+ (+0.00%)

HPE HP Enterprise
$15.78 /

+ (+0.00%)

INO Inovio
$8.85 /

+ (+0.00%)

MLCO Melco Resorts & Entertainment
$19.53 /

+ (+0.00%)

BX Blackstone
$78.01 /

+ (+0.00%)

SPCE Virgin Galactic
$26.65 /

+ (+0.00%)

TSM TSMC
$120.87 /

+ (+0.00%)

AI C3.ai
$68.41 /

-0.07 (-0.10%)

V Visa
$222.14 /

+ (+0.00%)

DOCU DocuSign
$225.45 /

+ (+0.00%)

General news
Treasury Action: it has been a curious reaction in the Treasury market » 09:40
04/15/21
04/15
09:40
04/15/21
09:40
$ECON

Economic Data

/

+

Treasury Action: it has…

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    Initiation
    Needham starts Amwell at Hold, sees limited near-term upside » 09:39
    04/15/21
    04/15
    09:39
    04/15/21
    09:39
    AMWL

    Amwell

    $17.20 /

    +0.24 (+1.42%)

    Needham analyst Ryan…

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    AMWL Amwell
    $17.20 /

    +0.24 (+1.42%)

    AMWL Amwell
    $17.20 /

    +0.24 (+1.42%)

    06:26 Today Needham
    Amwell initiated with a Hold at Needham
    03/25/21 Cowen
    Amwell price target lowered to $35 from $41 at Cowen
    03/25/21 Piper Sandler
    Amwell price target lowered to $30 from $45 at Piper Sandler
    03/23/21 Piper Sandler
    Piper remains buyer of telehealth companies despite Amazon competition
    AMWL Amwell
    $17.20 /

    +0.24 (+1.42%)

    • 15
      Jan
    • 17
      Sep
    AMWL Amwell
    $17.20 /

    +0.24 (+1.42%)

    AMWL Amwell
    $17.20 /

    +0.24 (+1.42%)

    Conference/Events
    Canaccord to hold a virtual conference » 09:39
    04/15/21
    04/15
    09:39
    04/15/21
    09:39
    ONCY

    Oncolytics

    $3.06 /

    -0.08 (-2.55%)

    , SESN

    Sesen Bio

    $2.35 /

    +0.015 (+0.64%)

    , OLMA

    Olema Oncology

    $35.84 /

    +3.56 (+11.03%)

    , SQZ

    SQZ Biotechnologies

    $13.06 /

    -0.12 (-0.91%)

    , APTO

    Aptose Biosciences

    $5.20 /

    +0.09 (+1.76%)

    , BCEL

    Atreca

    $12.42 /

    +0.83 (+7.16%)

    , BNTX

    BioNTech

    $132.52 /

    +3.11 (+2.40%)

    Horizons in Oncology…

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    ONCY Oncolytics
    $3.06 /

    -0.08 (-2.55%)

    SESN Sesen Bio
    $2.35 /

    +0.015 (+0.64%)

    OLMA Olema Oncology
    $35.84 /

    +3.56 (+11.03%)

    SQZ SQZ Biotechnologies
    $13.06 /

    -0.12 (-0.91%)

    APTO Aptose Biosciences
    $5.20 /

    +0.09 (+1.76%)

    BNTX BioNTech
    $132.52 /

    +3.11 (+2.40%)

    ONCY Oncolytics
    $3.06 /

    -0.08 (-2.55%)

    02/17/21 H.C. Wainwright
    Oncolytics initiated with a Buy at H.C. Wainwright
    05/11/20 RBC Capital
    Oncolytics price target lowered to C$6 from C$9 at RBC Capital
    SESN Sesen Bio
    $2.35 /

    +0.015 (+0.64%)

    02/17/21 Canaccord
    Sesen Bio price target raised to $7 from $5 at Canaccord
    02/16/21 Canaccord
    Sesen Bio price target raised to $7 from $5 at Canaccord
    02/16/21 Jefferies
    Jefferies doubles target on Sesen Bio to $6 on 'optimal scenario'
    01/25/21 Canaccord
    Sesen Bio a must-own small cap for 2021, says Canaccord
    OLMA Olema Oncology
    $35.84 /

    +3.56 (+11.03%)

    12/14/20 JPMorgan
    Olema Oncology initiated with an Overweight at JPMorgan
    12/14/20 Jefferies
    Olema Pharmaceuticals initiated with a Buy at Jefferies
    12/14/20 Canaccord
    Olema Pharmaceuticals initiated with a Buy at Canaccord
    12/14/20 Cowen
    Olema Pharmaceuticals initiated with an Outperform at Cowen
    SQZ SQZ Biotechnologies
    $13.06 /

    -0.12 (-0.91%)

    03/30/21 Brookline
    SQZ Biotechnologies initiated with a Buy at Brookline
    01/07/21 Evercore ISI
    SQZ Biotechnologies initiated with an Outperform at Evercore ISI
    11/24/20 Stifel
    SQZ Biotechnologies initiated with a Buy at Stifel
    11/24/20 BofA
    SQZ Biotechnologies initiated with a Buy at BofA
    APTO Aptose Biosciences
    $5.20 /

    +0.09 (+1.76%)

    02/22/21 JonesTrading
    Aptose Biosciences resumed with a Buy at JonesTrading
    10/19/20 Cantor Fitzgerald
    Aptose Biosciences initiated with an Overweight at Cantor Fitzgerald
    09/22/20 Alliance Global Partners
    Aptose Biosciences initiated with a Buy at Alliance Global Partners
    09/18/20 Piper Sandler
    Piper Sandler lays out next potential takeover targets in oncology
    BCEL Atreca
    $12.42 /

    +0.83 (+7.16%)

    02/08/21 Jefferies
    Atreca initiated with a Buy at Jefferies
    08/12/20 Stifel
    Volatility in Atreca shares creates 'interesting' opportunity, says Stifel
    07/08/20 Piper Sandler
    Xencor, Atreca deal offers synergies for XmAb design, says Piper Sandler
    07/01/20 Canaccord
    Atreca price target raised to $33 from $23 at Canaccord
    BNTX BioNTech
    $132.52 /

    +3.11 (+2.40%)

    02/23/21 B. Riley Securities
    B. Riley remains 'aggressive' buyer of Novavax after updated FDA guidance
    02/01/21 SVB Leerink
    Moderna price target raised to $80 from $69 at SVB Leerink
    01/29/21 Piper Sandler
    Moderna, Pfizer keep Covid vaccine competitive advantage, says Piper Sandler
    01/14/21 Morgan Stanley
    80%+ efficacy from J&J vaccine would be 'compelling,' says Morgan Stanley
    ONCY Oncolytics
    $3.06 /

    -0.08 (-2.55%)

    SESN Sesen Bio
    $2.35 /

    +0.015 (+0.64%)

    OLMA Olema Oncology
    $35.84 /

    +3.56 (+11.03%)

    APTO Aptose Biosciences
    $5.20 /

    +0.09 (+1.76%)

    BCEL Atreca
    $12.42 /

    +0.83 (+7.16%)

    • 12
      Feb
    • 19
      Nov
    • 30
      Oct
    • 23
      Jul
    • 16
      Jul
    • 16
      Jul
    BNTX BioNTech
    $132.52 /

    +3.11 (+2.40%)

    SESN Sesen Bio
    $2.35 /

    +0.015 (+0.64%)

    OLMA Olema Oncology
    $35.84 /

    +3.56 (+11.03%)

    SQZ SQZ Biotechnologies
    $13.06 /

    -0.12 (-0.91%)

    APTO Aptose Biosciences
    $5.20 /

    +0.09 (+1.76%)

    BNTX BioNTech
    $132.52 /

    +3.11 (+2.40%)

    OLMA Olema Oncology
    $35.84 /

    +3.56 (+11.03%)

    BNTX BioNTech
    $132.52 /

    +3.11 (+2.40%)

    Initiation
    Needham starts Accolade at Buy, sees engagement driving share gains » 09:38
    04/15/21
    04/15
    09:38
    04/15/21
    09:38
    ACCD

    Accolade

    $46.64 /

    -1.2 (-2.51%)

    As previously Needham…

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    ACCD Accolade
    $46.64 /

    -1.2 (-2.51%)

    ACCD Accolade
    $46.64 /

    -1.2 (-2.51%)

    06:24 Today Needham
    Accolade initiated with a Buy at Needham
    03/30/21 Piper Sandler
    Accolade recent volatility a buying opportunity, says Piper Sandler
    03/18/21 Canaccord
    Accolade price target raised to $62 from $59 at Canaccord
    03/11/21 Goldman Sachs
    Accolade reinstated with a Buy at Goldman Sachs
    ACCD Accolade
    $46.64 /

    -1.2 (-2.51%)

    • 22
      Oct
    • 02
      Jul
    ACCD Accolade
    $46.64 /

    -1.2 (-2.51%)

    ACCD Accolade
    $46.64 /

    -1.2 (-2.51%)

    ACCD Accolade
    $46.64 /

    -1.2 (-2.51%)

    Hot Stocks
    Bank of America expects card losses to be lower in Q2 » 09:36
    04/15/21
    04/15
    09:36
    04/15/21
    09:36
    BAC

    Bank of America

    $39.90 /

    +0.59 (+1.50%)

    Says "plenty of room…

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    BAC Bank of America
    $39.90 /

    +0.59 (+1.50%)

    BAC Bank of America
    $39.90 /

    +0.59 (+1.50%)

    04/09/21 Jefferies
    Bank of America price target raised to $41 from $33 at Jefferies
    04/07/21 Barclays
    Bank of America price target raised to $45 from $40 at Barclays
    04/05/21 Cowen
    Risk to mortgage servicers rises as CFPB proposes foreclosure policy, says Cowen
    04/01/21 Deutsche Bank
    Bank of America price target raised to $44 from $35 at Deutsche Bank
    BAC Bank of America
    $39.90 /

    +0.59 (+1.50%)

    BAC Bank of America
    $39.90 /

    +0.59 (+1.50%)

    BAC Bank of America
    $39.90 /

    +0.59 (+1.50%)

    BAC Bank of America
    $39.90 /

    +0.59 (+1.50%)

    Hot Stocks
    Senmiao Technology enters joint operation agreement with Hefei Cheyun » 09:32
    04/15/21
    04/15
    09:32
    04/15/21
    09:32
    AIHS

    Senmiao Technology

    $1.41 /

    -0.03 (-2.08%)

    Senmiao Technology…

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    AIHS Senmiao Technology
    $1.41 /

    -0.03 (-2.08%)

    Upgrade
    Tapestry upgraded to Positive from Mixed at OTR Global » 09:32
    04/15/21
    04/15
    09:32
    04/15/21
    09:32
    TPR

    Tapestry

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    OTR Global analyst…

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    TPR Tapestry
    /

    +

    TPR Tapestry
    /

    +

    04/07/21 Piper Sandler
    Tapestry price target raised to $54 from $45 at Piper Sandler
    03/05/21 BMO Capital
    Tapestry price target raised to $45 from $36 at BMO Capital
    02/22/21 Credit Suisse
    Tapestry upgraded to Outperform with $50 target at Credit Suisse
    02/22/21 Credit Suisse
    Tapestry upgraded to Outperform from Neutral at Credit Suisse
    TPR Tapestry
    /

    +

    TPR Tapestry
    /

    +

    TPR Tapestry
    /

    +

    Upgrade
    Capri Holdings upgraded to Positive from Mixed at OTR Global » 09:32
    04/15/21
    04/15
    09:32
    04/15/21
    09:32
    CPRI

    Capri Holdings

    $52.49 /

    -0.31 (-0.59%)

    OTR Global analyst…

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    CPRI Capri Holdings
    $52.49 /

    -0.31 (-0.59%)

    CPRI Capri Holdings
    $52.49 /

    -0.31 (-0.59%)

    03/23/21 Wells Fargo
    Capri Holdings price target raised to $65 from $60 at Wells Fargo
    03/15/21 Piper Sandler
    Capri Holdings price target raised to $63 from $58 at Piper Sandler
    02/04/21
    Capri Holdings price target raised to $52 from $50 at Barclays
    01/29/21 Baird
    Capri upgraded to Outperform on multi-year recovery at Baird
    CPRI Capri Holdings
    $52.49 /

    -0.31 (-0.59%)

    CPRI Capri Holdings
    $52.49 /

    -0.31 (-0.59%)

    CPRI Capri Holdings
    $52.49 /

    -0.31 (-0.59%)

    CPRI Capri Holdings
    $52.49 /

    -0.31 (-0.59%)

    General news
    March manufacturing output up 2.7%, consensus 3.6%  09:30
    04/15/21
    04/15
    09:30
    04/15/21
    09:30
    $ECON

    Economic Data

    /

    +

     
    ShowHide Related Items >><<
      General news
      March capacity utilization rate up 74.4%, consensus 75.7%  09:30
      04/15/21
      04/15
      09:30
      04/15/21
      09:30
      $ECON

      Economic Data

      /

      +

       
      ShowHide Related Items >><<
        General news
        March industrial production up 1.4%, consensus 2.8%  09:30
        04/15/21
        04/15
        09:30
        04/15/21
        09:30
        $ECON

        Economic Data

        /

        +

         
        ShowHide Related Items >><<
          Hot Stocks
          MasterCard appoints Tim Murphy as chief administrative officer » 09:30
          04/15/21
          04/15
          09:30
          04/15/21
          09:30
          MA

          MasterCard

          $378.37 /

          +0.295 (+0.08%)

          Mastercard announced the…

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          MA MasterCard
          $378.37 /

          +0.295 (+0.08%)

          MA MasterCard
          $378.37 /

          +0.295 (+0.08%)

          04/13/21 Morgan Stanley
          Synchrony loss of Gap card deal 'likely a positive,' says Morgan Stanley
          03/19/21 Wells Fargo
          Visa selloff on WSJ story likely a buying opportunity, says Wells Fargo
          03/19/21 Barclays
          Visa, MasterCard facing new DOJ scrutiny on debt practices, says Barclays
          03/16/21 Morgan Stanley
          MasterCard price target raised to $412 from $377 at Morgan Stanley
          MA MasterCard
          $378.37 /

          +0.295 (+0.08%)

          MA MasterCard
          $378.37 /

          +0.295 (+0.08%)

          MA MasterCard
          $378.37 /

          +0.295 (+0.08%)

          MA MasterCard
          $378.37 /

          +0.295 (+0.08%)

          Periodicals
          Syneos could be CRO 'target still standing when music stops,' Dealreporter says » 09:29
          04/15/21
          04/15
          09:29
          04/15/21
          09:29
          SYNH

          Syneos Health

          $79.53 /

          +0.68 (+0.86%)

          , TMO

          Thermo Fisher

          $477.68 /

          -7.13 (-1.47%)

          , PPD

          PPD

          $42.65 /

          +4.3 (+11.21%)

          , ICLR

          Icon

          $196.37 /

          -1.44 (-0.73%)

          After Thermo Fisher (TMO)…

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          SYNH Syneos Health
          $79.53 /

          +0.68 (+0.86%)

          TMO Thermo Fisher
          $477.68 /

          -7.13 (-1.47%)

          PPD PPD
          $42.65 /

          +4.3 (+11.21%)

          ICLR Icon
          $196.37 /

          -1.44 (-0.73%)

          SYNH Syneos Health
          $79.53 /

          +0.68 (+0.86%)

          03/02/21 Barclays
          Syneos Health initiated with an Equal Weight at Barclays
          03/02/21 Barclays
          Syneos Health initiated with an Equal Weight at Barclays
          02/22/21 Mizuho
          Syneos Health price target raised to $87 from $72 at Mizuho
          02/19/21 Citi
          Syneos Health price target raised to $85 from $80 at Citi
          TMO Thermo Fisher
          $477.68 /

          -7.13 (-1.47%)

          06:53 Today Citi
          Thermo Fisher deal for PPD would make sense, says Citi
          03/29/21 UBS
          Thermo Fisher price target lowered to $560 from $588 at UBS
          03/18/21 KeyBanc
          Thermo Fisher upgraded to Overweight at KeyBanc after Sartorius guidance
          03/18/21 KeyBanc
          Thermo Fisher upgraded to Overweight from Sector Weight at KeyBanc
          PPD PPD
          $42.65 /

          +4.3 (+11.21%)

          09:17 Today Baird
          PPD downgraded to Neutral from Outperform at Baird
          06:53 Today Citi
          Thermo Fisher deal for PPD would make sense, says Citi
          03/02/21 Barclays
          PPD initiated with an Overweight at Barclays
          03/02/21 Barclays
          PPD initiated with an Overweight at Barclays
          ICLR Icon
          $196.37 /

          -1.44 (-0.73%)

          04/13/21 BofA
          Icon resumed with a Neutral at BofA
          04/01/21 Wells Fargo
          Icon upgraded to Overweight from Equal Weight at Wells Fargo
          04/01/21 Wells Fargo
          Icon upgraded to Overweight from Equal Weight at Wells Fargo
          03/19/21 Mizuho
          PRA Health price target raised to $155 from $110 at Mizuho
          SYNH Syneos Health
          $79.53 /

          +0.68 (+0.86%)

          TMO Thermo Fisher
          $477.68 /

          -7.13 (-1.47%)

          PPD PPD
          $42.65 /

          +4.3 (+11.21%)

          ICLR Icon
          $196.37 /

          -1.44 (-0.73%)

          • 01
            Mar
          • 02
            Dec
          • 17
            Sep
          • 16
            Sep
          TMO Thermo Fisher
          $477.68 /

          -7.13 (-1.47%)

          PPD PPD
          $42.65 /

          +4.3 (+11.21%)

          TMO Thermo Fisher
          $477.68 /

          -7.13 (-1.47%)

          PPD PPD
          $42.65 /

          +4.3 (+11.21%)

          ICLR Icon
          $196.37 /

          -1.44 (-0.73%)

          Hot Stocks
          Clover Health appoints Demetrios Kouzakas to board of directors » 09:29
          04/15/21
          04/15
          09:29
          04/15/21
          09:29
          CLOV

          Clover Health

          $7.43 /

          -0.38 (-4.87%)

          Clover Health Investments…

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          CLOV Clover Health
          $7.43 /

          -0.38 (-4.87%)

          CLOV Clover Health
          $7.43 /

          -0.38 (-4.87%)

          03/09/21 Credit Suisse
          Clover Health initiated with a Neutral at Credit Suisse
          03/03/21 Citi
          Clover Health price target lowered to $13 from $19 at Citi
          02/02/21
          Fly Intel: Top five analyst initiations
          02/02/21 Citi
          Clover Health initiated with a Buy at Citi
          CLOV Clover Health
          $7.43 /

          -0.38 (-4.87%)

          CLOV Clover Health
          $7.43 /

          -0.38 (-4.87%)

          CLOV Clover Health
          $7.43 /

          -0.38 (-4.87%)

          Downgrade
          New Residential downgraded to Hold from Buy at JonesTrading » 09:29
          04/15/21
          04/15
          09:29
          04/15/21
          09:29
          NRZ

          New Residential

          $10.38 /

          -0.545 (-4.99%)

          JonesTrading analyst…

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          NRZ New Residential
          $10.38 /

          -0.545 (-4.99%)

          NRZ New Residential
          $10.38 /

          -0.545 (-4.99%)

          03/26/21 Credit Suisse
          Credit Suisse lowers estimates on mortgage originators
          03/25/21 RBC Capital
          New Residential initiated with an Outperform at RBC Capital
          02/16/21 Piper Sandler
          New Residential price target raised to $11 from $10 at Piper Sandler
          12/18/20 Keefe Bruyette
          New Residential upgraded to Outperform from Market Perform at Keefe Bruyette
          NRZ New Residential
          $10.38 /

          -0.545 (-4.99%)

          • 15
            Apr
          NRZ New Residential
          $10.38 /

          -0.545 (-4.99%)

          NRZ New Residential
          $10.38 /

          -0.545 (-4.99%)

          Hot Stocks
          Legion files proxy statement and issues letter to OneSpan shareholders » 09:29
          04/15/21
          04/15
          09:29
          04/15/21
          09:29
          OSPN

          OneSpan

          $26.54 /

          -0.34 (-1.26%)

          Legion Partners Asset…

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          OSPN OneSpan
          $26.54 /

          -0.34 (-1.26%)

          08:57 Today Sidoti
          OneSpan upgraded to Buy from Neutral at Sidoti
          03/31/21 DA Davidson
          OneSpan initiated with a Buy at DA Davidson as revenue growth accelerates
          03/30/21 DA Davidson
          OneSpan initiated with a Buy at DA Davidson
          02/19/21 Sidoti
          OneSpan downgraded to Neutral from Buy at Sidoti
          OSPN OneSpan
          $26.54 /

          -0.34 (-1.26%)

          OSPN OneSpan
          $26.54 /

          -0.34 (-1.26%)

          Hot Stocks
          Hop-on begins integration testing, certification of DigitalAge features » 09:28
          04/15/21
          04/15
          09:28
          04/15/21
          09:28
          HPNN

          Hop-on, Inc.

          /

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          Hop-on has begun…

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          Hot Stocks
          CleanSpark purchases 22,680 additional bitcoin miners » 09:28
          04/15/21
          04/15
          09:28
          04/15/21
          09:28
          CLSK

          CleanSpark

          $21.28 /

          -0.47 (-2.16%)

          CleanSpark has secured…

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          CLSK CleanSpark
          $21.28 /

          -0.47 (-2.16%)

          CLSK CleanSpark
          $21.28 /

          -0.47 (-2.16%)

          03/10/21 BTIG
          CleanSpark initiated with a Buy at BTIG
          03/10/21 BTIG
          CleanSpark initiated with a Buy at BTIG
          02/16/21 H.C. Wainwright
          CleanSpark price target raised to $50 from $24 at H.C. Wainwright
          12/11/20 H.C. Wainwright
          CleanSpark price target raised to $24 from $18 at H.C. Wainwright
          CLSK CleanSpark
          $21.28 /

          -0.47 (-2.16%)

          • 16
            Mar
          • 07
            Oct
          CLSK CleanSpark
          $21.28 /

          -0.47 (-2.16%)

          CLSK CleanSpark
          $21.28 /

          -0.47 (-2.16%)

          CLSK CleanSpark
          $21.28 /

          -0.47 (-2.16%)

          Hot Stocks
          CytoDyn enters supply, distribution agreement with Chiral Pharma » 09:27
          04/15/21
          04/15
          09:27
          04/15/21
          09:27
          CYDY

          CytoDyn

          $2.85 /

          -0.14 (-4.68%)

          CytoDyn announced it has…

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          CYDY CytoDyn
          $2.85 /

          -0.14 (-4.68%)

          CYDY CytoDyn
          $2.85 /

          -0.14 (-4.68%)

          04/06/21
          CytoDyn to host conference call
          04/06/21
          CytoDyn to host conference call
          07/06/20 H.C. Wainwright
          CytoDyn downgraded to Neutral from Buy at H.C. Wainwright
          04/28/20 H.C. Wainwright
          CytoDyn price target raised to $4 from $3 at H.C. Wainwright
          General news
          FX Action: USD-CAD » 09:25
          04/15/21
          04/15
          09:25
          04/15/21
          09:25
          $ECON

          Economic Data

          /

          +

          FX Action: USD-CAD hit…

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            General news
            U.S. industrial production rebounded 1.4% in March » 09:25
            04/15/21
            04/15
            09:25
            04/15/21
            09:25
            $ECON

            Economic Data

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            U.S. industrial…

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